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Anatomical and functional damage in experimental glaucoma.
Curr Opin Pharmacol. 2013 Feb; 13(1):5-11.CO

Abstract

Glaucoma is a progressive neurodegenerative disease caused by retinal ganglion cell (RGC) loss. One important risk factor for glaucoma is elevated intraocular pressure and thus many animal models are based on spontaneous or induced ocular hypertension (OHT). Using these models it has been shown that RGCs initially suffer an impairment of the active axonal transport that progresses to a lack of passive diffusion along the axon. This axonal damage eventually causes the death of the parent RGCs in pie-shaped sectors of the retina, but there is also diffuse RGC loss, without involving displaced amacrine cells. Recent data show that OHT results in a protracted insult to the inner and outer retina that causes functional alterations and ultimately, degeneration and death of cones.

Authors+Show Affiliations

Departamento de Oftalmología, Regional Campus of International Excellence Campus Mare Nostrum, IMIB, Universidad de Murcia, Murcia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23041078

Citation

Agudo-Barriuso, M, et al. "Anatomical and Functional Damage in Experimental Glaucoma." Current Opinion in Pharmacology, vol. 13, no. 1, 2013, pp. 5-11.
Agudo-Barriuso M, Villegas-Pérez MP, de Imperial JM, et al. Anatomical and functional damage in experimental glaucoma. Curr Opin Pharmacol. 2013;13(1):5-11.
Agudo-Barriuso, M., Villegas-Pérez, M. P., de Imperial, J. M., & Vidal-Sanz, M. (2013). Anatomical and functional damage in experimental glaucoma. Current Opinion in Pharmacology, 13(1), 5-11. https://doi.org/10.1016/j.coph.2012.09.006
Agudo-Barriuso M, et al. Anatomical and Functional Damage in Experimental Glaucoma. Curr Opin Pharmacol. 2013;13(1):5-11. PubMed PMID: 23041078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anatomical and functional damage in experimental glaucoma. AU - Agudo-Barriuso,M, AU - Villegas-Pérez,M P, AU - de Imperial,J Miralles, AU - Vidal-Sanz,M, Y1 - 2012/10/04/ PY - 2012/08/14/received PY - 2012/09/12/revised PY - 2012/09/16/accepted PY - 2012/10/9/entrez PY - 2012/10/9/pubmed PY - 2013/5/29/medline SP - 5 EP - 11 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 13 IS - 1 N2 - Glaucoma is a progressive neurodegenerative disease caused by retinal ganglion cell (RGC) loss. One important risk factor for glaucoma is elevated intraocular pressure and thus many animal models are based on spontaneous or induced ocular hypertension (OHT). Using these models it has been shown that RGCs initially suffer an impairment of the active axonal transport that progresses to a lack of passive diffusion along the axon. This axonal damage eventually causes the death of the parent RGCs in pie-shaped sectors of the retina, but there is also diffuse RGC loss, without involving displaced amacrine cells. Recent data show that OHT results in a protracted insult to the inner and outer retina that causes functional alterations and ultimately, degeneration and death of cones. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/23041078/Anatomical_and_functional_damage_in_experimental_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(12)00163-4 DB - PRIME DP - Unbound Medicine ER -