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A potential role for GPR55 in gastrointestinal functions.
Curr Opin Pharmacol. 2012 Dec; 12(6):653-8.CO

Abstract

Despite sharing little homology (10-15%) with cannabinoid-1 (CB(1)) and cannabinoid-2 (CB(2)) receptors, the G protein-coupled receptor 55 (GPR55) was initially thought to be a new member of the cannabinoid receptor family. Apart from being activated by various exogenous cannabinoids, GPR55 is also activated by endocannabinoids like anandamide, which is found in organs with high GPR55 expression such as the brain and the gastrointestinal (GI) tract. The phylogenetic distance to the classical CB receptors and its pharmacological responsiveness to certain cannabinoids suggests that GPR55 may constitute a novel class of cannabinoid receptors. GPR55 influences mechanisms in the nervous system, vasculature, kidney and bone. Recent research revealed that GPR55 is also involved in cancer development and inflammatory pain. Because of its presence in the GI tract, several studies have started to focus on the involvement of GPR55 in the physiology and pathophysiology of the gut. The following article intends to discuss the potential role of GPR55 in GI functions.

Authors+Show Affiliations

Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23063456

Citation

Schicho, Rudolf, and Martin Storr. "A Potential Role for GPR55 in Gastrointestinal Functions." Current Opinion in Pharmacology, vol. 12, no. 6, 2012, pp. 653-8.
Schicho R, Storr M. A potential role for GPR55 in gastrointestinal functions. Curr Opin Pharmacol. 2012;12(6):653-8.
Schicho, R., & Storr, M. (2012). A potential role for GPR55 in gastrointestinal functions. Current Opinion in Pharmacology, 12(6), 653-8. https://doi.org/10.1016/j.coph.2012.09.009
Schicho R, Storr M. A Potential Role for GPR55 in Gastrointestinal Functions. Curr Opin Pharmacol. 2012;12(6):653-8. PubMed PMID: 23063456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A potential role for GPR55 in gastrointestinal functions. AU - Schicho,Rudolf, AU - Storr,Martin, Y1 - 2012/10/10/ PY - 2012/03/23/received PY - 2012/07/29/revised PY - 2012/09/19/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/5/11/medline SP - 653 EP - 8 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 12 IS - 6 N2 - Despite sharing little homology (10-15%) with cannabinoid-1 (CB(1)) and cannabinoid-2 (CB(2)) receptors, the G protein-coupled receptor 55 (GPR55) was initially thought to be a new member of the cannabinoid receptor family. Apart from being activated by various exogenous cannabinoids, GPR55 is also activated by endocannabinoids like anandamide, which is found in organs with high GPR55 expression such as the brain and the gastrointestinal (GI) tract. The phylogenetic distance to the classical CB receptors and its pharmacological responsiveness to certain cannabinoids suggests that GPR55 may constitute a novel class of cannabinoid receptors. GPR55 influences mechanisms in the nervous system, vasculature, kidney and bone. Recent research revealed that GPR55 is also involved in cancer development and inflammatory pain. Because of its presence in the GI tract, several studies have started to focus on the involvement of GPR55 in the physiology and pathophysiology of the gut. The following article intends to discuss the potential role of GPR55 in GI functions. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/23063456/A_potential_role_for_GPR55_in_gastrointestinal_functions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(12)00178-6 DB - PRIME DP - Unbound Medicine ER -