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Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats.
Eur J Pharmacol. 2012 Dec 15; 697(1-3):53-8.EJ

Abstract

Pyrroloquinoline quinone PQQ is a naturally occurring redox cofactor that acts as an essential nutrient, antioxidant, and redox modulator. PQQ has been demonstrated to oxidize the redox modulatory site of N-methyl-d-aspartic acid (NMDA) receptors. Such agents are known to be neuroprotective in experimental stroke models. However, there is not report about the therapeutic effect of PQQ on neuropathic pain. We tested the effects of oral administration of PQQ on neuropathic pain of rats with chronic constriction injury (CCI) of the sciatic nerve. The repeated oral administration of PQQ (20 and 40mg/kg, once a day for 4 weeks, from day 1 after the injury) attenuated both thermal and mechanical hyperalgesia, and also attenuated the muscle atrophy. The anti-hyperalgesic activity of PQQ was associated with a significant reduction of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-α) and lipid peroxide malondialdehyde (MDA) levels. In the present investigation, PQQ is shown to have analgesic effect which was found in the first time, probably through reducing the release of pro-inflammatory mediator and inhibiting oxidative stress.

Authors+Show Affiliations

China-Japanese Joint Institute for Medical and Pharmaceutical Science, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23063836

Citation

Gong, Dezheng, et al. "Effect of Pyrroloquinoline Quinone On Neuropathic Pain Following Chronic Constriction Injury of the Sciatic Nerve in Rats." European Journal of Pharmacology, vol. 697, no. 1-3, 2012, pp. 53-8.
Gong D, Geng C, Jiang L, et al. Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats. Eur J Pharmacol. 2012;697(1-3):53-8.
Gong, D., Geng, C., Jiang, L., Aoki, Y., Nakano, M., & Zhong, L. (2012). Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats. European Journal of Pharmacology, 697(1-3), 53-8. https://doi.org/10.1016/j.ejphar.2012.09.052
Gong D, et al. Effect of Pyrroloquinoline Quinone On Neuropathic Pain Following Chronic Constriction Injury of the Sciatic Nerve in Rats. Eur J Pharmacol. 2012 Dec 15;697(1-3):53-8. PubMed PMID: 23063836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats. AU - Gong,Dezheng, AU - Geng,Chengyan, AU - Jiang,Liping, AU - Aoki,Yoshinori, AU - Nakano,Masahiko, AU - Zhong,Laifu, Y1 - 2012/10/12/ PY - 2012/04/29/received PY - 2012/09/19/revised PY - 2012/09/22/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/5/3/medline SP - 53 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 697 IS - 1-3 N2 - Pyrroloquinoline quinone PQQ is a naturally occurring redox cofactor that acts as an essential nutrient, antioxidant, and redox modulator. PQQ has been demonstrated to oxidize the redox modulatory site of N-methyl-d-aspartic acid (NMDA) receptors. Such agents are known to be neuroprotective in experimental stroke models. However, there is not report about the therapeutic effect of PQQ on neuropathic pain. We tested the effects of oral administration of PQQ on neuropathic pain of rats with chronic constriction injury (CCI) of the sciatic nerve. The repeated oral administration of PQQ (20 and 40mg/kg, once a day for 4 weeks, from day 1 after the injury) attenuated both thermal and mechanical hyperalgesia, and also attenuated the muscle atrophy. The anti-hyperalgesic activity of PQQ was associated with a significant reduction of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-α) and lipid peroxide malondialdehyde (MDA) levels. In the present investigation, PQQ is shown to have analgesic effect which was found in the first time, probably through reducing the release of pro-inflammatory mediator and inhibiting oxidative stress. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/23063836/Effect_of_pyrroloquinoline_quinone_on_neuropathic_pain_following_chronic_constriction_injury_of_the_sciatic_nerve_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(12)00845-X DB - PRIME DP - Unbound Medicine ER -