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Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients.
Int Urol Nephrol. 2013 Jun; 45(3):879-84.IU

Abstract

OBJECTIVE

Associations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients.

METHODS

In nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol.

RESULTS

While mean 25(OH)D significantly increased from (10.2 ± 4.9 ng/ml) to (82.9 ± 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 ± 3.6) to (2.8 ± 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 ± 17.6 ng/ml) significantly increased (18.1 ± 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 ± 276.6 pg/ml to 434.0 ± 273.4 ng/ml.

CONCLUSIONS

Cholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance. The results of this study need to be confirmed in larger clinical trials.

Authors+Show Affiliations

Nephrology Department, Medical Faculty, Inonu University, Malatya, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23065434

Citation

Ulutas, Ozkan, et al. "Vitamin D Deficiency, Insulin Resistance, Serum Adipokine, and Leptin Levels in Peritoneal Dialysis Patients." International Urology and Nephrology, vol. 45, no. 3, 2013, pp. 879-84.
Ulutas O, Taskapan H, Taskapan MC, et al. Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients. Int Urol Nephrol. 2013;45(3):879-84.
Ulutas, O., Taskapan, H., Taskapan, M. C., & Temel, I. (2013). Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients. International Urology and Nephrology, 45(3), 879-84. https://doi.org/10.1007/s11255-012-0308-8
Ulutas O, et al. Vitamin D Deficiency, Insulin Resistance, Serum Adipokine, and Leptin Levels in Peritoneal Dialysis Patients. Int Urol Nephrol. 2013;45(3):879-84. PubMed PMID: 23065434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients. AU - Ulutas,Ozkan, AU - Taskapan,Hulya, AU - Taskapan,Mehmet Cagatay, AU - Temel,Ismail, Y1 - 2012/10/12/ PY - 2012/07/07/received PY - 2012/09/24/accepted PY - 2012/10/16/entrez PY - 2012/10/16/pubmed PY - 2014/3/5/medline SP - 879 EP - 84 JF - International urology and nephrology JO - Int Urol Nephrol VL - 45 IS - 3 N2 - OBJECTIVE: Associations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients. METHODS: In nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol. RESULTS: While mean 25(OH)D significantly increased from (10.2 ± 4.9 ng/ml) to (82.9 ± 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 ± 3.6) to (2.8 ± 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 ± 17.6 ng/ml) significantly increased (18.1 ± 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 ± 276.6 pg/ml to 434.0 ± 273.4 ng/ml. CONCLUSIONS: Cholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance. The results of this study need to be confirmed in larger clinical trials. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/23065434/Vitamin_D_deficiency_insulin_resistance_serum_adipokine_and_leptin_levels_in_peritoneal_dialysis_patients_ L2 - https://doi.org/10.1007/s11255-012-0308-8 DB - PRIME DP - Unbound Medicine ER -