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Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population.
Transl Psychiatry. 2012 Oct 02; 2:e164.TP

Abstract

The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P < 0.001), and in adherence between HC and MCI subjects (P < 0.05). MeDi is associated with change in Mini-Mental State Examination score over an 18-month time period (P < 0.05) in HCs. We conclude that in this Australian cohort, AD and MCI participants had a lower adherence to the MeDi than HC participants.

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Authors+Show Affiliations

Gardener S
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Gu Y
No affiliation info available
Rainey-Smith SR
No affiliation info available
Keogh JB
No affiliation info available
Clifton PM
No affiliation info available
Mathieson SL
No affiliation info available
Taddei K
No affiliation info available
Mondal A
No affiliation info available
Ward VK
No affiliation info available
Scarmeas N
No affiliation info available
Barnes M
No affiliation info available
Ellis KA
No affiliation info available
Head R
No affiliation info available
Masters CL
No affiliation info available
Ames D
No affiliation info available
Macaulay SL
No affiliation info available
Rowe CC
No affiliation info available
Szoeke C
No affiliation info available
Martins RN
No affiliation info available
AIBL Research Group
No affiliation info available

MeSH

AgedAlzheimer DiseaseAustraliaCognitive DysfunctionCohort StudiesCross-Sectional StudiesDiet, MediterraneanFemaleFollow-Up StudiesGeriatric AssessmentHumansMaleNeuropsychological TestsPatient ComplianceRisk FactorsSurveys and Questionnaires

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23032941

Citation

Gardener, S, et al. "Adherence to a Mediterranean Diet and Alzheimer's Disease Risk in an Australian Population." Translational Psychiatry, vol. 2, 2012, pp. e164.
Gardener S, Gu Y, Rainey-Smith SR, et al. Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Transl Psychiatry. 2012;2:e164.
Gardener, S., Gu, Y., Rainey-Smith, S. R., Keogh, J. B., Clifton, P. M., Mathieson, S. L., Taddei, K., Mondal, A., Ward, V. K., Scarmeas, N., Barnes, M., Ellis, K. A., Head, R., Masters, C. L., Ames, D., Macaulay, S. L., Rowe, C. C., Szoeke, C., & Martins, R. N. (2012). Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry, 2, e164. https://doi.org/10.1038/tp.2012.91
Gardener S, et al. Adherence to a Mediterranean Diet and Alzheimer's Disease Risk in an Australian Population. Transl Psychiatry. 2012 Oct 2;2:e164. PubMed PMID: 23032941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. AU - Gardener,S, AU - Gu,Y, AU - Rainey-Smith,S R, AU - Keogh,J B, AU - Clifton,P M, AU - Mathieson,S L, AU - Taddei,K, AU - Mondal,A, AU - Ward,V K, AU - Scarmeas,N, AU - Barnes,M, AU - Ellis,K A, AU - Head,R, AU - Masters,C L, AU - Ames,D, AU - Macaulay,S L, AU - Rowe,C C, AU - Szoeke,C, AU - Martins,R N, AU - ,, Y1 - 2012/10/02/ PY - 2012/10/4/entrez PY - 2012/10/4/pubmed PY - 2013/3/15/medline SP - e164 EP - e164 JF - Translational psychiatry JO - Transl Psychiatry VL - 2 N2 - The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P < 0.001), and in adherence between HC and MCI subjects (P < 0.05). MeDi is associated with change in Mini-Mental State Examination score over an 18-month time period (P < 0.05) in HCs. We conclude that in this Australian cohort, AD and MCI participants had a lower adherence to the MeDi than HC participants. SN - 2158-3188 UR - https://www.unboundmedicine.com/medline/citation/23032941/Adherence_to_a_Mediterranean_diet_and_Alzheimer's_disease_risk_in_an_Australian_population_ L2 - https://doi.org/10.1038/tp.2012.91 DB - PRIME DP - Unbound Medicine ER -