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Homocysteine and cysteine levels in prepubertal children: association with waist circumference and lipid profile.
Nutrition. 2013 Jan; 29(1):166-71.N

Abstract

OBJECTIVE

To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.

METHODS

Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. The weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.

RESULTS

The median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%), respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. The median homocysteine and total cysteine plasma levels were 5.6 μmol/L (0.1-11.7) and 365.7 μmol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 μmol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 μmol/L).

CONCLUSION

The association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk.

Authors+Show Affiliations

Departamento de Pediatria, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23022121

Citation

da Silva, Narjara Pereira, et al. "Homocysteine and Cysteine Levels in Prepubertal Children: Association With Waist Circumference and Lipid Profile." Nutrition (Burbank, Los Angeles County, Calif.), vol. 29, no. 1, 2013, pp. 166-71.
da Silva NP, de Souza FI, Pendezza AI, et al. Homocysteine and cysteine levels in prepubertal children: association with waist circumference and lipid profile. Nutrition. 2013;29(1):166-71.
da Silva, N. P., de Souza, F. I., Pendezza, A. I., Fonseca, F. L., Hix, S., Oliveira, A. C., Sarni, R. O., & D'Almeida, V. (2013). Homocysteine and cysteine levels in prepubertal children: association with waist circumference and lipid profile. Nutrition (Burbank, Los Angeles County, Calif.), 29(1), 166-71. https://doi.org/10.1016/j.nut.2012.05.015
da Silva NP, et al. Homocysteine and Cysteine Levels in Prepubertal Children: Association With Waist Circumference and Lipid Profile. Nutrition. 2013;29(1):166-71. PubMed PMID: 23022121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine and cysteine levels in prepubertal children: association with waist circumference and lipid profile. AU - da Silva,Narjara Pereira, AU - de Souza,Fabíola Isabel Suano, AU - Pendezza,Aline Ifanger, AU - Fonseca,Fernando Luiz Affonso, AU - Hix,Sonia, AU - Oliveira,Allan Chiaratti, AU - Sarni,Roseli Oselka Saccardo, AU - D'Almeida,Vânia, Y1 - 2012/09/28/ PY - 2012/01/23/received PY - 2012/05/20/revised PY - 2012/05/30/accepted PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/5/15/medline SP - 166 EP - 71 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 29 IS - 1 N2 - OBJECTIVE: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations. METHODS: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. The weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%. RESULTS: The median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%), respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. The median homocysteine and total cysteine plasma levels were 5.6 μmol/L (0.1-11.7) and 365.7 μmol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 μmol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 μmol/L). CONCLUSION: The association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/23022121/Homocysteine_and_cysteine_levels_in_prepubertal_children:_association_with_waist_circumference_and_lipid_profile_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(12)00267-5 DB - PRIME DP - Unbound Medicine ER -