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Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study.
Lung Cancer 2012; 78(3):179-84LC

Abstract

BACKGROUND

Data on celiac disease (CD) and the risk of lung cancer are contradictory, with several studies suggesting a protective effect of CD. We investigated the future risk of lung cancer in individuals with biopsy-verified CD.

METHODS

In this cohort study we used biopsy reports from 28 Swedish pathology departments to identify adults with CD who had been diagnosed between 1969 and 2008 (Marsh 3: villous atrophy). Each patient with CD (n=18,365) was matched with up to five reference individuals (n=90,962) from the general population matched for age, sex, calendar year and county. Lung cancer events were identified through the Swedish Cancer Register. Using Cox regression, we then calculated hazard ratios (HRs) for lung cancer.

RESULTS

During follow-up there were 109 cases of lung cancer in patients with CD, and 470 among reference individuals. This corresponded to a HR of 1.07 (95% CI=0.87-1.32). The absolute risk of future lung cancer in patients with CD was 57/100,000 person-years (excess risk=4/100,000 person-years). In the first year after CD diagnosis, the HR for lung cancer was 2.01 (95% CI=1.08-3.76), decreasing to a HR of 1.00 beyond the first year of follow-up (95% CI=0.80-1.25). There was no difference in men or women with CD, and age at CD onset did not influence the risk of lung cancer.

CONCLUSION

In a Swedish setting, patients with CD were at a similar risk of lung cancer to reference individuals from the general population.

Authors+Show Affiliations

Department of Pediatrics, Örebro University Hospital, 701 85 Örebro, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23021207

Citation

Ludvigsson, Jonas F., et al. "Neutral Risk of Lung Cancer in Adults With Celiac Disease--nationwide Cohort Study." Lung Cancer (Amsterdam, Netherlands), vol. 78, no. 3, 2012, pp. 179-84.
Ludvigsson JF, West J, Hubbard R, et al. Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study. Lung Cancer. 2012;78(3):179-84.
Ludvigsson, J. F., West, J., Hubbard, R., & Card, T. (2012). Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study. Lung Cancer (Amsterdam, Netherlands), 78(3), pp. 179-84. doi:10.1016/j.lungcan.2012.09.003.
Ludvigsson JF, et al. Neutral Risk of Lung Cancer in Adults With Celiac Disease--nationwide Cohort Study. Lung Cancer. 2012;78(3):179-84. PubMed PMID: 23021207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutral risk of lung cancer in adults with celiac disease--nationwide cohort study. AU - Ludvigsson,Jonas F, AU - West,Joe, AU - Hubbard,Richard, AU - Card,Tim, Y1 - 2012/09/27/ PY - 2012/03/21/received PY - 2012/08/28/revised PY - 2012/09/03/accepted PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/4/12/medline SP - 179 EP - 84 JF - Lung cancer (Amsterdam, Netherlands) JO - Lung Cancer VL - 78 IS - 3 N2 - BACKGROUND: Data on celiac disease (CD) and the risk of lung cancer are contradictory, with several studies suggesting a protective effect of CD. We investigated the future risk of lung cancer in individuals with biopsy-verified CD. METHODS: In this cohort study we used biopsy reports from 28 Swedish pathology departments to identify adults with CD who had been diagnosed between 1969 and 2008 (Marsh 3: villous atrophy). Each patient with CD (n=18,365) was matched with up to five reference individuals (n=90,962) from the general population matched for age, sex, calendar year and county. Lung cancer events were identified through the Swedish Cancer Register. Using Cox regression, we then calculated hazard ratios (HRs) for lung cancer. RESULTS: During follow-up there were 109 cases of lung cancer in patients with CD, and 470 among reference individuals. This corresponded to a HR of 1.07 (95% CI=0.87-1.32). The absolute risk of future lung cancer in patients with CD was 57/100,000 person-years (excess risk=4/100,000 person-years). In the first year after CD diagnosis, the HR for lung cancer was 2.01 (95% CI=1.08-3.76), decreasing to a HR of 1.00 beyond the first year of follow-up (95% CI=0.80-1.25). There was no difference in men or women with CD, and age at CD onset did not influence the risk of lung cancer. CONCLUSION: In a Swedish setting, patients with CD were at a similar risk of lung cancer to reference individuals from the general population. SN - 1872-8332 UR - https://www.unboundmedicine.com/medline/citation/23021207/Neutral_risk_of_lung_cancer_in_adults_with_celiac_disease__nationwide_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-5002(12)00527-2 DB - PRIME DP - Unbound Medicine ER -