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Exercise-induced insulin-like growth factor I system concentrations after training in women.
Med Sci Sports Exerc. 2013 Mar; 45(3):420-8.MS

Abstract

INTRODUCTION

This study examined the effects of short-term physical training on the acute hormonal response (i.e., growth hormone, total and free insulin-like growth factor I [IGF-I], and IGF binding proteins [IGFBP]-1, IGFBP-2, and IGFBP-3) to resistance exercise (RE) in women.

METHODS

Forty-six women (20.3 ± 0.3 yr, mass = 64.1 ± 7.3 kg, height = 165.7 ± 1.0 cm) were randomly assigned to an endurance training (E), resistance training (R), combined training (R + E), or control (C) group for 8wk. Subjects completed a standardized bout of RE (six sets of back squats at 10 repetition maximum) before and after training. Blood samples were obtained at rest (PRE), after the third set, immediately postexercise (POST), and at 15 min and 30 min after exercise.

RESULTS

Acute RE significantly increased (P < 0.05) serum growth hormone (mean ± SD; change from PRE to POST = +10.9 ± 7.5 μg·L-1), total IGF-I (+66.1 ± 25.4 μg·L-1), IGFBP-1 (+2.5 ± 3.1 μg·L-1), IGFBP-2 (+86.0 ± 86.8 μg·L-1), and IGFBP-3 (+0.69 ± 0.25 mg·L-1) concentrations and decreased free IGF-I concentrations (-0.14 ± 0.21 μg·L-1). After 8 wk of training, total IGF-I concentrations were significantly increased (change in POST concentrations from week 0 to week 8 = +82.5 ± 120.8 μg·L-1), and IGFBP-1 concentrations were significantly decreased (-6.7 ± 13.6 μg·L-1) during exercise in groups that participated in resistance training (R and R + E); no significant changes were seen after E or C.

CONCLUSIONS

Participation in resistance training increased total IGF-I and reduced IGFBP-1 concentrations during acute RE, indicating exercise mode-specific adaptations in the circulating IGF-I system.

Authors+Show Affiliations

Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23034644

Citation

Gregory, Sara M., et al. "Exercise-induced Insulin-like Growth Factor I System Concentrations After Training in Women." Medicine and Science in Sports and Exercise, vol. 45, no. 3, 2013, pp. 420-8.
Gregory SM, Spiering BA, Alemany JA, et al. Exercise-induced insulin-like growth factor I system concentrations after training in women. Med Sci Sports Exerc. 2013;45(3):420-8.
Gregory, S. M., Spiering, B. A., Alemany, J. A., Tuckow, A. P., Rarick, K. R., Staab, J. S., Hatfield, D. L., Kraemer, W. J., Maresh, C. M., & Nindl, B. C. (2013). Exercise-induced insulin-like growth factor I system concentrations after training in women. Medicine and Science in Sports and Exercise, 45(3), 420-8. https://doi.org/10.1249/MSS.0b013e3182750bd4
Gregory SM, et al. Exercise-induced Insulin-like Growth Factor I System Concentrations After Training in Women. Med Sci Sports Exerc. 2013;45(3):420-8. PubMed PMID: 23034644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise-induced insulin-like growth factor I system concentrations after training in women. AU - Gregory,Sara M, AU - Spiering,Barry A, AU - Alemany,Joseph A, AU - Tuckow,Alexander P, AU - Rarick,Kevin R, AU - Staab,Jeffery S, AU - Hatfield,Disa L, AU - Kraemer,William J, AU - Maresh,Carl M, AU - Nindl,Bradley C, PY - 2012/10/5/entrez PY - 2012/10/5/pubmed PY - 2013/9/27/medline SP - 420 EP - 8 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 45 IS - 3 N2 - INTRODUCTION: This study examined the effects of short-term physical training on the acute hormonal response (i.e., growth hormone, total and free insulin-like growth factor I [IGF-I], and IGF binding proteins [IGFBP]-1, IGFBP-2, and IGFBP-3) to resistance exercise (RE) in women. METHODS: Forty-six women (20.3 ± 0.3 yr, mass = 64.1 ± 7.3 kg, height = 165.7 ± 1.0 cm) were randomly assigned to an endurance training (E), resistance training (R), combined training (R + E), or control (C) group for 8wk. Subjects completed a standardized bout of RE (six sets of back squats at 10 repetition maximum) before and after training. Blood samples were obtained at rest (PRE), after the third set, immediately postexercise (POST), and at 15 min and 30 min after exercise. RESULTS: Acute RE significantly increased (P < 0.05) serum growth hormone (mean ± SD; change from PRE to POST = +10.9 ± 7.5 μg·L-1), total IGF-I (+66.1 ± 25.4 μg·L-1), IGFBP-1 (+2.5 ± 3.1 μg·L-1), IGFBP-2 (+86.0 ± 86.8 μg·L-1), and IGFBP-3 (+0.69 ± 0.25 mg·L-1) concentrations and decreased free IGF-I concentrations (-0.14 ± 0.21 μg·L-1). After 8 wk of training, total IGF-I concentrations were significantly increased (change in POST concentrations from week 0 to week 8 = +82.5 ± 120.8 μg·L-1), and IGFBP-1 concentrations were significantly decreased (-6.7 ± 13.6 μg·L-1) during exercise in groups that participated in resistance training (R and R + E); no significant changes were seen after E or C. CONCLUSIONS: Participation in resistance training increased total IGF-I and reduced IGFBP-1 concentrations during acute RE, indicating exercise mode-specific adaptations in the circulating IGF-I system. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/23034644/Exercise_induced_insulin_like_growth_factor_I_system_concentrations_after_training_in_women_ L2 - http://dx.doi.org/10.1249/MSS.0b013e3182750bd4 DB - PRIME DP - Unbound Medicine ER -