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Bone disease in pediatric chronic kidney disease.
Pediatr Nephrol. 2013 Apr; 28(4):569-76.PN

Abstract

Children with long-standing chronic kidney disease (CKD) display clinical symptoms of bone disease, including bony deformities and fractures, which contribute to long-standing disability. Abnormalities in skeletal mineralization occur in a substantial proportion of this population and may contribute to chronic morbidity. Underscoring the potential contribution of parameters other than bone turnover to bone disease in CKD, a new definition for renal osteodystrophy (ROD), emphasizing the assessment of three key histologic descriptors, i.e., bone turnover (T), mineralization (M), and volume (V) (TMV), has been recommended in the assessment of all patients with CKD. Although bone biopsy is the only available method for assessing all three recommended areas of bone histology, this invasive procedure is not routinely used in any clinical setting; thus, a true understanding of the prevalence of abnormal turnover, defective mineralization, and altered bone volume throughout the course of CKD is limited. Recent data, however, have shed light on the progression of renal ROD throughout the course of CKD, including its early stages, as well as on the alterations in cell biology that accompany ROD.

Authors+Show Affiliations

Department of Pediatrics, David Geffen School of Medicine at UCLA, A2-383 MDCC, 650 Charles Young Drive, Los Angeles, CA, 90095, USA. kwesseling@mednet.ucla.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23064662

Citation

Wesseling-Perry, Katherine. "Bone Disease in Pediatric Chronic Kidney Disease." Pediatric Nephrology (Berlin, Germany), vol. 28, no. 4, 2013, pp. 569-76.
Wesseling-Perry K. Bone disease in pediatric chronic kidney disease. Pediatr Nephrol. 2013;28(4):569-76.
Wesseling-Perry, K. (2013). Bone disease in pediatric chronic kidney disease. Pediatric Nephrology (Berlin, Germany), 28(4), 569-76. https://doi.org/10.1007/s00467-012-2324-4
Wesseling-Perry K. Bone Disease in Pediatric Chronic Kidney Disease. Pediatr Nephrol. 2013;28(4):569-76. PubMed PMID: 23064662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone disease in pediatric chronic kidney disease. A1 - Wesseling-Perry,Katherine, Y1 - 2012/10/14/ PY - 2012/06/19/received PY - 2012/08/26/accepted PY - 2012/08/13/revised PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/7/13/medline SP - 569 EP - 76 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 28 IS - 4 N2 - Children with long-standing chronic kidney disease (CKD) display clinical symptoms of bone disease, including bony deformities and fractures, which contribute to long-standing disability. Abnormalities in skeletal mineralization occur in a substantial proportion of this population and may contribute to chronic morbidity. Underscoring the potential contribution of parameters other than bone turnover to bone disease in CKD, a new definition for renal osteodystrophy (ROD), emphasizing the assessment of three key histologic descriptors, i.e., bone turnover (T), mineralization (M), and volume (V) (TMV), has been recommended in the assessment of all patients with CKD. Although bone biopsy is the only available method for assessing all three recommended areas of bone histology, this invasive procedure is not routinely used in any clinical setting; thus, a true understanding of the prevalence of abnormal turnover, defective mineralization, and altered bone volume throughout the course of CKD is limited. Recent data, however, have shed light on the progression of renal ROD throughout the course of CKD, including its early stages, as well as on the alterations in cell biology that accompany ROD. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/23064662/Bone_disease_in_pediatric_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s00467-012-2324-4 DB - PRIME DP - Unbound Medicine ER -