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Enhanced activity of carvacrol against biofilm of Staphylococcus aureus and Staphylococcus epidermidis in an acidic environment.
APMIS. 2012 Dec; 120(12):967-73.A

Abstract

Carvacrol is an antimicrobial monoterpenic phenol which occurs in many plant essential oils. The aim of this study was to investigate its activity at acidic pH on staphylococcal forming and yet established biofilms, with particular focus to improve its effectiveness on Staphylococcus epidermidis biofilm. The results showed that the subinhibitory doses (1/2, 1/4 and 1/8 MIC) of carvacrol determined a higher reduction of S. epidermidis biofilm formation than that observed at neutral pH. A potentiated inhibitory effect was also observed on established biofilm, carvacrol caused either a strong reduction of biomass (>50%) and bacteria attached to polystyrene (>7 log units). The images of scanning electron microscopy and the gas-chromatographic analysis support these results. The development of acidic formulations containing carvacrol could be an important tool to control the staphylococcal biofilm in the medical and food environment.

Authors+Show Affiliations

Pharmaco-Biological Department, University of Messina, 98168 Messina, Italy. anostro@unime.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23030501

Citation

Nostro, Antonia, et al. "Enhanced Activity of Carvacrol Against Biofilm of Staphylococcus Aureus and Staphylococcus Epidermidis in an Acidic Environment." APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, vol. 120, no. 12, 2012, pp. 967-73.
Nostro A, Cellini L, Zimbalatti V, et al. Enhanced activity of carvacrol against biofilm of Staphylococcus aureus and Staphylococcus epidermidis in an acidic environment. APMIS. 2012;120(12):967-73.
Nostro, A., Cellini, L., Zimbalatti, V., Blanco, A. R., Marino, A., Pizzimenti, F., Di Giulio, M., & Bisignano, G. (2012). Enhanced activity of carvacrol against biofilm of Staphylococcus aureus and Staphylococcus epidermidis in an acidic environment. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 120(12), 967-73. https://doi.org/10.1111/j.1600-0463.2012.02928.x
Nostro A, et al. Enhanced Activity of Carvacrol Against Biofilm of Staphylococcus Aureus and Staphylococcus Epidermidis in an Acidic Environment. APMIS. 2012;120(12):967-73. PubMed PMID: 23030501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced activity of carvacrol against biofilm of Staphylococcus aureus and Staphylococcus epidermidis in an acidic environment. AU - Nostro,Antonia, AU - Cellini,Luigina, AU - Zimbalatti,Vincenzo, AU - Blanco,Anna Rita, AU - Marino,Andreana, AU - Pizzimenti,Francesco, AU - Di Giulio,Mara, AU - Bisignano,Giuseppe, Y1 - 2012/07/05/ PY - 2012/02/05/received PY - 2012/05/01/accepted PY - 2012/10/4/entrez PY - 2012/10/4/pubmed PY - 2013/1/12/medline SP - 967 EP - 73 JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica JO - APMIS VL - 120 IS - 12 N2 - Carvacrol is an antimicrobial monoterpenic phenol which occurs in many plant essential oils. The aim of this study was to investigate its activity at acidic pH on staphylococcal forming and yet established biofilms, with particular focus to improve its effectiveness on Staphylococcus epidermidis biofilm. The results showed that the subinhibitory doses (1/2, 1/4 and 1/8 MIC) of carvacrol determined a higher reduction of S. epidermidis biofilm formation than that observed at neutral pH. A potentiated inhibitory effect was also observed on established biofilm, carvacrol caused either a strong reduction of biomass (>50%) and bacteria attached to polystyrene (>7 log units). The images of scanning electron microscopy and the gas-chromatographic analysis support these results. The development of acidic formulations containing carvacrol could be an important tool to control the staphylococcal biofilm in the medical and food environment. SN - 1600-0463 UR - https://www.unboundmedicine.com/medline/citation/23030501/Enhanced_activity_of_carvacrol_against_biofilm_of_Staphylococcus_aureus_and_Staphylococcus_epidermidis_in_an_acidic_environment_ L2 - https://doi.org/10.1111/j.1600-0463.2012.02928.x DB - PRIME DP - Unbound Medicine ER -