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Effect of vitamin D deficiency and replacement on endothelial functions in Behçet's disease.
Clin Exp Rheumatol. 2012 May-Jun; 30(3 Suppl 72):S57-61.CE

Abstract

OBJECTIVES

Endothelial dysfunction is previously demonstrated in Behçet's disease (BD) and vitamin D is implicated to affect endothelial functions. We aimed to evaluate the status of serum 25(OH)Vit D3 levels and its association with disease activity, endothelial function and carotis intima media thickness (CIMT) in patients with BD.

METHODS

Thirty-six BD (F/M: 22/14, mean age: 39.6 years) patients and 51 healthy controls (F/M: 28/23, mean age: 34.5 years) were studied. Rheumatoid arthritis (RA) (n=33) patients (F/M: 26/7, mean age: 50.82 years) were also enrolled, as a disease control group. Endothelial function was evaluated by brachial artery flow mediated dilatation (FMD) and CIMT with B-Mode ultrasound. The vitamin D-deficient BD patients received 1000 IU Vitamin D3 daily for 3 months.

RESULTS

Less than 50 nmol/L levels of 25(OH) Vit D3 were present in 61.1% (n=22) of BD and 35.3% (n=18) of HC (serum 25(OH)Vit D3 levels: BD: 44.5 (9-112) vs HC: 56 (14-125) nmol/lt, p=0.01). CIMT and FMD were also significantly different between BD and HC [0.56 (0.35-9.26) vs. 0.39 (0-0.52) and 5.20 (0.56-30.58) vs. 9.04 (-6.9-34.17), p=0.001 and p=0.02, respectively]. However, no correlation was observed between 25(OH)VitD3 levels and CIMT or FMD (r=0.6, p=0.7 and r=0.03, p=0.8, respectively) at baseline. CIMT measurements improved after replacement therapy (0.56 vs. 0.49, p=0.02), FMD measurements also improved, but not reaching statistical significance (5.2 vs. 8.28, p=0.06).

CONCLUSIONS

A high presence of vitamin D deficiency was observed in BD patients from Turkey and replacement of vitamin D had favourable effects on endothelial function.

Authors+Show Affiliations

Department of Rheumatology, Marmara University, Pendik Training and Research Hospital, Istanbul, Turkey. meryemkrk@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23020973

Citation

Can, M, et al. "Effect of Vitamin D Deficiency and Replacement On Endothelial Functions in Behçet's Disease." Clinical and Experimental Rheumatology, vol. 30, no. 3 Suppl 72, 2012, pp. S57-61.
Can M, Gunes M, Haliloglu OA, et al. Effect of vitamin D deficiency and replacement on endothelial functions in Behçet's disease. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S57-61.
Can, M., Gunes, M., Haliloglu, O. A., Haklar, G., Inanç, N., Yavuz, D. G., & Direskeneli, H. (2012). Effect of vitamin D deficiency and replacement on endothelial functions in Behçet's disease. Clinical and Experimental Rheumatology, 30(3 Suppl 72), S57-61.
Can M, et al. Effect of Vitamin D Deficiency and Replacement On Endothelial Functions in Behçet's Disease. Clin Exp Rheumatol. 2012 May-Jun;30(3 Suppl 72):S57-61. PubMed PMID: 23020973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin D deficiency and replacement on endothelial functions in Behçet's disease. AU - Can,M, AU - Gunes,M, AU - Haliloglu,O A, AU - Haklar,G, AU - Inanç,N, AU - Yavuz,D G, AU - Direskeneli,H, Y1 - 2012/09/27/ PY - 2012/03/12/received PY - 2012/08/29/accepted PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/2/6/medline SP - S57 EP - 61 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 30 IS - 3 Suppl 72 N2 - OBJECTIVES: Endothelial dysfunction is previously demonstrated in Behçet's disease (BD) and vitamin D is implicated to affect endothelial functions. We aimed to evaluate the status of serum 25(OH)Vit D3 levels and its association with disease activity, endothelial function and carotis intima media thickness (CIMT) in patients with BD. METHODS: Thirty-six BD (F/M: 22/14, mean age: 39.6 years) patients and 51 healthy controls (F/M: 28/23, mean age: 34.5 years) were studied. Rheumatoid arthritis (RA) (n=33) patients (F/M: 26/7, mean age: 50.82 years) were also enrolled, as a disease control group. Endothelial function was evaluated by brachial artery flow mediated dilatation (FMD) and CIMT with B-Mode ultrasound. The vitamin D-deficient BD patients received 1000 IU Vitamin D3 daily for 3 months. RESULTS: Less than 50 nmol/L levels of 25(OH) Vit D3 were present in 61.1% (n=22) of BD and 35.3% (n=18) of HC (serum 25(OH)Vit D3 levels: BD: 44.5 (9-112) vs HC: 56 (14-125) nmol/lt, p=0.01). CIMT and FMD were also significantly different between BD and HC [0.56 (0.35-9.26) vs. 0.39 (0-0.52) and 5.20 (0.56-30.58) vs. 9.04 (-6.9-34.17), p=0.001 and p=0.02, respectively]. However, no correlation was observed between 25(OH)VitD3 levels and CIMT or FMD (r=0.6, p=0.7 and r=0.03, p=0.8, respectively) at baseline. CIMT measurements improved after replacement therapy (0.56 vs. 0.49, p=0.02), FMD measurements also improved, but not reaching statistical significance (5.2 vs. 8.28, p=0.06). CONCLUSIONS: A high presence of vitamin D deficiency was observed in BD patients from Turkey and replacement of vitamin D had favourable effects on endothelial function. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/23020973/Effect_of_vitamin_D_deficiency_and_replacement_on_endothelial_functions_in_Behçet's_disease_ DB - PRIME DP - Unbound Medicine ER -