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Selenium and the thyroid gland: more good news for clinicians.
Clin Endocrinol (Oxf) 2013; 78(2):155-64CE

Abstract

The thyroid is the organ with the highest selenium content per gram of tissue because it expresses specific selenoproteins. Since the discovery of myxoedematous cretinism and thyroid destruction following selenium repletion in iodine- and selenium-deficient children, data on links between thyroid metabolism and selenium have multiplied. Although very minor amounts of selenium appear sufficient for adequate activity of deiodinases, thus limiting the impact of its potential deficiency on synthesis of thyroid hormones, selenium status appears to have an impact on the development of thyroid pathologies. The value of selenium supplementation in autoimmune thyroid disorders has been emphasized. Most authors attribute the effect of supplementation on the immune system to the regulation of the production of reactive oxygen species and their metabolites. In patients with Hashimoto's disease and in pregnant women with anti-TPO antibodies, selenium supplementation decreases anti-thyroid antibody levels and improves the ultrasound structure of the thyroid gland. Although clinical applications still need to be defined for Hashimoto's disease, they are very interesting for pregnant women given that supplementation significantly decreases the percentage of postpartum thyroiditis and definitive hypothyroidism. In Graves' disease, selenium supplementation results in euthyroidism being achieved more rapidly and appears to have a beneficial effect on mild inflammatory orbitopathy. A risk of diabetes has been reported following long-term selenium supplementation, but few data are available on the side effects associated with such supplementation and further studies are required.

Authors+Show Affiliations

Department of Endocrinology and Metabolic diseases, Hôpital du Cluzeau, Limoges Cedex, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23046013

Citation

Drutel, Anne, et al. "Selenium and the Thyroid Gland: More Good News for Clinicians." Clinical Endocrinology, vol. 78, no. 2, 2013, pp. 155-64.
Drutel A, Archambeaud F, Caron P. Selenium and the thyroid gland: more good news for clinicians. Clin Endocrinol (Oxf). 2013;78(2):155-64.
Drutel, A., Archambeaud, F., & Caron, P. (2013). Selenium and the thyroid gland: more good news for clinicians. Clinical Endocrinology, 78(2), pp. 155-64. doi:10.1111/cen.12066.
Drutel A, Archambeaud F, Caron P. Selenium and the Thyroid Gland: More Good News for Clinicians. Clin Endocrinol (Oxf). 2013;78(2):155-64. PubMed PMID: 23046013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and the thyroid gland: more good news for clinicians. AU - Drutel,Anne, AU - Archambeaud,Françoise, AU - Caron,Philippe, PY - 2012/08/15/received PY - 2012/08/23/revised PY - 2012/09/17/revised PY - 2012/10/03/accepted PY - 2012/10/11/entrez PY - 2012/10/11/pubmed PY - 2013/6/7/medline SP - 155 EP - 64 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 78 IS - 2 N2 - The thyroid is the organ with the highest selenium content per gram of tissue because it expresses specific selenoproteins. Since the discovery of myxoedematous cretinism and thyroid destruction following selenium repletion in iodine- and selenium-deficient children, data on links between thyroid metabolism and selenium have multiplied. Although very minor amounts of selenium appear sufficient for adequate activity of deiodinases, thus limiting the impact of its potential deficiency on synthesis of thyroid hormones, selenium status appears to have an impact on the development of thyroid pathologies. The value of selenium supplementation in autoimmune thyroid disorders has been emphasized. Most authors attribute the effect of supplementation on the immune system to the regulation of the production of reactive oxygen species and their metabolites. In patients with Hashimoto's disease and in pregnant women with anti-TPO antibodies, selenium supplementation decreases anti-thyroid antibody levels and improves the ultrasound structure of the thyroid gland. Although clinical applications still need to be defined for Hashimoto's disease, they are very interesting for pregnant women given that supplementation significantly decreases the percentage of postpartum thyroiditis and definitive hypothyroidism. In Graves' disease, selenium supplementation results in euthyroidism being achieved more rapidly and appears to have a beneficial effect on mild inflammatory orbitopathy. A risk of diabetes has been reported following long-term selenium supplementation, but few data are available on the side effects associated with such supplementation and further studies are required. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/23046013/Selenium_and_the_thyroid_gland:_more_good_news_for_clinicians_ L2 - https://doi.org/10.1111/cen.12066 DB - PRIME DP - Unbound Medicine ER -