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Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome.
J Cardiol. 2012 Dec; 60(6):438-42.JC

Abstract

BACKGROUND

Chronic kidney disease (CKD) is closely associated with a higher risk of cardiovascular disease. However, whether patients with acute coronary syndrome (ACS) and CKD are at increased risk for long-term mortality after coronary revascularization remains unknown.

METHODS AND RESULTS

Data from consecutive patients with ACS who had undergone coronary revascularization, including percutaneous coronary intervention (PCI) and coronary artery bypass surgery (CABG) were analyzed. The estimated glomerular filtration rate (eGFR) was calculated using the current Japanese equation and CKD was defined as eGFR < 60 mL/min/1.73 m(2). Among 375 enrolled patients with ACS, 75 (20.0%) had CKD. During a follow-up period of 10.0 ± 3.4 years, the total number of deaths was 80 (21.3%), of which 36 (9.6%) were due to cardiovascular causes. Kaplan-Meier analysis showed that the presence of CKD was associated with a significant increase in mortality from all causes (log-rank test, p<0.001) and cardiovascular mortality (p<0.001). Cox proportional-hazard analysis revealed that CKD increased the risk of mortality with a hazard ratio of 2.31 (95% confidence interval (CI): 1.25-4.29, p=0.008) and of cardiovascular death with a hazard ratio of 3.76 (95% CI: 1.60-8.80, p=0.002) in patients with ACS.

CONCLUSIONS

CKD is a powerful determinant of long-term all-cause and cardiovascular mortality after ACS.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Juntendo University, School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23063662

Citation

Dohi, Tomotaka, et al. "Prognostic Impact of Chronic Kidney Disease On 10-year Clinical Outcomes Among Patients With Acute Coronary Syndrome." Journal of Cardiology, vol. 60, no. 6, 2012, pp. 438-42.
Dohi T, Kasai T, Miyauchi K, et al. Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome. J Cardiol. 2012;60(6):438-42.
Dohi, T., Kasai, T., Miyauchi, K., Takasu, K., Kajimoto, K., Kubota, N., Amano, A., & Daida, H. (2012). Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome. Journal of Cardiology, 60(6), 438-42. https://doi.org/10.1016/j.jjcc.2012.08.007
Dohi T, et al. Prognostic Impact of Chronic Kidney Disease On 10-year Clinical Outcomes Among Patients With Acute Coronary Syndrome. J Cardiol. 2012;60(6):438-42. PubMed PMID: 23063662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome. AU - Dohi,Tomotaka, AU - Kasai,Takatoshi, AU - Miyauchi,Katsumi, AU - Takasu,Kiyoshi, AU - Kajimoto,Kan, AU - Kubota,Naozumi, AU - Amano,Atsushi, AU - Daida,Hiroyuki, Y1 - 2012/10/12/ PY - 2012/05/08/received PY - 2012/07/21/revised PY - 2012/08/13/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/4/27/medline SP - 438 EP - 42 JF - Journal of cardiology JO - J Cardiol VL - 60 IS - 6 N2 - BACKGROUND: Chronic kidney disease (CKD) is closely associated with a higher risk of cardiovascular disease. However, whether patients with acute coronary syndrome (ACS) and CKD are at increased risk for long-term mortality after coronary revascularization remains unknown. METHODS AND RESULTS: Data from consecutive patients with ACS who had undergone coronary revascularization, including percutaneous coronary intervention (PCI) and coronary artery bypass surgery (CABG) were analyzed. The estimated glomerular filtration rate (eGFR) was calculated using the current Japanese equation and CKD was defined as eGFR < 60 mL/min/1.73 m(2). Among 375 enrolled patients with ACS, 75 (20.0%) had CKD. During a follow-up period of 10.0 ± 3.4 years, the total number of deaths was 80 (21.3%), of which 36 (9.6%) were due to cardiovascular causes. Kaplan-Meier analysis showed that the presence of CKD was associated with a significant increase in mortality from all causes (log-rank test, p<0.001) and cardiovascular mortality (p<0.001). Cox proportional-hazard analysis revealed that CKD increased the risk of mortality with a hazard ratio of 2.31 (95% confidence interval (CI): 1.25-4.29, p=0.008) and of cardiovascular death with a hazard ratio of 3.76 (95% CI: 1.60-8.80, p=0.002) in patients with ACS. CONCLUSIONS: CKD is a powerful determinant of long-term all-cause and cardiovascular mortality after ACS. SN - 1876-4738 UR - https://www.unboundmedicine.com/medline/citation/23063662/Prognostic_impact_of_chronic_kidney_disease_on_10_year_clinical_outcomes_among_patients_with_acute_coronary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0914-5087(12)00195-5 DB - PRIME DP - Unbound Medicine ER -