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The use of a combination of different MR methods to study swelling of hydrophilic xanthan matrix tablets at different pHs.
Prilozi. 2012; 33(1):391-5.P

Abstract

Modified-release matrix tablets have been extensively used by the pharmaceutical industry as one of the most successful oral drug-delivery systems. The key element in drug release from hydrophilic matrix tablets is the gel layer that regulates the penetration of water and controls drug dissolution and diffusion. Magnetic resonance imaging (MRI) is a powerful, non-invasive technique that can help improve our understanding of the gel layer formed on swellable, polymer-matrix tablets, as well as the layer's properties and its influence on the drug release. The aim was to investigate the effects of pH and ionic strength on swelling and to study the influence of structural changes in xanthan gel on drug release. For this purpose a combination of different MRI methods for accurate determination of penetration, swelling and erosion fronts was used. The position of the penetration and swelling fronts were the same, independently of the different xanthan gel structures formed under different conditions of pH and ionic strength. The position of the erosion front, on the other hand, is strongly dependent on pH and ionic strength, as reflected in different thicknesses of the gel layers.

Authors+Show Affiliations

Mikac U
Jozef Stefan Institute, Ljubljana, Slovenia.
Sepe A
No affiliation info available
Kristl J
No affiliation info available
Baumgartner I
No affiliation info available

MeSH

Drug CarriersHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsMagnetic Resonance ImagingPolysaccharides, BacterialTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23037184

Citation

Mikac, U, et al. "The Use of a Combination of Different MR Methods to Study Swelling of Hydrophilic Xanthan Matrix Tablets at Different PHs." Prilozi, vol. 33, no. 1, 2012, pp. 391-5.
Mikac U, Sepe A, Kristl J, et al. The use of a combination of different MR methods to study swelling of hydrophilic xanthan matrix tablets at different pHs. Prilozi. 2012;33(1):391-5.
Mikac, U., Sepe, A., Kristl, J., & Baumgartner, I. (2012). The use of a combination of different MR methods to study swelling of hydrophilic xanthan matrix tablets at different pHs. Prilozi, 33(1), 391-5.
Mikac U, et al. The Use of a Combination of Different MR Methods to Study Swelling of Hydrophilic Xanthan Matrix Tablets at Different PHs. Prilozi. 2012;33(1):391-5. PubMed PMID: 23037184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of a combination of different MR methods to study swelling of hydrophilic xanthan matrix tablets at different pHs. AU - Mikac,U, AU - Sepe,A, AU - Kristl,J, AU - Baumgartner,I, PY - 2012/10/6/entrez PY - 2012/10/6/pubmed PY - 2016/4/9/medline SP - 391 EP - 5 JF - Prilozi JO - Prilozi VL - 33 IS - 1 N2 - Modified-release matrix tablets have been extensively used by the pharmaceutical industry as one of the most successful oral drug-delivery systems. The key element in drug release from hydrophilic matrix tablets is the gel layer that regulates the penetration of water and controls drug dissolution and diffusion. Magnetic resonance imaging (MRI) is a powerful, non-invasive technique that can help improve our understanding of the gel layer formed on swellable, polymer-matrix tablets, as well as the layer's properties and its influence on the drug release. The aim was to investigate the effects of pH and ionic strength on swelling and to study the influence of structural changes in xanthan gel on drug release. For this purpose a combination of different MRI methods for accurate determination of penetration, swelling and erosion fronts was used. The position of the penetration and swelling fronts were the same, independently of the different xanthan gel structures formed under different conditions of pH and ionic strength. The position of the erosion front, on the other hand, is strongly dependent on pH and ionic strength, as reflected in different thicknesses of the gel layers. SN - 0351-3254 UR - https://www.unboundmedicine.com/medline/citation/23037184/The_use_of_a_combination_of_different_MR_methods_to_study_swelling_of_hydrophilic_xanthan_matrix_tablets_at_different_pHs_ L2 - https://medlineplus.gov/mriscans.html DB - PRIME DP - Unbound Medicine ER -