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The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies.
JAMA 1990; 263(9):1218-22JAMA

Abstract

To determine trends in the incidence and epidemiology of acute hepatitis B in the United States we conducted intensive surveillance for viral hepatitis in four sentinel counties from October 1, 1981, to September 30, 1988. The overall incidence of hepatitis B remained relatively constant throughout the study period (average, 13.2 cases per 100,000 population), but disease transmission patterns changed significantly. The proportions of hepatitis B cases accounted for by homosexual activity and health care employment decreased 62% and 75%, respectively; the proportions of cases accounted for by parenteral drug use and heterosexual exposure increased 80% and 38%, respectively. The percentage of patients for whom no risk factor was identified (30% to 40%) did not change over time. These patients tended to belong to minority populations, and their socioeconomic level was low. The decline in the number of hepatitis B cases among homosexual men probably results from the modification of high-risk sexual behavior; the decline among health care workers is due mostly to hepatitis B immunization. The current strategy for prevention of hepatitis B, which targets high-risk groups for immunization, has failed to have a significant impact on the incidence of disease.

Authors+Show Affiliations

Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, Ga 30333.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2304237

Citation

Alter, M J., et al. "The Changing Epidemiology of Hepatitis B in the United States. Need for Alternative Vaccination Strategies." JAMA, vol. 263, no. 9, 1990, pp. 1218-22.
Alter MJ, Hadler SC, Margolis HS, et al. The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies. JAMA. 1990;263(9):1218-22.
Alter, M. J., Hadler, S. C., Margolis, H. S., Alexander, W. J., Hu, P. Y., Judson, F. N., ... Moyer, L. A. (1990). The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies. JAMA, 263(9), pp. 1218-22.
Alter MJ, et al. The Changing Epidemiology of Hepatitis B in the United States. Need for Alternative Vaccination Strategies. JAMA. 1990 Mar 2;263(9):1218-22. PubMed PMID: 2304237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies. AU - Alter,M J, AU - Hadler,S C, AU - Margolis,H S, AU - Alexander,W J, AU - Hu,P Y, AU - Judson,F N, AU - Mares,A, AU - Miller,J K, AU - Moyer,L A, PY - 1990/3/2/pubmed PY - 1990/3/2/medline PY - 1990/3/2/entrez SP - 1218 EP - 22 JF - JAMA JO - JAMA VL - 263 IS - 9 N2 - To determine trends in the incidence and epidemiology of acute hepatitis B in the United States we conducted intensive surveillance for viral hepatitis in four sentinel counties from October 1, 1981, to September 30, 1988. The overall incidence of hepatitis B remained relatively constant throughout the study period (average, 13.2 cases per 100,000 population), but disease transmission patterns changed significantly. The proportions of hepatitis B cases accounted for by homosexual activity and health care employment decreased 62% and 75%, respectively; the proportions of cases accounted for by parenteral drug use and heterosexual exposure increased 80% and 38%, respectively. The percentage of patients for whom no risk factor was identified (30% to 40%) did not change over time. These patients tended to belong to minority populations, and their socioeconomic level was low. The decline in the number of hepatitis B cases among homosexual men probably results from the modification of high-risk sexual behavior; the decline among health care workers is due mostly to hepatitis B immunization. The current strategy for prevention of hepatitis B, which targets high-risk groups for immunization, has failed to have a significant impact on the incidence of disease. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/2304237/full_citation L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/263/pg/1218 DB - PRIME DP - Unbound Medicine ER -