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Vitamin D in multiple sclerosis: implications for assessment and treatment.
Expert Rev Neurother 2012; 12(9):1101-12ER

Abstract

Epidemiological and experimental evidence suggest that a poor vitamin D status is associated with an increased risk of developing multiple sclerosis (MS), and also an unfavorable disease course. Vitamin D may exert relevant effects both on the immune system and on resident cells within the CNS. The data from clinical trials is, however, restricted, and does not allow any conclusion on the effect of high-dose vitamin D supplementation on disease course. The results from sufficiently powered studies will not be available for at least 2 years. MS patients are, however, prone to develop osteoporosis and have increased risk of fractures. Therefore, the authors advise that the serum concentration of 25-hydroxyvitamin D is monitored in order to prevent bone deficit, and that a serum level of 75-125 nmol/l is targeted. This level is sufficient for maintenance of bone health, is not known to be associated with adverse events, and is in the range that has been associated with low risk of developing MS and low disease activity.

Authors+Show Affiliations

Department of Neurology, Akershus University Hospital, Lørenskog, Norway. trygve.holmoy@medisin.uio.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23039389

Citation

Holmøy, Trygve, et al. "Vitamin D in Multiple Sclerosis: Implications for Assessment and Treatment." Expert Review of Neurotherapeutics, vol. 12, no. 9, 2012, pp. 1101-12.
Holmøy T, Kampman MT, Smolders J. Vitamin D in multiple sclerosis: implications for assessment and treatment. Expert Rev Neurother. 2012;12(9):1101-12.
Holmøy, T., Kampman, M. T., & Smolders, J. (2012). Vitamin D in multiple sclerosis: implications for assessment and treatment. Expert Review of Neurotherapeutics, 12(9), pp. 1101-12. doi:10.1586/ern.12.99.
Holmøy T, Kampman MT, Smolders J. Vitamin D in Multiple Sclerosis: Implications for Assessment and Treatment. Expert Rev Neurother. 2012;12(9):1101-12. PubMed PMID: 23039389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in multiple sclerosis: implications for assessment and treatment. AU - Holmøy,Trygve, AU - Kampman,Margitta T, AU - Smolders,Joost, PY - 2012/10/9/entrez PY - 2012/10/9/pubmed PY - 2013/2/28/medline SP - 1101 EP - 12 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 12 IS - 9 N2 - Epidemiological and experimental evidence suggest that a poor vitamin D status is associated with an increased risk of developing multiple sclerosis (MS), and also an unfavorable disease course. Vitamin D may exert relevant effects both on the immune system and on resident cells within the CNS. The data from clinical trials is, however, restricted, and does not allow any conclusion on the effect of high-dose vitamin D supplementation on disease course. The results from sufficiently powered studies will not be available for at least 2 years. MS patients are, however, prone to develop osteoporosis and have increased risk of fractures. Therefore, the authors advise that the serum concentration of 25-hydroxyvitamin D is monitored in order to prevent bone deficit, and that a serum level of 75-125 nmol/l is targeted. This level is sufficient for maintenance of bone health, is not known to be associated with adverse events, and is in the range that has been associated with low risk of developing MS and low disease activity. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/23039389/Vitamin_D_in_multiple_sclerosis:_implications_for_assessment_and_treatment_ L2 - http://www.tandfonline.com/doi/full/10.1586/ern.12.99 DB - PRIME DP - Unbound Medicine ER -