Tags

Type your tag names separated by a space and hit enter

Tracing bioavailability of ZnO nanoparticles using stable isotope labeling.
Environ Sci Technol. 2012 Nov 06; 46(21):12137-45.ES

Abstract

Zinc oxide nanoparticles (ZnO NPs) are widely used in commercial products and knowledge of their environmental fate is a priority for ecological protection. Here we synthesized model ZnO NPs that were made from and thus labeled with the stable isotope (68)Zn and this enables highly sensitive and selective detection of labeled components against high natural Zn background levels. We combine high precision stable isotope measurements and novel bioimaging techniques to characterize parallel water-borne exposures of the common mudshrimp Corophium volutator to (68)ZnO NPs, bulk (68)ZnO, and soluble (68)ZnCl(2) in the presence of sediment. C. volutator is an important component of coastal ecosystems where river-borne NPs will accumulate and is used on a routine basis for toxicity assessments. Our results demonstrate that ionic Zn from ZnO NPs is bioavailable to C. volutator and that Zn uptake is active. Bioavailability appears to be governed primarily by the dissolved Zn content of the water, whereby Zn uptake occurs via the aqueous phase and/or the ingestion of sediment particles with adsorbed Zn from dissolution of ZnO particles. The high sorption capacity of sediments for Zn thus enhances the potential for trophic transfer of Zn derived from readily soluble ZnO NPs. The uncertainties of our isotopic data are too large, however, to conclusively rule out any additional direct uptake route of ZnO NPs by C. volutator.

Authors+Show Affiliations

Department of Earth Science & Engineering, Imperial College London, SW7 2AZ, UK. fiona.larner04@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23050854

Citation

Larner, Fiona, et al. "Tracing Bioavailability of ZnO Nanoparticles Using Stable Isotope Labeling." Environmental Science & Technology, vol. 46, no. 21, 2012, pp. 12137-45.
Larner F, Dogra Y, Dybowska A, et al. Tracing bioavailability of ZnO nanoparticles using stable isotope labeling. Environ Sci Technol. 2012;46(21):12137-45.
Larner, F., Dogra, Y., Dybowska, A., Fabrega, J., Stolpe, B., Bridgestock, L. J., Goodhead, R., Weiss, D. J., Moger, J., Lead, J. R., Valsami-Jones, E., Tyler, C. R., Galloway, T. S., & Rehkämper, M. (2012). Tracing bioavailability of ZnO nanoparticles using stable isotope labeling. Environmental Science & Technology, 46(21), 12137-45. https://doi.org/10.1021/es302602j
Larner F, et al. Tracing Bioavailability of ZnO Nanoparticles Using Stable Isotope Labeling. Environ Sci Technol. 2012 Nov 6;46(21):12137-45. PubMed PMID: 23050854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tracing bioavailability of ZnO nanoparticles using stable isotope labeling. AU - Larner,Fiona, AU - Dogra,Yuktee, AU - Dybowska,Agnieszka, AU - Fabrega,Julia, AU - Stolpe,Björn, AU - Bridgestock,Luke J, AU - Goodhead,Rhys, AU - Weiss,Dominik J, AU - Moger,Julian, AU - Lead,Jamie R, AU - Valsami-Jones,Eugenia, AU - Tyler,Charles R, AU - Galloway,Tamara S, AU - Rehkämper,Mark, Y1 - 2012/10/22/ PY - 2012/10/12/entrez PY - 2012/10/12/pubmed PY - 2013/4/20/medline SP - 12137 EP - 45 JF - Environmental science & technology JO - Environ Sci Technol VL - 46 IS - 21 N2 - Zinc oxide nanoparticles (ZnO NPs) are widely used in commercial products and knowledge of their environmental fate is a priority for ecological protection. Here we synthesized model ZnO NPs that were made from and thus labeled with the stable isotope (68)Zn and this enables highly sensitive and selective detection of labeled components against high natural Zn background levels. We combine high precision stable isotope measurements and novel bioimaging techniques to characterize parallel water-borne exposures of the common mudshrimp Corophium volutator to (68)ZnO NPs, bulk (68)ZnO, and soluble (68)ZnCl(2) in the presence of sediment. C. volutator is an important component of coastal ecosystems where river-borne NPs will accumulate and is used on a routine basis for toxicity assessments. Our results demonstrate that ionic Zn from ZnO NPs is bioavailable to C. volutator and that Zn uptake is active. Bioavailability appears to be governed primarily by the dissolved Zn content of the water, whereby Zn uptake occurs via the aqueous phase and/or the ingestion of sediment particles with adsorbed Zn from dissolution of ZnO particles. The high sorption capacity of sediments for Zn thus enhances the potential for trophic transfer of Zn derived from readily soluble ZnO NPs. The uncertainties of our isotopic data are too large, however, to conclusively rule out any additional direct uptake route of ZnO NPs by C. volutator. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/23050854/Tracing_bioavailability_of_ZnO_nanoparticles_using_stable_isotope_labeling_ L2 - https://doi.org/10.1021/es302602j DB - PRIME DP - Unbound Medicine ER -