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Pseudoexfoliation syndrome and the long-term incidence of cataract and cataract surgery: the blue mountains eye study.
Am J Ophthalmol. 2013 Jan; 155(1):83-88.e1.AJ

Abstract

PURPOSE

To assess whether the pseudoexfoliation syndrome (PXS) is associated with the long-term incidence of cataract or cataract surgery.

DESIGN

Population-based cohort study.

METHODS

The Blue Mountains Eye Study examined 3654 persons 49 years of age and older at baseline; 2564 were re-examined after 5 or 10 years, or both. PXS was recorded at the baseline eye examination by an ophthalmologist. Masked graders assessed lens photographs using the Wisconsin Cataract Grading System. Generalized estimating equation regression models were used to examine the association between PXS and cataract by eye.

RESULTS

Eyes with PXS had a significantly greater prevalence of cortical cataract (P=.02) and nuclear cataract (P < .0001) than eyes without PXS. The association between PXS and cortical cataract, however, did not persist after further adjustment for age, gender, smoking, diabetes, steroid use, myopia, socioeconomic status, and open-angle glaucoma (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.53 to 1.46), whereas the association between PXS and nuclear cataract persisted after adjustment for the above confounders (OR, 1.90; 95% CI, 1.04 to 3.48). In addition, significant associations were found between the presence of PXS at baseline and the 10-year incidence of either nuclear cataract (P < .0001) or cataract surgery (P < .0001). These associations persisted after adjustment for the potential confounders listed above (OR, 3.25; 95% CI, 1.38 to 7.65; and OR, 4.09; 95% CI, 2.25 to 7.44; respectively). No significant cross-sectional or longitudinal associations were found between PXS and posterior subcapsular cataract.

CONCLUSIONS

Long-term follow-up data from this population-based older cohort suggest that the presence of PXS is associated with an increased risk of nuclear cataract and cataract surgery.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23036566

Citation

Kanthan, Gowri L., et al. "Pseudoexfoliation Syndrome and the Long-term Incidence of Cataract and Cataract Surgery: the Blue Mountains Eye Study." American Journal of Ophthalmology, vol. 155, no. 1, 2013, pp. 83-88.e1.
Kanthan GL, Mitchell P, Burlutsky G, et al. Pseudoexfoliation syndrome and the long-term incidence of cataract and cataract surgery: the blue mountains eye study. Am J Ophthalmol. 2013;155(1):83-88.e1.
Kanthan, G. L., Mitchell, P., Burlutsky, G., Rochtchina, E., & Wang, J. J. (2013). Pseudoexfoliation syndrome and the long-term incidence of cataract and cataract surgery: the blue mountains eye study. American Journal of Ophthalmology, 155(1), 83-e1. https://doi.org/10.1016/j.ajo.2012.07.002
Kanthan GL, et al. Pseudoexfoliation Syndrome and the Long-term Incidence of Cataract and Cataract Surgery: the Blue Mountains Eye Study. Am J Ophthalmol. 2013;155(1):83-88.e1. PubMed PMID: 23036566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pseudoexfoliation syndrome and the long-term incidence of cataract and cataract surgery: the blue mountains eye study. AU - Kanthan,Gowri L, AU - Mitchell,Paul, AU - Burlutsky,George, AU - Rochtchina,Elena, AU - Wang,Jie Jin, Y1 - 2012/10/02/ PY - 2011/10/23/received PY - 2012/07/08/revised PY - 2012/07/10/accepted PY - 2012/10/6/entrez PY - 2012/10/6/pubmed PY - 2013/2/22/medline SP - 83 EP - 88.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 155 IS - 1 N2 - PURPOSE: To assess whether the pseudoexfoliation syndrome (PXS) is associated with the long-term incidence of cataract or cataract surgery. DESIGN: Population-based cohort study. METHODS: The Blue Mountains Eye Study examined 3654 persons 49 years of age and older at baseline; 2564 were re-examined after 5 or 10 years, or both. PXS was recorded at the baseline eye examination by an ophthalmologist. Masked graders assessed lens photographs using the Wisconsin Cataract Grading System. Generalized estimating equation regression models were used to examine the association between PXS and cataract by eye. RESULTS: Eyes with PXS had a significantly greater prevalence of cortical cataract (P=.02) and nuclear cataract (P < .0001) than eyes without PXS. The association between PXS and cortical cataract, however, did not persist after further adjustment for age, gender, smoking, diabetes, steroid use, myopia, socioeconomic status, and open-angle glaucoma (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.53 to 1.46), whereas the association between PXS and nuclear cataract persisted after adjustment for the above confounders (OR, 1.90; 95% CI, 1.04 to 3.48). In addition, significant associations were found between the presence of PXS at baseline and the 10-year incidence of either nuclear cataract (P < .0001) or cataract surgery (P < .0001). These associations persisted after adjustment for the potential confounders listed above (OR, 3.25; 95% CI, 1.38 to 7.65; and OR, 4.09; 95% CI, 2.25 to 7.44; respectively). No significant cross-sectional or longitudinal associations were found between PXS and posterior subcapsular cataract. CONCLUSIONS: Long-term follow-up data from this population-based older cohort suggest that the presence of PXS is associated with an increased risk of nuclear cataract and cataract surgery. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/23036566/Pseudoexfoliation_syndrome_and_the_long_term_incidence_of_cataract_and_cataract_surgery:_the_blue_mountains_eye_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(12)00498-9 DB - PRIME DP - Unbound Medicine ER -