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Depression and the risk of psoriasis in US women.
J Eur Acad Dermatol Venereol 2013; 27(9):1163-7JE

Abstract

BACKGROUND

Depression is a common mental health condition that has been associated with psoriasis. In the absence of prospective data, it remains unclear whether depression precedes psoriasis as a risk factor.

OBJECTIVES

To examine the association between depression and the risk of new-onset psoriasis.

METHODS

A prospective cohort of 86 880 US female nurses, The Nurses' Health Study II, was followed up from 1993 to 2005. Participants reported anti-depressant use and completed the Mental Health Index (MHI), a subscale of the Short-Form 36 in 1993. The MHI assessed for depression and scores was categorized into four strata: 0-52, 53-75, 76-85 and 86-100, with lower scores associated with increasing depressive symptoms. We excluded participants with a history of psoriasis prior to 1993. A self-report of incident physician-diagnosed psoriasis constituted the main outcome measure. For a sensitivity analysis, we had a subset of confirmed psoriasis cases.

RESULTS

Depression was associated with an increased risk of incident psoriasis. Compared to women in the non-depressed group (MHI 86-100), women who reported either having high depressive symptomatology (MHI scores < 52) or who were on anti-depressants had a multivariate relative risk (RR) of 1.59 for developing subsequent psoriasis (95% confidence interval [CI], 1.21-2.08). These associations became stronger among confirmed psoriasis cases.

CONCLUSIONS

We found that depression was independently associated with an increased risk of psoriasis in this population of US women.

Authors+Show Affiliations

Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23030685

Citation

Dominguez, P L., et al. "Depression and the Risk of Psoriasis in US Women." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 27, no. 9, 2013, pp. 1163-7.
Dominguez PL, Han J, Li T, et al. Depression and the risk of psoriasis in US women. J Eur Acad Dermatol Venereol. 2013;27(9):1163-7.
Dominguez, P. L., Han, J., Li, T., Ascherio, A., & Qureshi, A. A. (2013). Depression and the risk of psoriasis in US women. Journal of the European Academy of Dermatology and Venereology : JEADV, 27(9), pp. 1163-7. doi:10.1111/j.1468-3083.2012.04703.x.
Dominguez PL, et al. Depression and the Risk of Psoriasis in US Women. J Eur Acad Dermatol Venereol. 2013;27(9):1163-7. PubMed PMID: 23030685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and the risk of psoriasis in US women. AU - Dominguez,P L, AU - Han,J, AU - Li,T, AU - Ascherio,A, AU - Qureshi,A A, Y1 - 2012/10/03/ PY - 2012/10/4/entrez PY - 2012/10/4/pubmed PY - 2013/10/29/medline SP - 1163 EP - 7 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 27 IS - 9 N2 - BACKGROUND: Depression is a common mental health condition that has been associated with psoriasis. In the absence of prospective data, it remains unclear whether depression precedes psoriasis as a risk factor. OBJECTIVES: To examine the association between depression and the risk of new-onset psoriasis. METHODS: A prospective cohort of 86 880 US female nurses, The Nurses' Health Study II, was followed up from 1993 to 2005. Participants reported anti-depressant use and completed the Mental Health Index (MHI), a subscale of the Short-Form 36 in 1993. The MHI assessed for depression and scores was categorized into four strata: 0-52, 53-75, 76-85 and 86-100, with lower scores associated with increasing depressive symptoms. We excluded participants with a history of psoriasis prior to 1993. A self-report of incident physician-diagnosed psoriasis constituted the main outcome measure. For a sensitivity analysis, we had a subset of confirmed psoriasis cases. RESULTS: Depression was associated with an increased risk of incident psoriasis. Compared to women in the non-depressed group (MHI 86-100), women who reported either having high depressive symptomatology (MHI scores < 52) or who were on anti-depressants had a multivariate relative risk (RR) of 1.59 for developing subsequent psoriasis (95% confidence interval [CI], 1.21-2.08). These associations became stronger among confirmed psoriasis cases. CONCLUSIONS: We found that depression was independently associated with an increased risk of psoriasis in this population of US women. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/23030685/Depression_and_the_risk_of_psoriasis_in_US_women_ L2 - https://doi.org/10.1111/j.1468-3083.2012.04703.x DB - PRIME DP - Unbound Medicine ER -