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Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection.
Int J Mol Med. 2012 Dec; 30(6):1376-86.IJ

Abstract

The aim of this study was to compare the effectiveness of transient prehypertensive treatment with losartan compared with amlodipine in spontaneously hypertensive rats (SHRs) on long-term blood pressure (BP), cardiac and renal protection. SHRs were prehypertensively treated with losartan, amlodipine or saline. Rats were followed up until 46 weeks of age. The left ventricular (LV) geometry and function were assessed by echocardiography. Angiotensin II (Ang II) and aldosterone (Aldo) were measured by radioimmunoassay. Ang II type 1 (AT1R) and type 2 (AT2R) receptor protein expression was determined by western blotting. The systolic blood pressure (SBP) in losartan-treated SHRs (SHR-Los) was persistently reduced until 46 weeks of age, but returned to untreated SHR levels in amlodipine-treated SHRs (SHR-Aml) from 30 weeks onwards. Compared to untreated SHRs, the albuminuria excretion in SHR-Los at week 46 was markedly decreased, the plasma, myocardium and renal tissue Ang II and Aldo levels in SHR-Los at week 46 were markedly decreased; AT1R and TGF-β1 protein expression was downregulated and AT2R protein was upregulated. Compared to untreated SHRs, the left ventricular mass index (LVMI) and collagen volume fraction (CVF) in SHR-Los were markedly decreased until week 46, and the left ventricular ejection fraction (LVEF) and cardiac brain natriuretic peptide mRNA expression were improved, whereas similar LVMI and elevated CVF were observed in SHR-Aml, and the LVEF decreased significantly below that of untreated SHRs at week 46, with cardiac BNP mRNA expression increasing slightly. Prehypertensive treatment with losartan was more effective than amlodipine on delaying long-term BP increase and ameliorating cardiac, renal structure and function, which may be related to the permanent attenuation of the circulating and local renin-angiotensin systems.

Authors+Show Affiliations

First Clinical Medical College of Fujian Medical University, Fuzhou 350005, P.R. China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23064712

Citation

Peng, Feng, et al. "Transient Prehypertensive Treatment in Spontaneously Hypertensive Rats: a Comparison of Losartan and Amlodipine Regarding Long-term Blood Pressure, Cardiac and Renal Protection." International Journal of Molecular Medicine, vol. 30, no. 6, 2012, pp. 1376-86.
Peng F, Lin J, Lin L, et al. Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection. Int J Mol Med. 2012;30(6):1376-86.
Peng, F., Lin, J., Lin, L., & Tang, H. (2012). Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection. International Journal of Molecular Medicine, 30(6), 1376-86. https://doi.org/10.3892/ijmm.2012.1153
Peng F, et al. Transient Prehypertensive Treatment in Spontaneously Hypertensive Rats: a Comparison of Losartan and Amlodipine Regarding Long-term Blood Pressure, Cardiac and Renal Protection. Int J Mol Med. 2012;30(6):1376-86. PubMed PMID: 23064712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection. AU - Peng,Feng, AU - Lin,Jinxiu, AU - Lin,Liming, AU - Tang,Hong, Y1 - 2012/10/09/ PY - 2012/07/07/received PY - 2012/08/21/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2013/5/29/medline SP - 1376 EP - 86 JF - International journal of molecular medicine JO - Int J Mol Med VL - 30 IS - 6 N2 - The aim of this study was to compare the effectiveness of transient prehypertensive treatment with losartan compared with amlodipine in spontaneously hypertensive rats (SHRs) on long-term blood pressure (BP), cardiac and renal protection. SHRs were prehypertensively treated with losartan, amlodipine or saline. Rats were followed up until 46 weeks of age. The left ventricular (LV) geometry and function were assessed by echocardiography. Angiotensin II (Ang II) and aldosterone (Aldo) were measured by radioimmunoassay. Ang II type 1 (AT1R) and type 2 (AT2R) receptor protein expression was determined by western blotting. The systolic blood pressure (SBP) in losartan-treated SHRs (SHR-Los) was persistently reduced until 46 weeks of age, but returned to untreated SHR levels in amlodipine-treated SHRs (SHR-Aml) from 30 weeks onwards. Compared to untreated SHRs, the albuminuria excretion in SHR-Los at week 46 was markedly decreased, the plasma, myocardium and renal tissue Ang II and Aldo levels in SHR-Los at week 46 were markedly decreased; AT1R and TGF-β1 protein expression was downregulated and AT2R protein was upregulated. Compared to untreated SHRs, the left ventricular mass index (LVMI) and collagen volume fraction (CVF) in SHR-Los were markedly decreased until week 46, and the left ventricular ejection fraction (LVEF) and cardiac brain natriuretic peptide mRNA expression were improved, whereas similar LVMI and elevated CVF were observed in SHR-Aml, and the LVEF decreased significantly below that of untreated SHRs at week 46, with cardiac BNP mRNA expression increasing slightly. Prehypertensive treatment with losartan was more effective than amlodipine on delaying long-term BP increase and ameliorating cardiac, renal structure and function, which may be related to the permanent attenuation of the circulating and local renin-angiotensin systems. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/23064712/Transient_prehypertensive_treatment_in_spontaneously_hypertensive_rats:_a_comparison_of_losartan_and_amlodipine_regarding_long_term_blood_pressure_cardiac_and_renal_protection_ L2 - http://www.spandidos-publications.com/ijmm/30/6/1376 DB - PRIME DP - Unbound Medicine ER -