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Telmisartan 80 mg/hydrochlorothiazide 25 mg single-pill combination in the treatment of hypertension.
Expert Opin Pharmacother. 2012 Nov; 13(16):2417-25.EO

Abstract

INTRODUCTION

International guidelines emphasize the importance of blood pressure (BP) control to reduce cardiovascular risk. Telmisartan, an angiotensin II receptor blocker, provides large BP reductions and also prevents cardiovascular events in patients at high risk. The thiazide diuretic, hydrochlorothiazide (HCTZ), has a complementary mode of action, and combination with telmisartan is an established and rational treatment option for patients uncontrolled on monotherapy. A single-pill combination (SPC) of telmisartan 80 mg with high-strength HCTZ 25 mg (T80/H25) is widely available.

AREA COVERED

Clinical data on T80/H25 SPC for the management of hypertension was identified via MEDLINE searches. T80/H25 SPC provides greater BP reductions and higher goal achievement rates in patients who cannot achieve BP goal with T80/HCTZ 12.5 mg SPC, and also as initial therapy compared with T80 monotherapy. T80/H25 also reduced BP significantly more than valsartan 160 mg/H25 combination, and demonstrated favorable tolerability in clinical trials.

EXPERT OPINION

Patients with hypertension often do not achieve BP goal, even when treated, leaving them at increased cardiovascular risk. In part this is due to poor adherence, which can be exacerbated by treatment side effects. High BP goal achievement with SPC T80/H25, with maintained tolerability, provides a treatment option for increasing BP control.

Authors+Show Affiliations

Hospital 12 de Octubre, Nephrology, Carreter de Cordoba s/n, Madrid, Spain. ruilope@ad-hocbox.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23051558

Citation

Ruilope, L M., and Helmut Schumacher. "Telmisartan 80 Mg/hydrochlorothiazide 25 Mg Single-pill Combination in the Treatment of Hypertension." Expert Opinion On Pharmacotherapy, vol. 13, no. 16, 2012, pp. 2417-25.
Ruilope LM, Schumacher H. Telmisartan 80 mg/hydrochlorothiazide 25 mg single-pill combination in the treatment of hypertension. Expert Opin Pharmacother. 2012;13(16):2417-25.
Ruilope, L. M., & Schumacher, H. (2012). Telmisartan 80 mg/hydrochlorothiazide 25 mg single-pill combination in the treatment of hypertension. Expert Opinion On Pharmacotherapy, 13(16), 2417-25. https://doi.org/10.1517/14656566.2012.733698
Ruilope LM, Schumacher H. Telmisartan 80 Mg/hydrochlorothiazide 25 Mg Single-pill Combination in the Treatment of Hypertension. Expert Opin Pharmacother. 2012;13(16):2417-25. PubMed PMID: 23051558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telmisartan 80 mg/hydrochlorothiazide 25 mg single-pill combination in the treatment of hypertension. AU - Ruilope,L M, AU - Schumacher,Helmut, Y1 - 2012/10/10/ PY - 2012/10/12/entrez PY - 2012/10/12/pubmed PY - 2013/3/6/medline SP - 2417 EP - 25 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 13 IS - 16 N2 - INTRODUCTION: International guidelines emphasize the importance of blood pressure (BP) control to reduce cardiovascular risk. Telmisartan, an angiotensin II receptor blocker, provides large BP reductions and also prevents cardiovascular events in patients at high risk. The thiazide diuretic, hydrochlorothiazide (HCTZ), has a complementary mode of action, and combination with telmisartan is an established and rational treatment option for patients uncontrolled on monotherapy. A single-pill combination (SPC) of telmisartan 80 mg with high-strength HCTZ 25 mg (T80/H25) is widely available. AREA COVERED: Clinical data on T80/H25 SPC for the management of hypertension was identified via MEDLINE searches. T80/H25 SPC provides greater BP reductions and higher goal achievement rates in patients who cannot achieve BP goal with T80/HCTZ 12.5 mg SPC, and also as initial therapy compared with T80 monotherapy. T80/H25 also reduced BP significantly more than valsartan 160 mg/H25 combination, and demonstrated favorable tolerability in clinical trials. EXPERT OPINION: Patients with hypertension often do not achieve BP goal, even when treated, leaving them at increased cardiovascular risk. In part this is due to poor adherence, which can be exacerbated by treatment side effects. High BP goal achievement with SPC T80/H25, with maintained tolerability, provides a treatment option for increasing BP control. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/23051558/Telmisartan_80_mg/hydrochlorothiazide_25_mg_single_pill_combination_in_the_treatment_of_hypertension_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656566.2012.733698 DB - PRIME DP - Unbound Medicine ER -