Tags

Type your tag names separated by a space and hit enter

Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up.

Abstract

BACKGROUND

Gastric cancer is the second most common cause of death from cancer in the world. Epidemiological findings on alcohol use in relation to gastric cancer remain controversial. The aim of this study was to examine the effect of alcohol consumption on the risk of gastric cancer.

METHODS

The association between alcohol intake and the risk of gastric cancer was examined in a population-based cohort of 7,150 men in Kaunas, Lithuania, who were enrolled during 1972-1974 or 1976-1980. After up to 30 years of follow-up, 185 gastric cancer cases were identified. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). The attained age was used as a time-scale.

RESULTS

After adjustment for smoking, education level and body mass index, the HR of gastric cancer was 2.00 (95% CI: 1.04-3.82) for the highest alcohol consumption frequency (2-7 times per week) compared with occasional drinking (a few times per year) and 1.90 (95% CI: 1.13-3.18) for ≥ 100.0 g ethanol/week versus 0.1-9.9 g ethanol/week. A stronger effect of alcohol consumption on gastric cancer risk was observed during the second half of the study (1993-2008). In the analysis of gastric cancer risk by alcoholic beverage type, all beverages were included simultaneously in the model. The multivariate HR for men who consumed ≥ 0.5 litre of wine per occasion (compared with those who consumed <0.5 litre) was 2.95 (95% CI: 1.30-6.68). Higher consumption of beer or vodka was not statistically significantly associated with gastric cancer risk. After adjustment for smoking, education level, body mass index and ethanol, we found no excess risk of gastric cancer in association with total acetaldehyde intake.

CONCLUSIONS

This study supports a link between alcohol consumption (primarily from ethanol) and the development of gastric cancer in the Lithuanian population. Although an association with heavy wine consumption was observed, the effect of exposure to acetaldehyde on the development of gastric cancer in this cohort was not confirmed. Further research is needed to provide a more detailed evaluation of alcohol drinking and gastric cancer risk.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Group of Epidemiology, Institute of Oncology, Vilnius University, Baublio 3B, LT-08406 Vilnius, Lithuania. ruta.everatt@vuoi.lt

    , , , , ,

    Source

    BMC cancer 12: 2012 Oct 15 pg 475

    MeSH

    Acetaldehyde
    Aged
    Alcohol Drinking
    Alcoholic Beverages
    Body Mass Index
    Cohort Studies
    Confidence Intervals
    Educational Status
    Follow-Up Studies
    Humans
    Lithuania
    Male
    Proportional Hazards Models
    Risk
    Smoking
    Stomach Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23066954

    Citation

    Everatt, Ruta, et al. "Alcohol Consumption and Risk of Gastric Cancer: a Cohort Study of Men in Kaunas, Lithuania, With Up to 30 Years Follow-up." BMC Cancer, vol. 12, 2012, p. 475.
    Everatt R, Tamosiunas A, Kuzmickiene I, et al. Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up. BMC Cancer. 2012;12:475.
    Everatt, R., Tamosiunas, A., Kuzmickiene, I., Virviciute, D., Radisauskas, R., Reklaitiene, R., & Milinaviciene, E. (2012). Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up. BMC Cancer, 12, p. 475. doi:10.1186/1471-2407-12-475.
    Everatt R, et al. Alcohol Consumption and Risk of Gastric Cancer: a Cohort Study of Men in Kaunas, Lithuania, With Up to 30 Years Follow-up. BMC Cancer. 2012 Oct 15;12:475. PubMed PMID: 23066954.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up. AU - Everatt,Ruta, AU - Tamosiunas,Abdonas, AU - Kuzmickiene,Irena, AU - Virviciute,Dalia, AU - Radisauskas,Ricardas, AU - Reklaitiene,Regina, AU - Milinaviciene,Egle, Y1 - 2012/10/15/ PY - 2012/06/20/received PY - 2012/10/10/accepted PY - 2012/10/17/entrez PY - 2012/10/17/pubmed PY - 2013/8/24/medline SP - 475 EP - 475 JF - BMC cancer JO - BMC Cancer VL - 12 N2 - BACKGROUND: Gastric cancer is the second most common cause of death from cancer in the world. Epidemiological findings on alcohol use in relation to gastric cancer remain controversial. The aim of this study was to examine the effect of alcohol consumption on the risk of gastric cancer. METHODS: The association between alcohol intake and the risk of gastric cancer was examined in a population-based cohort of 7,150 men in Kaunas, Lithuania, who were enrolled during 1972-1974 or 1976-1980. After up to 30 years of follow-up, 185 gastric cancer cases were identified. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). The attained age was used as a time-scale. RESULTS: After adjustment for smoking, education level and body mass index, the HR of gastric cancer was 2.00 (95% CI: 1.04-3.82) for the highest alcohol consumption frequency (2-7 times per week) compared with occasional drinking (a few times per year) and 1.90 (95% CI: 1.13-3.18) for ≥ 100.0 g ethanol/week versus 0.1-9.9 g ethanol/week. A stronger effect of alcohol consumption on gastric cancer risk was observed during the second half of the study (1993-2008). In the analysis of gastric cancer risk by alcoholic beverage type, all beverages were included simultaneously in the model. The multivariate HR for men who consumed ≥ 0.5 litre of wine per occasion (compared with those who consumed <0.5 litre) was 2.95 (95% CI: 1.30-6.68). Higher consumption of beer or vodka was not statistically significantly associated with gastric cancer risk. After adjustment for smoking, education level, body mass index and ethanol, we found no excess risk of gastric cancer in association with total acetaldehyde intake. CONCLUSIONS: This study supports a link between alcohol consumption (primarily from ethanol) and the development of gastric cancer in the Lithuanian population. Although an association with heavy wine consumption was observed, the effect of exposure to acetaldehyde on the development of gastric cancer in this cohort was not confirmed. Further research is needed to provide a more detailed evaluation of alcohol drinking and gastric cancer risk. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/23066954/Alcohol_consumption_and_risk_of_gastric_cancer:_a_cohort_study_of_men_in_Kaunas_Lithuania_with_up_to_30_years_follow_up_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-475 DB - PRIME DP - Unbound Medicine ER -