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Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.

Abstract

Our aim was to assess the relationship of the Val158Met polymorphism to pain, anxiety, depression, functional ability, and pressure pain sensitivity in women with fibromyalgia (FMS). One hundred (n = 100) women with FMS diagnosed according to the American College of Rheumatology criteria participated. A numerical pain rate scale (0-10) was used to assess the intensity of pain; the Hospital Anxiety and Depression Scale was calculated to determine anxiety and depression; and functional ability was determined with the Fibromyalgia Impact Questionnaire. Further, pressure pain thresholds (PPTs) were bilaterally assessed over C5-C6 zygapophyseal joints, second metacarpal, and tibialis anterior muscles. Finally, after amplifying Val158Met polymorphisms by polymerase chain reaction, catechol-O-methyltransferase (COMT) genotype was divided into Val/Val, Val/Met, or Met/Met genotypes. Women with FMS with the Met/Met genotype exhibited higher disability (F = 11.836; P < .001), anxiety (F = 13.385; P < .001), and depression (F = 6.931; P = .002) than those with Val/Val and Val/Met genotypes. No differences for the intensity of widespread pain (F = .154; P = .857) and PPT levels over C5-C6 joints (F = 1.014; P = .336), second metacarpal (F = .216; P = .806), and tibialis anterior muscle (F = 1.179; P = .311) were found. Our results suggest that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS, because women carrying the Met/Met genotype show higher disability, depression, and anxiety but similar PPTs than those with Val/Met or Val/Val genotypes. This study is important because it strives to understand potential genetic factors that predispose some women with FMS to exhibit a more severe phenotypic expression of the disease. Future studies are needed to elucidate potential relevance of the differences.

PERSPECTIVE

This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. This study provides further evidence of potential genetic factors that predispose women with FMS to exhibit the disease more severely.

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  • Authors+Show Affiliations

    ,

    Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain. cesar.fernandez@urjc.es

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Amino Acid Substitution
    Anxiety
    Catechol O-Methyltransferase
    DNA
    Depression
    Disability Evaluation
    Female
    Fibromyalgia
    Genotype
    Humans
    Middle Aged
    Pain Measurement
    Polymorphism, Genetic
    Pressure
    Psychiatric Status Rating Scales
    Surveys and Questionnaires
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23025981

    Citation

    Fernández-de-Las-Peñas, César, et al. "Catechol-O-methyltransferase Val158Met Polymorphism Influences Anxiety, Depression, and Disability, but Not Pressure Pain Sensitivity, in Women With Fibromyalgia Syndrome." The Journal of Pain : Official Journal of the American Pain Society, vol. 13, no. 11, 2012, pp. 1068-74.
    Fernández-de-Las-Peñas C, Ambite-Quesada S, Gil-Crujera A, et al. Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome. J Pain. 2012;13(11):1068-74.
    Fernández-de-Las-Peñas, C., Ambite-Quesada, S., Gil-Crujera, A., Cigarán-Méndez, M., & Peñacoba-Puente, C. (2012). Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome. The Journal of Pain : Official Journal of the American Pain Society, 13(11), pp. 1068-74. doi:10.1016/j.jpain.2012.08.001.
    Fernández-de-Las-Peñas C, et al. Catechol-O-methyltransferase Val158Met Polymorphism Influences Anxiety, Depression, and Disability, but Not Pressure Pain Sensitivity, in Women With Fibromyalgia Syndrome. J Pain. 2012;13(11):1068-74. PubMed PMID: 23025981.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome. AU - Fernández-de-Las-Peñas,César, AU - Ambite-Quesada,Silvia, AU - Gil-Crujera,Antonio, AU - Cigarán-Méndez,Margarita, AU - Peñacoba-Puente,Cecilia, Y1 - 2012/09/29/ PY - 2012/05/25/received PY - 2012/07/16/revised PY - 2012/08/02/accepted PY - 2012/10/3/entrez PY - 2012/10/3/pubmed PY - 2013/4/16/medline SP - 1068 EP - 74 JF - The journal of pain : official journal of the American Pain Society JO - J Pain VL - 13 IS - 11 N2 - UNLABELLED: Our aim was to assess the relationship of the Val158Met polymorphism to pain, anxiety, depression, functional ability, and pressure pain sensitivity in women with fibromyalgia (FMS). One hundred (n = 100) women with FMS diagnosed according to the American College of Rheumatology criteria participated. A numerical pain rate scale (0-10) was used to assess the intensity of pain; the Hospital Anxiety and Depression Scale was calculated to determine anxiety and depression; and functional ability was determined with the Fibromyalgia Impact Questionnaire. Further, pressure pain thresholds (PPTs) were bilaterally assessed over C5-C6 zygapophyseal joints, second metacarpal, and tibialis anterior muscles. Finally, after amplifying Val158Met polymorphisms by polymerase chain reaction, catechol-O-methyltransferase (COMT) genotype was divided into Val/Val, Val/Met, or Met/Met genotypes. Women with FMS with the Met/Met genotype exhibited higher disability (F = 11.836; P < .001), anxiety (F = 13.385; P < .001), and depression (F = 6.931; P = .002) than those with Val/Val and Val/Met genotypes. No differences for the intensity of widespread pain (F = .154; P = .857) and PPT levels over C5-C6 joints (F = 1.014; P = .336), second metacarpal (F = .216; P = .806), and tibialis anterior muscle (F = 1.179; P = .311) were found. Our results suggest that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS, because women carrying the Met/Met genotype show higher disability, depression, and anxiety but similar PPTs than those with Val/Met or Val/Val genotypes. This study is important because it strives to understand potential genetic factors that predispose some women with FMS to exhibit a more severe phenotypic expression of the disease. Future studies are needed to elucidate potential relevance of the differences. PERSPECTIVE: This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. This study provides further evidence of potential genetic factors that predispose women with FMS to exhibit the disease more severely. SN - 1528-8447 UR - https://www.unboundmedicine.com/medline/citation/23025981/Catechol_O_methyltransferase_Val158Met_polymorphism_influences_anxiety_depression_and_disability_but_not_pressure_pain_sensitivity_in_women_with_fibromyalgia_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1526-5900(12)00754-7 DB - PRIME DP - Unbound Medicine ER -