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The influence of nutritional factors on the prognosis of multiple sclerosis.
Nat Rev Neurol 2012; 8(12):678-89NR

Abstract

The effect of nutrition and dietary supplements on the course of multiple sclerosis (MS) is a topic of great interest to both patients and clinicians. In particular, vitamin D status has been shown to influence both the incidence and the course of MS. High vitamin D levels are probably protective against the development of MS, although the efficacy of vitamin D supplementation in slowing progression of MS remains to be established. The influence of polyunsaturated fatty acids (PUFAs) on the development and course of MS has also long been under investigation. Small clinical trials suggest a modest reduction in the severity and duration of relapses in patients with MS receiving PUFA supplements. Other nutritional factors have been evaluated for their effect on MS disease progression, including milk proteins, gluten, probiotics, antioxidants (uric acid, vitamins A, C and E, lipoic acid), polyphenols, Ginkgo biloba extracts and curcumin. However, further studies are needed to evaluate the effects of these dietary components on the relapse rate and progression of MS. This Review gives an overview of the literature on the nutritional factors most commonly implicated as having an effect on MS and discusses the biological rationale that is thought to underlie their influence.

Authors+Show Affiliations

Department of Neurology, Division of Neuroimmunology and Neurological Infections, John Hopkins University School of Medicine, Pathology Building Room 627, 600 North Wolfe Street, Baltimore, MD 21287, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23026980

Citation

von Geldern, Gloria, and Ellen M. Mowry. "The Influence of Nutritional Factors On the Prognosis of Multiple Sclerosis." Nature Reviews. Neurology, vol. 8, no. 12, 2012, pp. 678-89.
von Geldern G, Mowry EM. The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol. 2012;8(12):678-89.
von Geldern, G., & Mowry, E. M. (2012). The influence of nutritional factors on the prognosis of multiple sclerosis. Nature Reviews. Neurology, 8(12), pp. 678-89. doi:10.1038/nrneurol.2012.194.
von Geldern G, Mowry EM. The Influence of Nutritional Factors On the Prognosis of Multiple Sclerosis. Nat Rev Neurol. 2012;8(12):678-89. PubMed PMID: 23026980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of nutritional factors on the prognosis of multiple sclerosis. AU - von Geldern,Gloria, AU - Mowry,Ellen M, Y1 - 2012/10/02/ PY - 2012/10/3/entrez PY - 2012/10/3/pubmed PY - 2013/7/23/medline SP - 678 EP - 89 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 8 IS - 12 N2 - The effect of nutrition and dietary supplements on the course of multiple sclerosis (MS) is a topic of great interest to both patients and clinicians. In particular, vitamin D status has been shown to influence both the incidence and the course of MS. High vitamin D levels are probably protective against the development of MS, although the efficacy of vitamin D supplementation in slowing progression of MS remains to be established. The influence of polyunsaturated fatty acids (PUFAs) on the development and course of MS has also long been under investigation. Small clinical trials suggest a modest reduction in the severity and duration of relapses in patients with MS receiving PUFA supplements. Other nutritional factors have been evaluated for their effect on MS disease progression, including milk proteins, gluten, probiotics, antioxidants (uric acid, vitamins A, C and E, lipoic acid), polyphenols, Ginkgo biloba extracts and curcumin. However, further studies are needed to evaluate the effects of these dietary components on the relapse rate and progression of MS. This Review gives an overview of the literature on the nutritional factors most commonly implicated as having an effect on MS and discusses the biological rationale that is thought to underlie their influence. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/23026980/The_influence_of_nutritional_factors_on_the_prognosis_of_multiple_sclerosis_ L2 - http://dx.doi.org/10.1038/nrneurol.2012.194 DB - PRIME DP - Unbound Medicine ER -