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Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression.
Ann N Y Acad Sci 2012; 1271:44-52AN

Abstract

Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides-i.e., sulfur metabolites in garlic oil-have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer. DATS inhibits cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis, including the caspase-dependent and -independent pathways. This short review focuses on the molecular mechanisms of garlic-derived allyl sulfides on skin cancer prevention.

Authors+Show Affiliations

Institute of Food Science and Technology, National Taiwan University, Taipei, ROC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23050963

Citation

Wang, Hsiao-Chi, et al. "Molecular Mechanisms of Garlic-derived Allyl Sulfides in the Inhibition of Skin Cancer Progression." Annals of the New York Academy of Sciences, vol. 1271, 2012, pp. 44-52.
Wang HC, Pao J, Lin SY, et al. Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Ann N Y Acad Sci. 2012;1271:44-52.
Wang, H. C., Pao, J., Lin, S. Y., & Sheen, L. Y. (2012). Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Annals of the New York Academy of Sciences, 1271, pp. 44-52. doi:10.1111/j.1749-6632.2012.06743.x.
Wang HC, et al. Molecular Mechanisms of Garlic-derived Allyl Sulfides in the Inhibition of Skin Cancer Progression. Ann N Y Acad Sci. 2012;1271:44-52. PubMed PMID: 23050963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. AU - Wang,Hsiao-Chi, AU - Pao,Jung, AU - Lin,Shuw-Yuan, AU - Sheen,Lee-Yan, PY - 2012/10/12/entrez PY - 2012/10/12/pubmed PY - 2013/1/23/medline SP - 44 EP - 52 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1271 N2 - Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides-i.e., sulfur metabolites in garlic oil-have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer. DATS inhibits cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis, including the caspase-dependent and -independent pathways. This short review focuses on the molecular mechanisms of garlic-derived allyl sulfides on skin cancer prevention. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/23050963/Molecular_mechanisms_of_garlic_derived_allyl_sulfides_in_the_inhibition_of_skin_cancer_progression_ L2 - https://doi.org/10.1111/j.1749-6632.2012.06743.x DB - PRIME DP - Unbound Medicine ER -