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Relationship of cognitive function with B vitamin status, homocysteine, and tissue factor pathway inhibitor in cognitively impaired elderly: a cross-sectional survey.
J Alzheimers Dis 2013; 33(3):853-62JA

Abstract

Elevated homocysteine (Hcy) levels have been associated with an increased risk of cognitive impairment and Alzheimer's disease (AD). Tissue factor pathway inhibitor (TFPI) has recently emerged as a candidate marker of endothelial damage in AD. We investigated the relationship between plasma levels of folate, vitamin B12, Hcy, and TFPI, as well as cognitive function in 321 [100 each with mild cognitive impairment (MCI) and AD, 121 normal subjects] Korean elderly (mean age 74.8 ± 7.2 years). Plasma folate and vitamin B12 concentrations were analyzed by radioimmunoassay, Hcy by the HPLC-fluorescence method, and TFPI by enzyme-linked immunosorbent assay. Plasma Hcy levels were higher in patients with AD and MCI than those in normal subjects (p < 0.001). The AD group had higher proportions of hyperhomocysteinemic (>15 μM) and folate deficient (<3.0 ng/mL) (p = 0.026) subjects. A multiple regression analysis after adjusting for covariates revealed positive relationships between plasma folate and the MMSE-KC and Boston Naming Test, and between plasma vitamin B12 and the Word List Memory Test in the AD group, but negative associations between plasma Hcy and the Word List Memory and Constructional Recall Tests and between plasma TFPI and the Boston Naming, Word List Recall, and Constructional Recall Tests. In contrast, only plasma folate level was positively associated with the MMSE-KC and Boston Naming Test in the MCI group. No associations were observed in the normal group. These results suggest that plasma folate, vitamin B12, Hcy, and TFPI are associated with cognitive function in cognitively impaired (AD and MCI) elderly and that the association was stronger in patients with AD.

Authors+Show Affiliations

Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23042212

Citation

Kim, Ggotpin, et al. "Relationship of Cognitive Function With B Vitamin Status, Homocysteine, and Tissue Factor Pathway Inhibitor in Cognitively Impaired Elderly: a Cross-sectional Survey." Journal of Alzheimer's Disease : JAD, vol. 33, no. 3, 2013, pp. 853-62.
Kim G, Kim H, Kim KN, et al. Relationship of cognitive function with B vitamin status, homocysteine, and tissue factor pathway inhibitor in cognitively impaired elderly: a cross-sectional survey. J Alzheimers Dis. 2013;33(3):853-62.
Kim, G., Kim, H., Kim, K. N., Son, J. I., Kim, S. Y., Tamura, T., & Chang, N. (2013). Relationship of cognitive function with B vitamin status, homocysteine, and tissue factor pathway inhibitor in cognitively impaired elderly: a cross-sectional survey. Journal of Alzheimer's Disease : JAD, 33(3), pp. 853-62. doi:10.3233/JAD-2012-121345.
Kim G, et al. Relationship of Cognitive Function With B Vitamin Status, Homocysteine, and Tissue Factor Pathway Inhibitor in Cognitively Impaired Elderly: a Cross-sectional Survey. J Alzheimers Dis. 2013;33(3):853-62. PubMed PMID: 23042212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of cognitive function with B vitamin status, homocysteine, and tissue factor pathway inhibitor in cognitively impaired elderly: a cross-sectional survey. AU - Kim,Ggotpin, AU - Kim,Hyesook, AU - Kim,Ki Nam, AU - Son,Jung In, AU - Kim,Seong Yoon, AU - Tamura,Tsunenobu, AU - Chang,Namsoo, PY - 2012/10/9/entrez PY - 2012/10/9/pubmed PY - 2013/6/26/medline SP - 853 EP - 62 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 33 IS - 3 N2 - Elevated homocysteine (Hcy) levels have been associated with an increased risk of cognitive impairment and Alzheimer's disease (AD). Tissue factor pathway inhibitor (TFPI) has recently emerged as a candidate marker of endothelial damage in AD. We investigated the relationship between plasma levels of folate, vitamin B12, Hcy, and TFPI, as well as cognitive function in 321 [100 each with mild cognitive impairment (MCI) and AD, 121 normal subjects] Korean elderly (mean age 74.8 ± 7.2 years). Plasma folate and vitamin B12 concentrations were analyzed by radioimmunoassay, Hcy by the HPLC-fluorescence method, and TFPI by enzyme-linked immunosorbent assay. Plasma Hcy levels were higher in patients with AD and MCI than those in normal subjects (p < 0.001). The AD group had higher proportions of hyperhomocysteinemic (>15 μM) and folate deficient (<3.0 ng/mL) (p = 0.026) subjects. A multiple regression analysis after adjusting for covariates revealed positive relationships between plasma folate and the MMSE-KC and Boston Naming Test, and between plasma vitamin B12 and the Word List Memory Test in the AD group, but negative associations between plasma Hcy and the Word List Memory and Constructional Recall Tests and between plasma TFPI and the Boston Naming, Word List Recall, and Constructional Recall Tests. In contrast, only plasma folate level was positively associated with the MMSE-KC and Boston Naming Test in the MCI group. No associations were observed in the normal group. These results suggest that plasma folate, vitamin B12, Hcy, and TFPI are associated with cognitive function in cognitively impaired (AD and MCI) elderly and that the association was stronger in patients with AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/23042212/Relationship_of_cognitive_function_with_B_vitamin_status_homocysteine_and_tissue_factor_pathway_inhibitor_in_cognitively_impaired_elderly:_a_cross_sectional_survey_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-2012-121345 DB - PRIME DP - Unbound Medicine ER -