Tags

Type your tag names separated by a space and hit enter

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease.

Abstract

Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the brain vascular system may contribute in a significant way to the onset and progression of cognitive decline and the development of a chronic neurodegenerative process associated with accumulation of amyloid β-peptide (Aβ) in brain and cerebral vessels in AD individuals and AD animal models. Here, we review the role of the neurovascular unit and molecular mechanisms in cerebral vascular cells behind the pathogenesis of AD. In particular, we focus on blood-brain barrier (BBB) dysfunction, decreased cerebral blood flow, and impaired vascular clearance of Aβ from brain. The data reviewed here support an essential role of the neurovascular and BBB mechanisms in AD pathogenesis.

Authors+Show Affiliations

Center for Neurodegenerative and Vascular Brain Disorders and Interdisciplinary Program in Dementia Research, Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

23028132

Citation

Sagare, Abhay P., et al. "Neurovascular Dysfunction and Faulty Amyloid Β-peptide Clearance in Alzheimer Disease." Cold Spring Harbor Perspectives in Medicine, vol. 2, no. 10, 2012.
Sagare AP, Bell RD, Zlokovic BV. Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(10).
Sagare, A. P., Bell, R. D., & Zlokovic, B. V. (2012). Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine, 2(10), doi:10.1101/cshperspect.a011452.
Sagare AP, Bell RD, Zlokovic BV. Neurovascular Dysfunction and Faulty Amyloid Β-peptide Clearance in Alzheimer Disease. Cold Spring Harb Perspect Med. 2012 Oct 1;2(10) PubMed PMID: 23028132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. AU - Sagare,Abhay P, AU - Bell,Robert D, AU - Zlokovic,Berislav V, Y1 - 2012/10/01/ PY - 2012/10/3/entrez PY - 2012/10/3/pubmed PY - 2013/4/2/medline JF - Cold Spring Harbor perspectives in medicine JO - Cold Spring Harb Perspect Med VL - 2 IS - 10 N2 - Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the brain vascular system may contribute in a significant way to the onset and progression of cognitive decline and the development of a chronic neurodegenerative process associated with accumulation of amyloid β-peptide (Aβ) in brain and cerebral vessels in AD individuals and AD animal models. Here, we review the role of the neurovascular unit and molecular mechanisms in cerebral vascular cells behind the pathogenesis of AD. In particular, we focus on blood-brain barrier (BBB) dysfunction, decreased cerebral blood flow, and impaired vascular clearance of Aβ from brain. The data reviewed here support an essential role of the neurovascular and BBB mechanisms in AD pathogenesis. SN - 2157-1422 UR - https://www.unboundmedicine.com/medline/citation/23028132/Neurovascular_dysfunction_and_faulty_amyloid_β_peptide_clearance_in_Alzheimer_disease_ L2 - http://perspectivesinmedicine.cshlp.org/cgi/pmidlookup?view=long&pmid=23028132 DB - PRIME DP - Unbound Medicine ER -