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Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal).
Curr Allergy Asthma Rep 2013; 13(1):72-7CA

Abstract

Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: (1) immediate onset anaphylaxis during first exposure to intravenous cetuximab, and (2) delayed onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g., beef and pork). The results of our studies strongly suggest that tick bites are a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the southern, eastern and central United States. Patients with IgE Ab to alpha-gal continue to emerge and, increasingly, these cases involve children. This IgE Ab response cross-reacts with cat and dog but does not appear to pose a risk for asthma; however, it may impair diagnostic testing in some situations.

Authors+Show Affiliations

Department of Internal Medicine & Pediatrics, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA. spc7w@virginia.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

23054628

Citation

Commins, Scott P., and Thomas A E. Platts-Mills. "Delayed Anaphylaxis to Red Meat in Patients With IgE Specific for Galactose Alpha-1,3-galactose (alpha-gal)." Current Allergy and Asthma Reports, vol. 13, no. 1, 2013, pp. 72-7.
Commins SP, Platts-Mills TA. Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal). Curr Allergy Asthma Rep. 2013;13(1):72-7.
Commins, S. P., & Platts-Mills, T. A. (2013). Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal). Current Allergy and Asthma Reports, 13(1), pp. 72-7. doi:10.1007/s11882-012-0315-y.
Commins SP, Platts-Mills TA. Delayed Anaphylaxis to Red Meat in Patients With IgE Specific for Galactose Alpha-1,3-galactose (alpha-gal). Curr Allergy Asthma Rep. 2013;13(1):72-7. PubMed PMID: 23054628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal). AU - Commins,Scott P, AU - Platts-Mills,Thomas A E, PY - 2012/10/12/entrez PY - 2012/10/12/pubmed PY - 2013/4/19/medline SP - 72 EP - 7 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 13 IS - 1 N2 - Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: (1) immediate onset anaphylaxis during first exposure to intravenous cetuximab, and (2) delayed onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g., beef and pork). The results of our studies strongly suggest that tick bites are a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the southern, eastern and central United States. Patients with IgE Ab to alpha-gal continue to emerge and, increasingly, these cases involve children. This IgE Ab response cross-reacts with cat and dog but does not appear to pose a risk for asthma; however, it may impair diagnostic testing in some situations. SN - 1534-6315 UR - https://www.unboundmedicine.com/medline/citation/23054628/Delayed_anaphylaxis_to_red_meat_in_patients_with_IgE_specific_for_galactose_alpha_13_galactose__alpha_gal__ L2 - https://dx.doi.org/10.1007/s11882-012-0315-y DB - PRIME DP - Unbound Medicine ER -