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Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes.
Mol Biol Rep. 2013 Jan; 40(1):211-5.MB

Abstract

The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8 %) and 774 (38.2 %), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95 % CI 1.421, 1.827, p < 1 × 10(-8)) without between-study heterogeneity (I(2) = 32.5, p = 0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values = 0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95 % CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. lyhcgh@korea.ac.krNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23054006

Citation

Lee, Young Ho, and Gwan Gyu Song. "Meta-analysis of the Family-based Association Between the PTPN22 C1858T Polymorphism and Type 1 Diabetes." Molecular Biology Reports, vol. 40, no. 1, 2013, pp. 211-5.
Lee YH, Song GG. Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes. Mol Biol Rep. 2013;40(1):211-5.
Lee, Y. H., & Song, G. G. (2013). Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes. Molecular Biology Reports, 40(1), 211-5. https://doi.org/10.1007/s11033-012-2051-8
Lee YH, Song GG. Meta-analysis of the Family-based Association Between the PTPN22 C1858T Polymorphism and Type 1 Diabetes. Mol Biol Rep. 2013;40(1):211-5. PubMed PMID: 23054006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes. AU - Lee,Young Ho, AU - Song,Gwan Gyu, Y1 - 2012/10/08/ PY - 2012/04/06/received PY - 2012/10/02/accepted PY - 2012/10/12/entrez PY - 2012/10/12/pubmed PY - 2013/6/15/medline SP - 211 EP - 5 JF - Molecular biology reports JO - Mol. Biol. Rep. VL - 40 IS - 1 N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8 %) and 774 (38.2 %), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95 % CI 1.421, 1.827, p < 1 × 10(-8)) without between-study heterogeneity (I(2) = 32.5, p = 0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values = 0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95 % CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/23054006/Meta_analysis_of_the_family_based_association_between_the_PTPN22_C1858T_polymorphism_and_type_1_diabetes_ L2 - https://doi.org/10.1007/s11033-012-2051-8 DB - PRIME DP - Unbound Medicine ER -