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Cooperative interaction between the basolateral amygdala and ventral tegmental area modulates the consolidation of inhibitory avoidance memory.

Abstract

The aim of the current study was to examine the existence of a cooperative interaction between the basolateral nucleus of amygdala (BLA) and the ventral tegmental area (VTA) in inhibitory avoidance task. The BLA and the VTA regions of adult male Wistar rats were simultaneously cannulated and memory consolidation was measured in a step-through type inhibitory avoidance apparatus. Post-training microinjection of muscimol, a potent GABA-A receptor agonist (0.01-0.02 μg/rat), into the VTA impaired memory in a dose-dependent manner. Post-training intra-BLA microinjection of NMDA (0.02-0.04 μg/rat), 5 min before the intra-VTA injection of muscimol (0.02 μg/rat), attenuated muscimol-induced memory impairment. Microinjection of a NMDA receptor antagonist, D-AP5 (0.02-0.06 μg/rat) into the BLA inhibited NMDA effect on the memory impairment induced by intra-VTA microinjection of muscimol. On the other hand, post-training intra-BLA microinjection of muscimol (0.02-0.04 μg/rat) dose-dependently decreased step-through latency, indicating an impairing effect on memory. This impairing effect was however significantly attenuated by intra-VTA microinjection of NMDA (0.01-0.03 μg/rat). Intra-VTA microinjection of D-AP5 (0.02-0.08 μg/rat), 5 min prior to NMDA injection, inhibited NMDA response on the impairing effect induced by intra-BLA microinjection of muscimol. It should be considered that post-training microinjection of the same doses of NMDA or D-AP5 into the BLA or the VTA alone had no effect on memory consolidation. The data suggest that the relationship between the BLA and the VTA in mediating memory consolidation in inhibitory avoidance learning may be dependent on a cooperative interaction between the glutamatergic and GABAergic systems via NMDA and GABA-A receptors.

Authors+Show Affiliations

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23063440

Citation

Nazari-Serenjeh, Farzaneh, and Ameneh Rezayof. "Cooperative Interaction Between the Basolateral Amygdala and Ventral Tegmental Area Modulates the Consolidation of Inhibitory Avoidance Memory." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 40, 2013, pp. 54-61.
Nazari-Serenjeh F, Rezayof A. Cooperative interaction between the basolateral amygdala and ventral tegmental area modulates the consolidation of inhibitory avoidance memory. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:54-61.
Nazari-Serenjeh, F., & Rezayof, A. (2013). Cooperative interaction between the basolateral amygdala and ventral tegmental area modulates the consolidation of inhibitory avoidance memory. Progress in Neuro-psychopharmacology & Biological Psychiatry, 40, 54-61. https://doi.org/10.1016/j.pnpbp.2012.10.003
Nazari-Serenjeh F, Rezayof A. Cooperative Interaction Between the Basolateral Amygdala and Ventral Tegmental Area Modulates the Consolidation of Inhibitory Avoidance Memory. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:54-61. PubMed PMID: 23063440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cooperative interaction between the basolateral amygdala and ventral tegmental area modulates the consolidation of inhibitory avoidance memory. AU - Nazari-Serenjeh,Farzaneh, AU - Rezayof,Ameneh, Y1 - 2012/10/12/ PY - 2012/07/15/received PY - 2012/09/16/revised PY - 2012/10/04/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/3/27/medline SP - 54 EP - 61 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 40 N2 - The aim of the current study was to examine the existence of a cooperative interaction between the basolateral nucleus of amygdala (BLA) and the ventral tegmental area (VTA) in inhibitory avoidance task. The BLA and the VTA regions of adult male Wistar rats were simultaneously cannulated and memory consolidation was measured in a step-through type inhibitory avoidance apparatus. Post-training microinjection of muscimol, a potent GABA-A receptor agonist (0.01-0.02 μg/rat), into the VTA impaired memory in a dose-dependent manner. Post-training intra-BLA microinjection of NMDA (0.02-0.04 μg/rat), 5 min before the intra-VTA injection of muscimol (0.02 μg/rat), attenuated muscimol-induced memory impairment. Microinjection of a NMDA receptor antagonist, D-AP5 (0.02-0.06 μg/rat) into the BLA inhibited NMDA effect on the memory impairment induced by intra-VTA microinjection of muscimol. On the other hand, post-training intra-BLA microinjection of muscimol (0.02-0.04 μg/rat) dose-dependently decreased step-through latency, indicating an impairing effect on memory. This impairing effect was however significantly attenuated by intra-VTA microinjection of NMDA (0.01-0.03 μg/rat). Intra-VTA microinjection of D-AP5 (0.02-0.08 μg/rat), 5 min prior to NMDA injection, inhibited NMDA response on the impairing effect induced by intra-BLA microinjection of muscimol. It should be considered that post-training microinjection of the same doses of NMDA or D-AP5 into the BLA or the VTA alone had no effect on memory consolidation. The data suggest that the relationship between the BLA and the VTA in mediating memory consolidation in inhibitory avoidance learning may be dependent on a cooperative interaction between the glutamatergic and GABAergic systems via NMDA and GABA-A receptors. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/23063440/Cooperative_interaction_between_the_basolateral_amygdala_and_ventral_tegmental_area_modulates_the_consolidation_of_inhibitory_avoidance_memory_ DB - PRIME DP - Unbound Medicine ER -