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Statin use and risk of prostate cancer: a meta-analysis of observational studies.
PLoS One. 2012; 7(10):e46691.Plos

Abstract

BACKGROUND

Emerging evidence suggests that statins may decrease the risk of cancers. However, available evidence on prostate cancer (PCa) is conflicting. We therefore examined the association between statin use and risk of PCa by conducting a detailed meta-analysis of all observational studies published regarding this subject.

METHODS

Literature search in PubMed database was undertaken through February 2012 looking for observational studies evaluating the association between statin use and risk of PCa. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model (DerSimonian and Laird method). Subgroup analyses, sensitivity analysis and cumulative meta-analysis were also performed.

RESULTS

A total of 27 (15 cohort and 12 case-control) studies contributed to the analysis. There was heterogeneity among the studies but no publication bias. Statin use significantly reduced the risk of both total PCa by 7% (RR 0.93, 95% CI 0.87-0.99, p = 0.03) and clinically important advanced PCa by 20% (RR 0.80, 95% CI 0.70-0.90, p<0.001). Long-term statin use did not significantly affect the risk of total PCa (RR 0.94, 95% CI 0.84-1.05, p = 0.31). Stratification by study design did not substantially influence the RR. Furthermore, sensitivity analysis confirmed the stability of results. Cumulative meta-analysis showed a change in trend of reporting risk from positive to negative in statin users between 1993 and 2011.

CONCLUSIONS

Our meta-analysis provides evidence supporting the hypothesis that statins reduce the risk of both total PCa and clinically important advanced PCa. Further research is needed to confirm these findings and to identify the underlying biological mechanisms.

Authors+Show Affiliations

Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab, India. drdeep97@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23049713

Citation

Bansal, Dipika, et al. "Statin Use and Risk of Prostate Cancer: a Meta-analysis of Observational Studies." PloS One, vol. 7, no. 10, 2012, pp. e46691.
Bansal D, Undela K, D'Cruz S, et al. Statin use and risk of prostate cancer: a meta-analysis of observational studies. PLoS ONE. 2012;7(10):e46691.
Bansal, D., Undela, K., D'Cruz, S., & Schifano, F. (2012). Statin use and risk of prostate cancer: a meta-analysis of observational studies. PloS One, 7(10), e46691. https://doi.org/10.1371/journal.pone.0046691
Bansal D, et al. Statin Use and Risk of Prostate Cancer: a Meta-analysis of Observational Studies. PLoS ONE. 2012;7(10):e46691. PubMed PMID: 23049713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin use and risk of prostate cancer: a meta-analysis of observational studies. AU - Bansal,Dipika, AU - Undela,Krishna, AU - D'Cruz,Sanjay, AU - Schifano,Fabrizio, Y1 - 2012/10/01/ PY - 2012/05/16/received PY - 2012/09/04/accepted PY - 2012/10/11/entrez PY - 2012/10/11/pubmed PY - 2013/2/23/medline SP - e46691 EP - e46691 JF - PloS one JO - PLoS ONE VL - 7 IS - 10 N2 - BACKGROUND: Emerging evidence suggests that statins may decrease the risk of cancers. However, available evidence on prostate cancer (PCa) is conflicting. We therefore examined the association between statin use and risk of PCa by conducting a detailed meta-analysis of all observational studies published regarding this subject. METHODS: Literature search in PubMed database was undertaken through February 2012 looking for observational studies evaluating the association between statin use and risk of PCa. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model (DerSimonian and Laird method). Subgroup analyses, sensitivity analysis and cumulative meta-analysis were also performed. RESULTS: A total of 27 (15 cohort and 12 case-control) studies contributed to the analysis. There was heterogeneity among the studies but no publication bias. Statin use significantly reduced the risk of both total PCa by 7% (RR 0.93, 95% CI 0.87-0.99, p = 0.03) and clinically important advanced PCa by 20% (RR 0.80, 95% CI 0.70-0.90, p<0.001). Long-term statin use did not significantly affect the risk of total PCa (RR 0.94, 95% CI 0.84-1.05, p = 0.31). Stratification by study design did not substantially influence the RR. Furthermore, sensitivity analysis confirmed the stability of results. Cumulative meta-analysis showed a change in trend of reporting risk from positive to negative in statin users between 1993 and 2011. CONCLUSIONS: Our meta-analysis provides evidence supporting the hypothesis that statins reduce the risk of both total PCa and clinically important advanced PCa. Further research is needed to confirm these findings and to identify the underlying biological mechanisms. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23049713/Statin_use_and_risk_of_prostate_cancer:_a_meta_analysis_of_observational_studies_ L2 - http://dx.plos.org/10.1371/journal.pone.0046691 DB - PRIME DP - Unbound Medicine ER -