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Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles.
Org Biomol Chem. 2012 Nov 28; 10(44):8808-13.OB

Abstract

The 3,3'-bioxindole derivatives were constructed in a single step via an efficient Rh(2)(OAc)(4) catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3'-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).

Authors+Show Affiliations

Shanghai Engineering Research Centre of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23042091

Citation

Li, Ming, et al. "Rhodium(II) Catalyzed Diastereoselective Reactions of Diazoacetamides With Isatins: an Efficient Approach to 3-hydroxy-3,3'-bioxindoles." Organic & Biomolecular Chemistry, vol. 10, no. 44, 2012, pp. 8808-13.
Li M, Zan L, Prajapati D, et al. Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles. Org Biomol Chem. 2012;10(44):8808-13.
Li, M., Zan, L., Prajapati, D., & Hu, W. (2012). Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles. Organic & Biomolecular Chemistry, 10(44), 8808-13. https://doi.org/10.1039/c2ob26580j
Li M, et al. Rhodium(II) Catalyzed Diastereoselective Reactions of Diazoacetamides With Isatins: an Efficient Approach to 3-hydroxy-3,3'-bioxindoles. Org Biomol Chem. 2012 Nov 28;10(44):8808-13. PubMed PMID: 23042091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles. AU - Li,Ming, AU - Zan,Li, AU - Prajapati,Dipak, AU - Hu,Wenhao, PY - 2012/10/9/entrez PY - 2012/10/9/pubmed PY - 2013/3/23/medline SP - 8808 EP - 13 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 10 IS - 44 N2 - The 3,3'-bioxindole derivatives were constructed in a single step via an efficient Rh(2)(OAc)(4) catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3'-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5). SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/23042091/Rhodium_II__catalyzed_diastereoselective_reactions_of_diazoacetamides_with_isatins:_an_efficient_approach_to_3_hydroxy_33'_bioxindoles_ L2 - https://doi.org/10.1039/c2ob26580j DB - PRIME DP - Unbound Medicine ER -