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Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice.
PLoS One 2012; 7(9):e46574Plos

Abstract

Polydatin is one of main compounds in Polygonum cuspidatum, a plant with both medicinal and nutritional value. The possible hepatoprotective effects of polydatin on acute liver injury mice induced by carbon tetrachloride (CCl(4)) and the mechanisms involved were investigated. Intraperitoneal injection of CCl(4) (50 µl/kg) resulted in a significant increase in the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and hepatic malondialdehyde (MDA), also a marked enhancement in the expression of hepatic tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and nuclearfactor-kappa B (NF-κB). On the other hand, decreased glutathione (GSH) content and activities of glutathione transferase (GST), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were observed following CCl(4) exposure. Nevertheless, all of these phenotypes were evidently reversed by preadministration of polydatin for 5 continuous days. The mRNA and protein expression levels of hepatic growth factor-beta1 (TGF-β(1)) were enhanced further by polydatin. These results suggest that polydatin protects mice against CCl(4)-induced liver injury through antioxidant stress and antiinflammatory effects. Polydatin may be an effective hepatoprotective agent and a promising candidate for the treatment of oxidative stress- and inflammation-related diseases.

Authors+Show Affiliations

Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23029551

Citation

Zhang, Hong, et al. "Protective Effects of Polydatin From Polygonum Cuspidatum Against Carbon Tetrachloride-induced Liver Injury in Mice." PloS One, vol. 7, no. 9, 2012, pp. e46574.
Zhang H, Yu CH, Jiang YP, et al. Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. PLoS ONE. 2012;7(9):e46574.
Zhang, H., Yu, C. H., Jiang, Y. P., Peng, C., He, K., Tang, J. Y., & Xin, H. L. (2012). Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. PloS One, 7(9), pp. e46574. doi:10.1371/journal.pone.0046574.
Zhang H, et al. Protective Effects of Polydatin From Polygonum Cuspidatum Against Carbon Tetrachloride-induced Liver Injury in Mice. PLoS ONE. 2012;7(9):e46574. PubMed PMID: 23029551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. AU - Zhang,Hong, AU - Yu,Cheng-Hao, AU - Jiang,Yi-Ping, AU - Peng,Cheng, AU - He,Kun, AU - Tang,Jian-Yuan, AU - Xin,Hai-Liang, Y1 - 2012/09/28/ PY - 2012/05/24/received PY - 2012/08/31/accepted PY - 2012/10/3/entrez PY - 2012/10/3/pubmed PY - 2013/2/21/medline SP - e46574 EP - e46574 JF - PloS one JO - PLoS ONE VL - 7 IS - 9 N2 - Polydatin is one of main compounds in Polygonum cuspidatum, a plant with both medicinal and nutritional value. The possible hepatoprotective effects of polydatin on acute liver injury mice induced by carbon tetrachloride (CCl(4)) and the mechanisms involved were investigated. Intraperitoneal injection of CCl(4) (50 µl/kg) resulted in a significant increase in the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and hepatic malondialdehyde (MDA), also a marked enhancement in the expression of hepatic tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and nuclearfactor-kappa B (NF-κB). On the other hand, decreased glutathione (GSH) content and activities of glutathione transferase (GST), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were observed following CCl(4) exposure. Nevertheless, all of these phenotypes were evidently reversed by preadministration of polydatin for 5 continuous days. The mRNA and protein expression levels of hepatic growth factor-beta1 (TGF-β(1)) were enhanced further by polydatin. These results suggest that polydatin protects mice against CCl(4)-induced liver injury through antioxidant stress and antiinflammatory effects. Polydatin may be an effective hepatoprotective agent and a promising candidate for the treatment of oxidative stress- and inflammation-related diseases. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23029551/Protective_effects_of_polydatin_from_Polygonum_cuspidatum_against_carbon_tetrachloride_induced_liver_injury_in_mice_ L2 - http://dx.plos.org/10.1371/journal.pone.0046574 DB - PRIME DP - Unbound Medicine ER -