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Genipin-crosslinked chitosan scaffolds and its efficacy in releasing anti-inflammatory medicine.
Biomed Mater Eng. 2012; 22(5):321-32.BM

Abstract

Controlled release carriers are often made into microspheres or tablets. Systematic and quantitative characterization of porous tissue engineered scaffolds as release carriers have not been done. Chitosan and chitosan crosslinked with various concentrations of genipin were made into porous tissue engineered scaffolds. Their thermal and enzymatic stabilities, hydrophobicities, porous structures, swelling and release properties, and compressional moduli were measured. The effects of scaffolds loaded with pentoxifylline (PTX) in suppressing inflammatory reactions in vitro were quantified.Fourier Transform Infrared spectra showed new bond formation after crosslinking chitosan with genipin. As genipin increased from 0.01% to 0.1%, the crosslinked chitosan scaffolds swelled 0.5% to 1.8% less, had 1.9-5% decrease in PTX release efficiencies, became less wettable, were less favorable for initial cell attachment, had 4-20% increase in Young's modulus and were more resistant to enzymatic degradation. In vitro tests showed that when PTX was released more slowly from crosslinked scaffolds, PTX became more effective in suppressing macrophage cells from releasing IL-6 and TNF-α.

Authors+Show Affiliations

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan. hbrunken@ntut.edu.twNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23023149

Citation

Lin, Hsin-Yi, and Chih-Tsung Yeh. "Genipin-crosslinked Chitosan Scaffolds and Its Efficacy in Releasing Anti-inflammatory Medicine." Bio-medical Materials and Engineering, vol. 22, no. 5, 2012, pp. 321-32.
Lin HY, Yeh CT. Genipin-crosslinked chitosan scaffolds and its efficacy in releasing anti-inflammatory medicine. Biomed Mater Eng. 2012;22(5):321-32.
Lin, H. Y., & Yeh, C. T. (2012). Genipin-crosslinked chitosan scaffolds and its efficacy in releasing anti-inflammatory medicine. Bio-medical Materials and Engineering, 22(5), 321-32. https://doi.org/10.3233/BME-2012-0722
Lin HY, Yeh CT. Genipin-crosslinked Chitosan Scaffolds and Its Efficacy in Releasing Anti-inflammatory Medicine. Biomed Mater Eng. 2012;22(5):321-32. PubMed PMID: 23023149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genipin-crosslinked chitosan scaffolds and its efficacy in releasing anti-inflammatory medicine. AU - Lin,Hsin-Yi, AU - Yeh,Chih-Tsung, PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/2/12/medline SP - 321 EP - 32 JF - Bio-medical materials and engineering JO - Biomed Mater Eng VL - 22 IS - 5 N2 - Controlled release carriers are often made into microspheres or tablets. Systematic and quantitative characterization of porous tissue engineered scaffolds as release carriers have not been done. Chitosan and chitosan crosslinked with various concentrations of genipin were made into porous tissue engineered scaffolds. Their thermal and enzymatic stabilities, hydrophobicities, porous structures, swelling and release properties, and compressional moduli were measured. The effects of scaffolds loaded with pentoxifylline (PTX) in suppressing inflammatory reactions in vitro were quantified.Fourier Transform Infrared spectra showed new bond formation after crosslinking chitosan with genipin. As genipin increased from 0.01% to 0.1%, the crosslinked chitosan scaffolds swelled 0.5% to 1.8% less, had 1.9-5% decrease in PTX release efficiencies, became less wettable, were less favorable for initial cell attachment, had 4-20% increase in Young's modulus and were more resistant to enzymatic degradation. In vitro tests showed that when PTX was released more slowly from crosslinked scaffolds, PTX became more effective in suppressing macrophage cells from releasing IL-6 and TNF-α. SN - 1878-3619 UR - https://www.unboundmedicine.com/medline/citation/23023149/Genipin_crosslinked_chitosan_scaffolds_and_its_efficacy_in_releasing_anti_inflammatory_medicine_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/BME-2012-0722 DB - PRIME DP - Unbound Medicine ER -