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Cross neutralisation of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms.
Trans R Soc Trop Med Hyg. 2012 Dec; 106(12):731-7.TR

Abstract

Cross neutralisation of venoms by antivenom raised against closely-related species has been well documented. The spectrum of paraspecific protection of antivenom raised against Asiatic Naja and Bungarus (krait) venoms, however, has not been fully investigated. In this study, we examined the cross neutralisation of venoms from common Southeast Asian cobras and kraits by two widely used polyvalent antivenoms produced in India: Vins Polyvalent Antivenom (VPAV) and Bharat Polyvalent Antivenom (BPAV), using both in vitro and in vivo mouse protection assays. BPAV was only moderately effective against venoms of N. kaouthia (Thailand) and N. sumatrana, and either very weakly effective or totally ineffective against the other cobra and krait venoms. VPAV, on the other hand, neutralised effectively all the Southeast Asian Naja venoms tested, as well as N. naja, B. candidus and Ophiophagus hannah venoms, but the potency ranges from effective to weakly effective. In an in vivo rodent model, VPAV also neutralised the lethality of venoms from Asiatic Naja and B. candidus. In anesthetised rat studies, both antivenoms effectively protected against the N. kaouthia venom-induced cardio-respiratory depressant and neuromuscular blocking effects. Overall, our results suggest that VPAV could be used as alternative antivenom for the treatment of elapid envenomation in Southeast Asian regions including Malaysia, Thailand and certain regions of Indonesia.

Authors+Show Affiliations

Department of Pharmacology, CENAR, University of Malaya, Kuala Lumpur, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23062608

Citation

Leong, Poh Kuan, et al. "Cross Neutralisation of Southeast Asian Cobra and Krait Venoms By Indian Polyvalent Antivenoms." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 106, no. 12, 2012, pp. 731-7.
Leong PK, Tan NH, Fung SY, et al. Cross neutralisation of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Trans R Soc Trop Med Hyg. 2012;106(12):731-7.
Leong, P. K., Tan, N. H., Fung, S. Y., & Sim, S. M. (2012). Cross neutralisation of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Transactions of the Royal Society of Tropical Medicine and Hygiene, 106(12), 731-7. https://doi.org/10.1016/j.trstmh.2012.07.009
Leong PK, et al. Cross Neutralisation of Southeast Asian Cobra and Krait Venoms By Indian Polyvalent Antivenoms. Trans R Soc Trop Med Hyg. 2012;106(12):731-7. PubMed PMID: 23062608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross neutralisation of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. AU - Leong,Poh Kuan, AU - Tan,Nget Hong, AU - Fung,Shin Yee, AU - Sim,Si Mui, Y1 - 2012/10/11/ PY - 2011/07/05/received PY - 2012/07/16/revised PY - 2012/07/16/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/6/5/medline SP - 731 EP - 7 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 106 IS - 12 N2 - Cross neutralisation of venoms by antivenom raised against closely-related species has been well documented. The spectrum of paraspecific protection of antivenom raised against Asiatic Naja and Bungarus (krait) venoms, however, has not been fully investigated. In this study, we examined the cross neutralisation of venoms from common Southeast Asian cobras and kraits by two widely used polyvalent antivenoms produced in India: Vins Polyvalent Antivenom (VPAV) and Bharat Polyvalent Antivenom (BPAV), using both in vitro and in vivo mouse protection assays. BPAV was only moderately effective against venoms of N. kaouthia (Thailand) and N. sumatrana, and either very weakly effective or totally ineffective against the other cobra and krait venoms. VPAV, on the other hand, neutralised effectively all the Southeast Asian Naja venoms tested, as well as N. naja, B. candidus and Ophiophagus hannah venoms, but the potency ranges from effective to weakly effective. In an in vivo rodent model, VPAV also neutralised the lethality of venoms from Asiatic Naja and B. candidus. In anesthetised rat studies, both antivenoms effectively protected against the N. kaouthia venom-induced cardio-respiratory depressant and neuromuscular blocking effects. Overall, our results suggest that VPAV could be used as alternative antivenom for the treatment of elapid envenomation in Southeast Asian regions including Malaysia, Thailand and certain regions of Indonesia. SN - 1878-3503 UR - https://www.unboundmedicine.com/medline/citation/23062608/Cross_neutralisation_of_Southeast_Asian_cobra_and_krait_venoms_by_Indian_polyvalent_antivenoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(12)00151-4 DB - PRIME DP - Unbound Medicine ER -