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Spider-venom peptides: structure, pharmacology, and potential for control of insect pests.
Annu Rev Entomol. 2013; 58:475-96.AR

Abstract

Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have been tuned over millions of years to target a wide range of receptors and ion channels in the insect nervous system. These peptides can act individually, or as part of larger toxin cabals, to rapidly immobilize envenomated prey owing to their debilitating effects on nervous system function. Most of these peptides contain a unique arrangement of disulfide bonds that provides them with extreme resistance to proteases. As a result, these peptides are highly stable in the insect gut and hemolymph and many of them are orally active. Thus, spider-venom peptides can be used as stand-alone bioinsecticides, or transgenes encoding these peptides can be used to engineer insect-resistant crops or enhanced entomopathogens. We critically review the potential of spider-venom peptides to control insect pests and highlight their advantages and disadvantages compared with conventional chemical insecticides.

Authors+Show Affiliations

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia. glenn.king@imb.uq.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23020618

Citation

King, Glenn F., and Margaret C. Hardy. "Spider-venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests." Annual Review of Entomology, vol. 58, 2013, pp. 475-96.
King GF, Hardy MC. Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. Annu Rev Entomol. 2013;58:475-96.
King, G. F., & Hardy, M. C. (2013). Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. Annual Review of Entomology, 58, 475-96. https://doi.org/10.1146/annurev-ento-120811-153650
King GF, Hardy MC. Spider-venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests. Annu Rev Entomol. 2013;58:475-96. PubMed PMID: 23020618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. AU - King,Glenn F, AU - Hardy,Margaret C, Y1 - 2012/09/27/ PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/6/26/medline SP - 475 EP - 96 JF - Annual review of entomology JO - Annu. Rev. Entomol. VL - 58 N2 - Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have been tuned over millions of years to target a wide range of receptors and ion channels in the insect nervous system. These peptides can act individually, or as part of larger toxin cabals, to rapidly immobilize envenomated prey owing to their debilitating effects on nervous system function. Most of these peptides contain a unique arrangement of disulfide bonds that provides them with extreme resistance to proteases. As a result, these peptides are highly stable in the insect gut and hemolymph and many of them are orally active. Thus, spider-venom peptides can be used as stand-alone bioinsecticides, or transgenes encoding these peptides can be used to engineer insect-resistant crops or enhanced entomopathogens. We critically review the potential of spider-venom peptides to control insect pests and highlight their advantages and disadvantages compared with conventional chemical insecticides. SN - 1545-4487 UR - https://www.unboundmedicine.com/medline/citation/23020618/Spider_venom_peptides:_structure_pharmacology_and_potential_for_control_of_insect_pests_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-ento-120811-153650?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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