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Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study.

Abstract

BACKGROUND

Data on celiac disease (CD) and the risk of lung cancer are contradictory, with several studies suggesting a protective effect of CD. We investigated the future risk of lung cancer in individuals with biopsy-verified CD.

METHODS

In this cohort study we used biopsy reports from 28 Swedish pathology departments to identify adults with CD who had been diagnosed between 1969 and 2008 (Marsh 3: villous atrophy). Each patient with CD (n=18,365) was matched with up to five reference individuals (n=90,962) from the general population matched for age, sex, calendar year and county. Lung cancer events were identified through the Swedish Cancer Register. Using Cox regression, we then calculated hazard ratios (HRs) for lung cancer.

RESULTS

During follow-up there were 109 cases of lung cancer in patients with CD, and 470 among reference individuals. This corresponded to a HR of 1.07 (95% CI=0.87-1.32). The absolute risk of future lung cancer in patients with CD was 57/100,000 person-years (excess risk=4/100,000 person-years). In the first year after CD diagnosis, the HR for lung cancer was 2.01 (95% CI=1.08-3.76), decreasing to a HR of 1.00 beyond the first year of follow-up (95% CI=0.80-1.25). There was no difference in men or women with CD, and age at CD onset did not influence the risk of lung cancer.

CONCLUSION

In a Swedish setting, patients with CD were at a similar risk of lung cancer to reference individuals from the general population.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Örebro University Hospital, 701 85 Örebro, Sweden. jonasludvigsson@yahoo.com

    , ,

    Source

    Lung cancer (Amsterdam, Netherlands) 78:3 2012 Dec pg 179-84

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Celiac Disease
    Cohort Studies
    Female
    Health Surveys
    Humans
    Incidence
    Lung Neoplasms
    Male
    Middle Aged
    Proportional Hazards Models
    Risk
    Sweden
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23021207

    Citation

    Ludvigsson, Jonas F., et al. "Neutral Risk of Lung Cancer in Adults With Celiac Disease--nationwide Cohort Study." Lung Cancer (Amsterdam, Netherlands), vol. 78, no. 3, 2012, pp. 179-84.
    Ludvigsson JF, West J, Hubbard R, et al. Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study. Lung Cancer. 2012;78(3):179-84.
    Ludvigsson, J. F., West, J., Hubbard, R., & Card, T. (2012). Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study. Lung Cancer (Amsterdam, Netherlands), 78(3), pp. 179-84. doi:10.1016/j.lungcan.2012.09.003.
    Ludvigsson JF, et al. Neutral Risk of Lung Cancer in Adults With Celiac Disease--nationwide Cohort Study. Lung Cancer. 2012;78(3):179-84. PubMed PMID: 23021207.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study. AU - Ludvigsson,Jonas F, AU - West,Joe, AU - Hubbard,Richard, AU - Card,Tim, Y1 - 2012/09/27/ PY - 2012/03/21/received PY - 2012/08/28/revised PY - 2012/09/03/accepted PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/4/12/medline SP - 179 EP - 84 JF - Lung cancer (Amsterdam, Netherlands) JO - Lung Cancer VL - 78 IS - 3 N2 - BACKGROUND: Data on celiac disease (CD) and the risk of lung cancer are contradictory, with several studies suggesting a protective effect of CD. We investigated the future risk of lung cancer in individuals with biopsy-verified CD. METHODS: In this cohort study we used biopsy reports from 28 Swedish pathology departments to identify adults with CD who had been diagnosed between 1969 and 2008 (Marsh 3: villous atrophy). Each patient with CD (n=18,365) was matched with up to five reference individuals (n=90,962) from the general population matched for age, sex, calendar year and county. Lung cancer events were identified through the Swedish Cancer Register. Using Cox regression, we then calculated hazard ratios (HRs) for lung cancer. RESULTS: During follow-up there were 109 cases of lung cancer in patients with CD, and 470 among reference individuals. This corresponded to a HR of 1.07 (95% CI=0.87-1.32). The absolute risk of future lung cancer in patients with CD was 57/100,000 person-years (excess risk=4/100,000 person-years). In the first year after CD diagnosis, the HR for lung cancer was 2.01 (95% CI=1.08-3.76), decreasing to a HR of 1.00 beyond the first year of follow-up (95% CI=0.80-1.25). There was no difference in men or women with CD, and age at CD onset did not influence the risk of lung cancer. CONCLUSION: In a Swedish setting, patients with CD were at a similar risk of lung cancer to reference individuals from the general population. SN - 1872-8332 UR - https://www.unboundmedicine.com/medline/citation/23021207/Neutral_risk_of_lung_cancer_in_adults_with_celiac_disease__nationwide_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-5002(12)00527-2 DB - PRIME DP - Unbound Medicine ER -