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A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease.
PLoS One. 2012; 7(9):e45849.Plos

Abstract

BACKGROUND

Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease.

METHOD

Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number.

RESULTS

There were 17 study populations totaling 1773 cases and 2751 controls for ε2/ε3/ε4 polymorphism of Apo E gene. Overall comparison of alleles ε2 with ε3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68-1.05; P=0.31; I(2) =13%), and comparison of alleles ε4 with ε3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97-1.61; P=0.0003; I(2) =63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for ε4 allelic model (odds ratio [OR] =1.46; 95% CI: 1.05-2.02; p=0.0007; I(2) =65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in ε4 allelic model (OR=1.50; 95% CI: 1.03-2.19; p=0.0009; I(2) =72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male<30% studies for E2/2 genotypic model (OR=0.32; 95% CI: 0.07-1.49; p=0.16; I(2) =45%).

CONCLUSIONS

Our results reveal that Apo E gene ε4 allele is a risk factor of gallbladder stone disease, especially in elder people and Chinese population.

Authors+Show Affiliations

Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23049877

Citation

Xue, Pei, et al. "A Meta-analysis of Apolipoprotein E Gene Ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease." PloS One, vol. 7, no. 9, 2012, pp. e45849.
Xue P, Niu WQ, Jiang ZY, et al. A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease. PLoS One. 2012;7(9):e45849.
Xue, P., Niu, W. Q., Jiang, Z. Y., Zheng, M. H., & Fei, J. (2012). A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease. PloS One, 7(9), e45849. https://doi.org/10.1371/journal.pone.0045849
Xue P, et al. A Meta-analysis of Apolipoprotein E Gene Ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease. PLoS One. 2012;7(9):e45849. PubMed PMID: 23049877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease. AU - Xue,Pei, AU - Niu,Wen-Quan, AU - Jiang,Zhao-Yan, AU - Zheng,Min-Hua, AU - Fei,Jian, Y1 - 2012/09/25/ PY - 2012/05/24/received PY - 2012/08/23/accepted PY - 2012/10/11/entrez PY - 2012/10/11/pubmed PY - 2013/5/8/medline SP - e45849 EP - e45849 JF - PloS one JO - PLoS One VL - 7 IS - 9 N2 - BACKGROUND: Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease. METHOD: Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number. RESULTS: There were 17 study populations totaling 1773 cases and 2751 controls for ε2/ε3/ε4 polymorphism of Apo E gene. Overall comparison of alleles ε2 with ε3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68-1.05; P=0.31; I(2) =13%), and comparison of alleles ε4 with ε3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97-1.61; P=0.0003; I(2) =63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for ε4 allelic model (odds ratio [OR] =1.46; 95% CI: 1.05-2.02; p=0.0007; I(2) =65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in ε4 allelic model (OR=1.50; 95% CI: 1.03-2.19; p=0.0009; I(2) =72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male<30% studies for E2/2 genotypic model (OR=0.32; 95% CI: 0.07-1.49; p=0.16; I(2) =45%). CONCLUSIONS: Our results reveal that Apo E gene ε4 allele is a risk factor of gallbladder stone disease, especially in elder people and Chinese population. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23049877/A_meta_analysis_of_apolipoprotein_E_gene_��2/��3/��4_polymorphism_for_gallbladder_stone_disease_ L2 - https://dx.plos.org/10.1371/journal.pone.0045849 DB - PRIME DP - Unbound Medicine ER -