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Anthropometric measures of visceral and subcutaneous fat are important in the determination of metabolic dysregulation in boys and girls at risk for nonalcoholic fatty liver disease.
Nutr Clin Pract. 2013 Feb; 28(1):101-11.NC

Abstract

BACKGROUND

Nonalcoholic fatty liver disease (NAFLD) is increasing at alarming rates in obese children. The study aim was to describe body composition/somatotype and its interrelationships to biomarkers of liver disease, insulin resistance, and lipid and cytokine expression in youth with NAFLD.

METHODS

Somatotype and body composition of children (7-18 years) diagnosed with NAFLD (n= 18) were compared with obese (n = 11) and lean children (n = 17). Anthropometric variables assessed included weight, height, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and multiple skinfold thicknesses. Fat mass (FM) and somatotype analysis were measured using validated methodologies. Fasting liver biochemistries (aspartate aminotransferase [AST], alanine aminotransferase [ALT], γ-glutamyltransferase [GGT]), insulin, glucose, leptin, C-reactive protein (CRP), tumor necrosis factor-α, interleukin (IL) factors 6/10, apolipoproteins B-100/B-48 and C-III, triglycerides, and high-density lipoprotein (HDL)/low-density lipoprotein (LDL) cholesterol were measured. Insulin resistance was assessed by the homeostasis model of insulin resistance (HOMA-IR).

RESULTS

BMI z score, WC, FM, and somatotype did not differ between NAFLD and obese groups; however, lean children were lighter/leaner across all anthropometric measures (P < .001). Children with NAFLD had a higher sum-of-trunk to sum-of-extremity ratio (1.6 ± 0.4) than did obese (1.3 ± 0.2) and lean (1.1 ± 0.5) children (P < .001). Markers of central visceral (WC/WHTR) and subcutaneous fat (subscapular, abdominal, suprailiac skinfolds) were associated with elevated plasma concentrations of insulin, HOMA-IR, ALT, GGT, and AST and lower HDL cholesterol and IL-10 (P < .001).

CONCLUSION

Comprehensive assessment of body composition, including measurement of surrogate markers of subcutaneous and visceral fat, provides information regarding metabolic dysregulation and liver disease risk in obese children with NAFLD.

Authors+Show Affiliations

Department of Agriculture, Food and Nutritional Science, Department of Pediatrics,University of Alberta, 4-126 Li Ka Shing Centre for Research Innovation,Edmonton, AB T6G OK2, Canada. mager@ualberta.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23042833

Citation

Mager, Diana R., et al. "Anthropometric Measures of Visceral and Subcutaneous Fat Are Important in the Determination of Metabolic Dysregulation in Boys and Girls at Risk for Nonalcoholic Fatty Liver Disease." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 28, no. 1, 2013, pp. 101-11.
Mager DR, Yap J, Rodriguez-Dimitrescu C, et al. Anthropometric measures of visceral and subcutaneous fat are important in the determination of metabolic dysregulation in boys and girls at risk for nonalcoholic fatty liver disease. Nutr Clin Pract. 2013;28(1):101-11.
Mager, D. R., Yap, J., Rodriguez-Dimitrescu, C., Mazurak, V., Ball, G., & Gilmour, S. (2013). Anthropometric measures of visceral and subcutaneous fat are important in the determination of metabolic dysregulation in boys and girls at risk for nonalcoholic fatty liver disease. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 28(1), 101-11. https://doi.org/10.1177/0884533612454884
Mager DR, et al. Anthropometric Measures of Visceral and Subcutaneous Fat Are Important in the Determination of Metabolic Dysregulation in Boys and Girls at Risk for Nonalcoholic Fatty Liver Disease. Nutr Clin Pract. 2013;28(1):101-11. PubMed PMID: 23042833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric measures of visceral and subcutaneous fat are important in the determination of metabolic dysregulation in boys and girls at risk for nonalcoholic fatty liver disease. AU - Mager,Diana R, AU - Yap,Jason, AU - Rodriguez-Dimitrescu,Carla, AU - Mazurak,Vera, AU - Ball,Geoff, AU - Gilmour,Susan, Y1 - 2012/10/05/ PY - 2012/10/9/entrez PY - 2012/10/9/pubmed PY - 2013/7/3/medline SP - 101 EP - 11 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 28 IS - 1 N2 - BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is increasing at alarming rates in obese children. The study aim was to describe body composition/somatotype and its interrelationships to biomarkers of liver disease, insulin resistance, and lipid and cytokine expression in youth with NAFLD. METHODS: Somatotype and body composition of children (7-18 years) diagnosed with NAFLD (n= 18) were compared with obese (n = 11) and lean children (n = 17). Anthropometric variables assessed included weight, height, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and multiple skinfold thicknesses. Fat mass (FM) and somatotype analysis were measured using validated methodologies. Fasting liver biochemistries (aspartate aminotransferase [AST], alanine aminotransferase [ALT], γ-glutamyltransferase [GGT]), insulin, glucose, leptin, C-reactive protein (CRP), tumor necrosis factor-α, interleukin (IL) factors 6/10, apolipoproteins B-100/B-48 and C-III, triglycerides, and high-density lipoprotein (HDL)/low-density lipoprotein (LDL) cholesterol were measured. Insulin resistance was assessed by the homeostasis model of insulin resistance (HOMA-IR). RESULTS: BMI z score, WC, FM, and somatotype did not differ between NAFLD and obese groups; however, lean children were lighter/leaner across all anthropometric measures (P < .001). Children with NAFLD had a higher sum-of-trunk to sum-of-extremity ratio (1.6 ± 0.4) than did obese (1.3 ± 0.2) and lean (1.1 ± 0.5) children (P < .001). Markers of central visceral (WC/WHTR) and subcutaneous fat (subscapular, abdominal, suprailiac skinfolds) were associated with elevated plasma concentrations of insulin, HOMA-IR, ALT, GGT, and AST and lower HDL cholesterol and IL-10 (P < .001). CONCLUSION: Comprehensive assessment of body composition, including measurement of surrogate markers of subcutaneous and visceral fat, provides information regarding metabolic dysregulation and liver disease risk in obese children with NAFLD. SN - 1941-2452 UR - https://www.unboundmedicine.com/medline/citation/23042833/Anthropometric_measures_of_visceral_and_subcutaneous_fat_are_important_in_the_determination_of_metabolic_dysregulation_in_boys_and_girls_at_risk_for_nonalcoholic_fatty_liver_disease_ L2 - https://doi.org/10.1177/0884533612454884 DB - PRIME DP - Unbound Medicine ER -