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Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases.
Prostaglandins Other Lipid Mediat. 2012 Dec; 99(3-4):57-67.PO

Abstract

Chronic airway inflammation is a common symptom of several diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Excessive or inappropriate immune system activity and/or failure to resolve an acute inflammation spontaneously can induce functional changes in the walls and parenchyma of the airways. Continuous recruitment of inflammatory cells to the site of inflammation and the production of protein (i.e., cytokines, chemokines, enzymes, etc.) and lipid (eicosanoids) pro-inflammatory mediators contribute directly or indirectly to changes in airway structure and function. Pro-inflammatory eicosanoids are mainly formed by the metabolism of arachidonic acid, an n-6 polyunsaturated fatty acid esterified at the s-n2 position of membrane phospholipids. Unlike n-6 polyunsaturated fatty acids (PUFA), n-3 PUFA decrease inflammation. The anti-inflammatory effect of n-3 PUFA derives from their ability to compete with arachidonic acid in the production of eicosanoids, thereby decreasing the production of pro-inflammatory cytokines and reducing immune cell functions. Moreover, n-3 PUFA can give rise to a series of pro-resolving mediators with anti-inflammatory actions, such as resolvins and protectins. While most studies have reported n-3 PUFA to have beneficial effects on chronic airway diseases, some have questioned the anti-inflammatory effects of n-3 PUFA in inflammatory airway diseases. This paper summarizes the main mechanisms by which n-3 PUFA exert anti-inflammatory and pro-resolving effects, focusing on their use in airway disorders with an inflammatory component.

Authors+Show Affiliations

Laboratory of Biochemistry and Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy. anna.giudetti@unisalento.itNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23064030

Citation

Giudetti, Anna Maria, and Raffaele Cagnazzo. "Beneficial Effects of N-3 PUFA On Chronic Airway Inflammatory Diseases." Prostaglandins & Other Lipid Mediators, vol. 99, no. 3-4, 2012, pp. 57-67.
Giudetti AM, Cagnazzo R. Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. Prostaglandins Other Lipid Mediat. 2012;99(3-4):57-67.
Giudetti, A. M., & Cagnazzo, R. (2012). Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. Prostaglandins & Other Lipid Mediators, 99(3-4), 57-67. https://doi.org/10.1016/j.prostaglandins.2012.09.006
Giudetti AM, Cagnazzo R. Beneficial Effects of N-3 PUFA On Chronic Airway Inflammatory Diseases. Prostaglandins Other Lipid Mediat. 2012;99(3-4):57-67. PubMed PMID: 23064030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. AU - Giudetti,Anna Maria, AU - Cagnazzo,Raffaele, Y1 - 2012/10/11/ PY - 2012/01/03/received PY - 2012/09/26/revised PY - 2012/09/27/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/4/17/medline SP - 57 EP - 67 JF - Prostaglandins & other lipid mediators JO - Prostaglandins Other Lipid Mediat. VL - 99 IS - 3-4 N2 - Chronic airway inflammation is a common symptom of several diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Excessive or inappropriate immune system activity and/or failure to resolve an acute inflammation spontaneously can induce functional changes in the walls and parenchyma of the airways. Continuous recruitment of inflammatory cells to the site of inflammation and the production of protein (i.e., cytokines, chemokines, enzymes, etc.) and lipid (eicosanoids) pro-inflammatory mediators contribute directly or indirectly to changes in airway structure and function. Pro-inflammatory eicosanoids are mainly formed by the metabolism of arachidonic acid, an n-6 polyunsaturated fatty acid esterified at the s-n2 position of membrane phospholipids. Unlike n-6 polyunsaturated fatty acids (PUFA), n-3 PUFA decrease inflammation. The anti-inflammatory effect of n-3 PUFA derives from their ability to compete with arachidonic acid in the production of eicosanoids, thereby decreasing the production of pro-inflammatory cytokines and reducing immune cell functions. Moreover, n-3 PUFA can give rise to a series of pro-resolving mediators with anti-inflammatory actions, such as resolvins and protectins. While most studies have reported n-3 PUFA to have beneficial effects on chronic airway diseases, some have questioned the anti-inflammatory effects of n-3 PUFA in inflammatory airway diseases. This paper summarizes the main mechanisms by which n-3 PUFA exert anti-inflammatory and pro-resolving effects, focusing on their use in airway disorders with an inflammatory component. SN - 1098-8823 UR - https://www.unboundmedicine.com/medline/citation/23064030/Beneficial_effects_of_n_3_PUFA_on_chronic_airway_inflammatory_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1098-8823(12)00123-2 DB - PRIME DP - Unbound Medicine ER -