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Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease.
Am J Clin Nutr 2012; 96(5):1113-8AJ

Abstract

BACKGROUND

Limited evidence from human and animal studies has suggested that vitamin K has a potentially beneficial role in glucose metabolism and insulin resistance.

OBJECTIVE

We analyzed the cross-sectional and longitudinal associations between dietary phylloquinone intake and type 2 diabetes in elderly subjects at high cardiovascular risk.

DESIGN

Cross-sectional associations were tested in 1925 men and women in the Prevention with the Mediterranean Diet trial. A longitudinal analysis was conducted on 1069 individuals free of diabetes at baseline (median follow-up: 5.5 y). Biochemical and anthropometric variables were obtained yearly. Dietary intake was collected during each annual visit by using a food-frequency questionnaire, and phylloquinone intake was estimated by using the USDA database. The occurrence of type 2 diabetes during follow-up was assessed by using American Diabetes Association criteria.

RESULTS

Dietary phylloquinone at baseline was significantly lower in subjects who developed type 2 diabetes during the study. After adjustment for potential confounders, risk of incident diabetes was 17% lower for each additional intake of 100 μg phylloquinone/d. Moreover, subjects who increased their dietary intake of vitamin K during the follow-up had a 51% reduced risk of incident diabetes compared with subjects who decreased or did not change the amount of phylloquinone intake.

CONCLUSION

We conclude that dietary phylloquinone intake is associated with reduced risk of type 2 diabetes. This trial was registered at http://www.controlled-trials.com as ISRCTN35739639.

Authors+Show Affiliations

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institute of Health Research Pere Virgli, Universitat Rovira i Virgili, Reus, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23034962

Citation

Ibarrola-Jurado, Núria, et al. "Dietary Phylloquinone Intake and Risk of Type 2 Diabetes in Elderly Subjects at High Risk of Cardiovascular Disease." The American Journal of Clinical Nutrition, vol. 96, no. 5, 2012, pp. 1113-8.
Ibarrola-Jurado N, Salas-Salvadó J, Martínez-González MA, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012;96(5):1113-8.
Ibarrola-Jurado, N., Salas-Salvadó, J., Martínez-González, M. A., & Bulló, M. (2012). Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. The American Journal of Clinical Nutrition, 96(5), pp. 1113-8. doi:10.3945/ajcn.111.033498.
Ibarrola-Jurado N, et al. Dietary Phylloquinone Intake and Risk of Type 2 Diabetes in Elderly Subjects at High Risk of Cardiovascular Disease. Am J Clin Nutr. 2012;96(5):1113-8. PubMed PMID: 23034962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. AU - Ibarrola-Jurado,Núria, AU - Salas-Salvadó,Jordi, AU - Martínez-González,Miguel A, AU - Bulló,Mònica, Y1 - 2012/10/03/ PY - 2012/10/5/entrez PY - 2012/10/5/pubmed PY - 2013/3/19/medline SP - 1113 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 5 N2 - BACKGROUND: Limited evidence from human and animal studies has suggested that vitamin K has a potentially beneficial role in glucose metabolism and insulin resistance. OBJECTIVE: We analyzed the cross-sectional and longitudinal associations between dietary phylloquinone intake and type 2 diabetes in elderly subjects at high cardiovascular risk. DESIGN: Cross-sectional associations were tested in 1925 men and women in the Prevention with the Mediterranean Diet trial. A longitudinal analysis was conducted on 1069 individuals free of diabetes at baseline (median follow-up: 5.5 y). Biochemical and anthropometric variables were obtained yearly. Dietary intake was collected during each annual visit by using a food-frequency questionnaire, and phylloquinone intake was estimated by using the USDA database. The occurrence of type 2 diabetes during follow-up was assessed by using American Diabetes Association criteria. RESULTS: Dietary phylloquinone at baseline was significantly lower in subjects who developed type 2 diabetes during the study. After adjustment for potential confounders, risk of incident diabetes was 17% lower for each additional intake of 100 μg phylloquinone/d. Moreover, subjects who increased their dietary intake of vitamin K during the follow-up had a 51% reduced risk of incident diabetes compared with subjects who decreased or did not change the amount of phylloquinone intake. CONCLUSION: We conclude that dietary phylloquinone intake is associated with reduced risk of type 2 diabetes. This trial was registered at http://www.controlled-trials.com as ISRCTN35739639. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23034962/Dietary_phylloquinone_intake_and_risk_of_type_2_diabetes_in_elderly_subjects_at_high_risk_of_cardiovascular_disease_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.033498 DB - PRIME DP - Unbound Medicine ER -