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Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats.
J Nutr Biochem. 2013 Jun; 24(6):1041-52.JN

Abstract

We compared the cardiovascular, hepatic and metabolic responses to individual dietary n-3 fatty acids (α-linolenic acid, ALA; eicosapentaenoic acid, EPA; and docosahexaenoic acid, DHA) in a high-carbohydrate, high-fat diet-induced model of metabolic syndrome in rats. Additionally, we measured fatty acid composition of plasma, adipose tissue, liver, heart and skeletal muscle in these rats. The same dosages of ALA and EPA/DHA produced different physiological responses to decrease the risk factors for metabolic syndrome. ALA did not reduce total body fat but induced lipid redistribution away from the abdominal area and favorably improved glucose tolerance, insulin sensitivity, dyslipidemia, hypertension and left ventricular dimensions, contractility, volumes and stiffness. EPA and DHA increased sympathetic activation, reduced the abdominal adiposity and total body fat and attenuated insulin sensitivity, dyslipidemia, hypertension and left ventricular stiffness but not glucose tolerance. However, ALA, EPA and DHA all reduced inflammation in both the heart and the liver, cardiac fibrosis and hepatic steatosis. These effects were associated with complete suppression of stearoyl-CoA desaturase 1 activity. Since the physiological responses to EPA and DHA were similar, it is likely that the effects are mediated by DHA with EPA serving as a precursor. Also, ALA supplementation increased DHA concentrations but induced different physiological responses to EPA and DHA. This result strongly suggests that ALA has independent effects in metabolic syndrome, not relying on its metabolism to DHA.

Authors+Show Affiliations

School of Biomedical Sciences, The University of Queensland, Brisbane, 4072, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23026492

Citation

Poudyal, Hemant, et al. "Effects of ALA, EPA and DHA in High-carbohydrate, High-fat Diet-induced Metabolic Syndrome in Rats." The Journal of Nutritional Biochemistry, vol. 24, no. 6, 2013, pp. 1041-52.
Poudyal H, Panchal SK, Ward LC, et al. Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. J Nutr Biochem. 2013;24(6):1041-52.
Poudyal, H., Panchal, S. K., Ward, L. C., & Brown, L. (2013). Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. The Journal of Nutritional Biochemistry, 24(6), 1041-52. https://doi.org/10.1016/j.jnutbio.2012.07.014
Poudyal H, et al. Effects of ALA, EPA and DHA in High-carbohydrate, High-fat Diet-induced Metabolic Syndrome in Rats. J Nutr Biochem. 2013;24(6):1041-52. PubMed PMID: 23026492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. AU - Poudyal,Hemant, AU - Panchal,Sunil K, AU - Ward,Leigh C, AU - Brown,Lindsay, Y1 - 2012/09/29/ PY - 2012/02/19/received PY - 2012/06/30/revised PY - 2012/07/11/accepted PY - 2012/10/3/entrez PY - 2012/10/3/pubmed PY - 2014/4/25/medline SP - 1041 EP - 52 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 24 IS - 6 N2 - We compared the cardiovascular, hepatic and metabolic responses to individual dietary n-3 fatty acids (α-linolenic acid, ALA; eicosapentaenoic acid, EPA; and docosahexaenoic acid, DHA) in a high-carbohydrate, high-fat diet-induced model of metabolic syndrome in rats. Additionally, we measured fatty acid composition of plasma, adipose tissue, liver, heart and skeletal muscle in these rats. The same dosages of ALA and EPA/DHA produced different physiological responses to decrease the risk factors for metabolic syndrome. ALA did not reduce total body fat but induced lipid redistribution away from the abdominal area and favorably improved glucose tolerance, insulin sensitivity, dyslipidemia, hypertension and left ventricular dimensions, contractility, volumes and stiffness. EPA and DHA increased sympathetic activation, reduced the abdominal adiposity and total body fat and attenuated insulin sensitivity, dyslipidemia, hypertension and left ventricular stiffness but not glucose tolerance. However, ALA, EPA and DHA all reduced inflammation in both the heart and the liver, cardiac fibrosis and hepatic steatosis. These effects were associated with complete suppression of stearoyl-CoA desaturase 1 activity. Since the physiological responses to EPA and DHA were similar, it is likely that the effects are mediated by DHA with EPA serving as a precursor. Also, ALA supplementation increased DHA concentrations but induced different physiological responses to EPA and DHA. This result strongly suggests that ALA has independent effects in metabolic syndrome, not relying on its metabolism to DHA. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/23026492/Effects_of_ALA_EPA_and_DHA_in_high_carbohydrate_high_fat_diet_induced_metabolic_syndrome_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(12)00207-0 DB - PRIME DP - Unbound Medicine ER -