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Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain.

Abstract

Baicalin, a major constituent of flavonoids isolated from Scutellariae Radix, has been previously confirmed to decrease the duration of immobility in mice exposed to the forced swimming test (FST) and tail suspension test (TST). However, its antidepressant effects and mechanisms are still seldom studied in chronic mild stress (CMS) model of depression. In the present study, we attempted to investigate the effects of baicalin on the depressive-like behavior, the mRNA expression and activity of cyclooxygenase-2 (COX-2), as well as prostaglandin E(2) (PGE(2)) levels in the frontal cortex and hippocampus. Moreover, the serum corticosterone levels were also examined. We found that CMS procedure not only decreased the sucrose preference and increased serum corticosterone levels, but also elevated the activity and mRNA expression of COX-2, and increased PGE(2) levels in rat brain regions. Treatment with baicalin (10, 20, 40 mg/kg) prevented these abnormalities induced by CMS. These results confirmed that baicalin exerted antidepressant-like effects, and suggested its mechanisms at least partially related to decease COX-2 activity and expression, subsequently resulted in reduction of PGE(2) levels in brain. Our findings may provide a new aspect to understand the antidepressant action of baicalin, which is targeted on the COX-2 system in brain.

Authors+Show Affiliations

College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan province, PR China. liyucheng@hactcm.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23022674

Citation

Li, Yu-Cheng, et al. "Chronic Treatment With Baicalin Prevents the Chronic Mild Stress-induced Depressive-like Behavior: Involving the Inhibition of Cyclooxygenase-2 in Rat Brain." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 40, 2013, pp. 138-43.
Li YC, Shen JD, Li J, et al. Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:138-43.
Li, Y. C., Shen, J. D., Li, J., Wang, R., Jiao, S., & Yi, L. T. (2013). Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. Progress in Neuro-psychopharmacology & Biological Psychiatry, 40, 138-43. https://doi.org/10.1016/j.pnpbp.2012.09.007
Li YC, et al. Chronic Treatment With Baicalin Prevents the Chronic Mild Stress-induced Depressive-like Behavior: Involving the Inhibition of Cyclooxygenase-2 in Rat Brain. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:138-43. PubMed PMID: 23022674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. AU - Li,Yu-Cheng, AU - Shen,Ji-Duo, AU - Li,Jing, AU - Wang,Rui, AU - Jiao,Shuo, AU - Yi,Li-Tao, Y1 - 2012/09/26/ PY - 2012/07/23/received PY - 2012/09/12/revised PY - 2012/09/18/accepted PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/3/27/medline SP - 138 EP - 43 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 40 N2 - Baicalin, a major constituent of flavonoids isolated from Scutellariae Radix, has been previously confirmed to decrease the duration of immobility in mice exposed to the forced swimming test (FST) and tail suspension test (TST). However, its antidepressant effects and mechanisms are still seldom studied in chronic mild stress (CMS) model of depression. In the present study, we attempted to investigate the effects of baicalin on the depressive-like behavior, the mRNA expression and activity of cyclooxygenase-2 (COX-2), as well as prostaglandin E(2) (PGE(2)) levels in the frontal cortex and hippocampus. Moreover, the serum corticosterone levels were also examined. We found that CMS procedure not only decreased the sucrose preference and increased serum corticosterone levels, but also elevated the activity and mRNA expression of COX-2, and increased PGE(2) levels in rat brain regions. Treatment with baicalin (10, 20, 40 mg/kg) prevented these abnormalities induced by CMS. These results confirmed that baicalin exerted antidepressant-like effects, and suggested its mechanisms at least partially related to decease COX-2 activity and expression, subsequently resulted in reduction of PGE(2) levels in brain. Our findings may provide a new aspect to understand the antidepressant action of baicalin, which is targeted on the COX-2 system in brain. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/23022674/Chronic_treatment_with_baicalin_prevents_the_chronic_mild_stress_induced_depressive_like_behavior:_involving_the_inhibition_of_cyclooxygenase_2_in_rat_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(12)00245-X DB - PRIME DP - Unbound Medicine ER -