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Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study.
Environ Health Perspect. 2013 Jan; 121(1):138-44.EH

Abstract

BACKGROUND

Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain development, no studies have investigated relations between BPA exposure and thyroid function in pregnant women or neonates.

OBJECTIVE

Our goal was to evaluate whether exposure to BPA during pregnancy is related to thyroid hormone levels in pregnant women and neonates.

METHODS

We measured BPA concentration in urine samples collected during the first and second half of pregnancy in 476 women participating in the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) study. We also measured free thyroxine (T4), total T4, and thyroid-stimulating hormone (TSH) in women during pregnancy, and TSH in neonates.

RESULTS

Associations between the average of the two BPA measurements and maternal thyroid hormone levels were not statistically significant. Of the two BPA measurements, only the one taken closest in time to the TH measurement was significantly associated with a reduction in total T4 (β = -0.13 µg/dL per log2 unit; 95% CI: -0.25, 0.00). The average of the maternal BPA concentrations was associated with reduced TSH in boys (-9.9% per log2 unit; 95% CI: -15.9%, -3.5%) but not in girls. Among boys, the relation was stronger when BPA was measured in the third trimester of pregnancy and decreased with time between BPA and TH measurements.

CONCLUSION

Results suggest that exposure to BPA during pregnancy is related to reduced total T4 in pregnant women and decreased TSH in male neonates. Findings may have implications for fetal and neonatal development.

Authors+Show Affiliations

Center for Children’s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94704-7392, USA. chevrier@berkeley.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23052180

Citation

Chevrier, Jonathan, et al. "Maternal Urinary Bisphenol a During Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study." Environmental Health Perspectives, vol. 121, no. 1, 2013, pp. 138-44.
Chevrier J, Gunier RB, Bradman A, et al. Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environ Health Perspect. 2013;121(1):138-44.
Chevrier, J., Gunier, R. B., Bradman, A., Holland, N. T., Calafat, A. M., Eskenazi, B., & Harley, K. G. (2013). Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environmental Health Perspectives, 121(1), 138-44. https://doi.org/10.1289/ehp.1205092
Chevrier J, et al. Maternal Urinary Bisphenol a During Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study. Environ Health Perspect. 2013;121(1):138-44. PubMed PMID: 23052180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. AU - Chevrier,Jonathan, AU - Gunier,Robert B, AU - Bradman,Asa, AU - Holland,Nina T, AU - Calafat,Antonia M, AU - Eskenazi,Brenda, AU - Harley,Kim G, Y1 - 2012/10/04/ PY - 2012/02/13/received PY - 2012/09/25/accepted PY - 2012/10/12/entrez PY - 2012/10/12/pubmed PY - 2013/7/9/medline SP - 138 EP - 44 JF - Environmental health perspectives JO - Environ Health Perspect VL - 121 IS - 1 N2 - BACKGROUND: Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain development, no studies have investigated relations between BPA exposure and thyroid function in pregnant women or neonates. OBJECTIVE: Our goal was to evaluate whether exposure to BPA during pregnancy is related to thyroid hormone levels in pregnant women and neonates. METHODS: We measured BPA concentration in urine samples collected during the first and second half of pregnancy in 476 women participating in the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) study. We also measured free thyroxine (T4), total T4, and thyroid-stimulating hormone (TSH) in women during pregnancy, and TSH in neonates. RESULTS: Associations between the average of the two BPA measurements and maternal thyroid hormone levels were not statistically significant. Of the two BPA measurements, only the one taken closest in time to the TH measurement was significantly associated with a reduction in total T4 (β = -0.13 µg/dL per log2 unit; 95% CI: -0.25, 0.00). The average of the maternal BPA concentrations was associated with reduced TSH in boys (-9.9% per log2 unit; 95% CI: -15.9%, -3.5%) but not in girls. Among boys, the relation was stronger when BPA was measured in the third trimester of pregnancy and decreased with time between BPA and TH measurements. CONCLUSION: Results suggest that exposure to BPA during pregnancy is related to reduced total T4 in pregnant women and decreased TSH in male neonates. Findings may have implications for fetal and neonatal development. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/23052180/Maternal_urinary_bisphenol_a_during_pregnancy_and_maternal_and_neonatal_thyroid_function_in_the_CHAMACOS_study_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.1205092?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -