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Food allergy and the development of asthma symptoms.
Int J Immunopathol Pharmacol 2012 Jul-Sep; 25(3):731-40IJ

Abstract

Allergies are multifactorial diseases the onset of which depends also on genetic and environmental factors in early life. Thus, environmental factors can affect the immune response and modify lung development, thereby leading to asthma. The role of the factors used to date to predict asthma development is modest, and clinical criteria should always be considered in association with familiarity for atopy. The aim of this study is to evaluate the risk of asthma in a population with positive skin prick test (SPT) (which is a reliable marker of atopy) to food allergens, regardless of clinical manifestations in the early years of life. The cohort of children enrolled in our study who had a positive SPT to food in the first three years of life had a prevalence of asthma after 7-14 years, double that of the general pediatric population. This prevalence increased significantly in patients with SPT positivity for food and inhalant allergens. We identified a correlation between the sensitization profile in children under the age of 36 months and the development of asthma during a period of 7-14 years. This study confirms that early sensitization is an important risk factor for the development of asthma, particularly in association with sensitization to inhalants, and that the persistence of food sensitization in school-age children and adolescents is associated to more severe asthma.

Authors+Show Affiliations

Department of Pediatrics, Sapienza University, Rome, Italy. annamaria.zicari@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23058023

Citation

Zicari, A M., et al. "Food Allergy and the Development of Asthma Symptoms." International Journal of Immunopathology and Pharmacology, vol. 25, no. 3, 2012, pp. 731-40.
Zicari AM, Indinnimeo L, De Castro G, et al. Food allergy and the development of asthma symptoms. Int J Immunopathol Pharmacol. 2012;25(3):731-40.
Zicari, A. M., Indinnimeo, L., De Castro, G., Zappalà, D., Tancredi, G., Bonci, E., ... Duse, M. (2012). Food allergy and the development of asthma symptoms. International Journal of Immunopathology and Pharmacology, 25(3), pp. 731-40.
Zicari AM, et al. Food Allergy and the Development of Asthma Symptoms. Int J Immunopathol Pharmacol. 2012;25(3):731-40. PubMed PMID: 23058023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food allergy and the development of asthma symptoms. AU - Zicari,A M, AU - Indinnimeo,L, AU - De Castro,G, AU - Zappalà,D, AU - Tancredi,G, AU - Bonci,E, AU - Celani,C, AU - Duse,M, PY - 2012/10/13/entrez PY - 2012/10/13/pubmed PY - 2012/12/12/medline SP - 731 EP - 40 JF - International journal of immunopathology and pharmacology JO - Int J Immunopathol Pharmacol VL - 25 IS - 3 N2 - Allergies are multifactorial diseases the onset of which depends also on genetic and environmental factors in early life. Thus, environmental factors can affect the immune response and modify lung development, thereby leading to asthma. The role of the factors used to date to predict asthma development is modest, and clinical criteria should always be considered in association with familiarity for atopy. The aim of this study is to evaluate the risk of asthma in a population with positive skin prick test (SPT) (which is a reliable marker of atopy) to food allergens, regardless of clinical manifestations in the early years of life. The cohort of children enrolled in our study who had a positive SPT to food in the first three years of life had a prevalence of asthma after 7-14 years, double that of the general pediatric population. This prevalence increased significantly in patients with SPT positivity for food and inhalant allergens. We identified a correlation between the sensitization profile in children under the age of 36 months and the development of asthma during a period of 7-14 years. This study confirms that early sensitization is an important risk factor for the development of asthma, particularly in association with sensitization to inhalants, and that the persistence of food sensitization in school-age children and adolescents is associated to more severe asthma. SN - 0394-6320 UR - https://www.unboundmedicine.com/medline/citation/23058023/Food_allergy_and_the_development_of_asthma_symptoms_ L2 - http://journals.sagepub.com/doi/full/10.1177/039463201202500319?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -