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Concentration ratios of methamphetamine to amphetamine in blood can help to distinguish use of methamphetamine from various mixtures of the two stimulants.
J Anal Toxicol 2012 Nov-Dec; 36(9):634-7JA

Abstract

Using a forensic toxicology database, the authors investigated cases of driving under the influence of drugs (DUID) if methamphetamine (MA) was identified in the blood samples (N = 9,310). The concentrations of MA and amphetamine (AM) in blood were determined after liquid-liquid extraction by gas chromatography-mass spectrometry at limits of quantitation of 0.03 mg/L for both stimulants. In 814 cases, AM was negative in blood and MA was positive at mean (median) and highest concentrations of 0.19 mg/L (0.11 mg/L) and 3.4 mg/L, respectively. Both amines were present in blood in 8,496 cases at concentrations of 0.54 mg/L (0.35 mg/L) and 10.4 mg/L for AM and 0.41 mg/L (0.22 mg/L) and 5.6 mg/L for MA. However, the correlation between AM and MA was low and insignificant (r = -0.13) in the whole material. The coefficient of correlation increased to r = 0.41 (P < 0.001) when the MA/AM concentration ratio was >1. When MA/AM ratios were selected at intervals of 1.0 (e.g., >3.0 and <4.0 up to >9.0 and <10.0), the correlation between AM and MA was r = 0.99 (P < 0.001). Such cases represent the use of MA without contamination from AM, and the mean (median) and highest concentrations of this secondary amine in blood of DUID suspects were 0.72 mg/L (0.56 mg/L) and 4.2 mg/L, respectively.

Authors+Show Affiliations

Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden. wayne.jones@LIU.se

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23034928

Citation

Jones, A W., and A Holmgren. "Concentration Ratios of Methamphetamine to Amphetamine in Blood Can Help to Distinguish Use of Methamphetamine From Various Mixtures of the Two Stimulants." Journal of Analytical Toxicology, vol. 36, no. 9, 2012, pp. 634-7.
Jones AW, Holmgren A. Concentration ratios of methamphetamine to amphetamine in blood can help to distinguish use of methamphetamine from various mixtures of the two stimulants. J Anal Toxicol. 2012;36(9):634-7.
Jones, A. W., & Holmgren, A. (2012). Concentration ratios of methamphetamine to amphetamine in blood can help to distinguish use of methamphetamine from various mixtures of the two stimulants. Journal of Analytical Toxicology, 36(9), pp. 634-7. doi:10.1093/jat/bks075.
Jones AW, Holmgren A. Concentration Ratios of Methamphetamine to Amphetamine in Blood Can Help to Distinguish Use of Methamphetamine From Various Mixtures of the Two Stimulants. J Anal Toxicol. 2012;36(9):634-7. PubMed PMID: 23034928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concentration ratios of methamphetamine to amphetamine in blood can help to distinguish use of methamphetamine from various mixtures of the two stimulants. AU - Jones,A W, AU - Holmgren,A, Y1 - 2012/10/03/ PY - 2012/10/5/entrez PY - 2012/10/5/pubmed PY - 2013/3/27/medline SP - 634 EP - 7 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 36 IS - 9 N2 - Using a forensic toxicology database, the authors investigated cases of driving under the influence of drugs (DUID) if methamphetamine (MA) was identified in the blood samples (N = 9,310). The concentrations of MA and amphetamine (AM) in blood were determined after liquid-liquid extraction by gas chromatography-mass spectrometry at limits of quantitation of 0.03 mg/L for both stimulants. In 814 cases, AM was negative in blood and MA was positive at mean (median) and highest concentrations of 0.19 mg/L (0.11 mg/L) and 3.4 mg/L, respectively. Both amines were present in blood in 8,496 cases at concentrations of 0.54 mg/L (0.35 mg/L) and 10.4 mg/L for AM and 0.41 mg/L (0.22 mg/L) and 5.6 mg/L for MA. However, the correlation between AM and MA was low and insignificant (r = -0.13) in the whole material. The coefficient of correlation increased to r = 0.41 (P < 0.001) when the MA/AM concentration ratio was >1. When MA/AM ratios were selected at intervals of 1.0 (e.g., >3.0 and <4.0 up to >9.0 and <10.0), the correlation between AM and MA was r = 0.99 (P < 0.001). Such cases represent the use of MA without contamination from AM, and the mean (median) and highest concentrations of this secondary amine in blood of DUID suspects were 0.72 mg/L (0.56 mg/L) and 4.2 mg/L, respectively. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/23034928/Concentration_ratios_of_methamphetamine_to_amphetamine_in_blood_can_help_to_distinguish_use_of_methamphetamine_from_various_mixtures_of_the_two_stimulants_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bks075 DB - PRIME DP - Unbound Medicine ER -