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Discriminative stimulus effects of N,N-diisopropyltryptamine.
Psychopharmacology (Berl). 2013 Mar; 226(2):241-6.P

Abstract

RATIONALE

Serotonergic hallucinogens such as (+)-lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT) produce distinctive visual effects, whereas the synthetic hallucinogen N,N-diisopropyltryptamine (DiPT) is known for its production of auditory distortions.

OBJECTIVE

This study compares the discriminative stimulus effects of DiPT to those of visual hallucinogens.

METHODS

Adult male rats were trained to discriminate DiPT (5 mg/kg, 15 min) from saline under a FR10 schedule. A dose-effect and time course of DiPT's discriminative stimulus effects were established. DMT, (-)-2,5-dimethoxy-4-methylamphetamine (DOM), LSD, (±)-methylenedioxymethamphetamine (MDMA), and (+)-methamphetamine were tested for cross-substitution in DiPT-trained animals.

RESULTS

Rats learned to discriminate DiPT from saline in an average of 60 training sessions (30 drug and 30 saline). DiPT (0.5-5 mg/kg) produced dose-dependent increases in drug-appropriate responding (DAR) to 99 % (ED(50) = 2.47 mg/kg). Onset of the discriminative stimulus effects was within 5 min, and the effects dissipated within 4 h. Full substitution for the discriminative stimulus effects of DiPT occurred with LSD, DOM, and MDMA. DMT only partially substituted for DiPT (65 % DAR), whereas (+)-methamphetamine failed to substitute for DiPT (29 % DAR).

CONCLUSIONS

The discriminative stimulus effects of DiPT were similar those of a number of synthetic hallucinogens, only partially similar to those of DMT, but not similar to (+)-methamphetamine. The putative DiPT-induced auditory distortions do not lead to discriminative stimulus effects distinguishable from other hallucinogens.

Authors+Show Affiliations

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23070023

Citation

Carbonaro, Theresa M., et al. "Discriminative Stimulus Effects of N,N-diisopropyltryptamine." Psychopharmacology, vol. 226, no. 2, 2013, pp. 241-6.
Carbonaro TM, Forster MJ, Gatch MB. Discriminative stimulus effects of N,N-diisopropyltryptamine. Psychopharmacology (Berl). 2013;226(2):241-6.
Carbonaro, T. M., Forster, M. J., & Gatch, M. B. (2013). Discriminative stimulus effects of N,N-diisopropyltryptamine. Psychopharmacology, 226(2), 241-6. https://doi.org/10.1007/s00213-012-2891-x
Carbonaro TM, Forster MJ, Gatch MB. Discriminative Stimulus Effects of N,N-diisopropyltryptamine. Psychopharmacology (Berl). 2013;226(2):241-6. PubMed PMID: 23070023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus effects of N,N-diisopropyltryptamine. AU - Carbonaro,Theresa M, AU - Forster,Michael J, AU - Gatch,Michael B, Y1 - 2012/10/16/ PY - 2012/08/08/received PY - 2012/10/03/accepted PY - 2012/10/17/entrez PY - 2012/10/17/pubmed PY - 2013/9/11/medline SP - 241 EP - 6 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 226 IS - 2 N2 - RATIONALE: Serotonergic hallucinogens such as (+)-lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT) produce distinctive visual effects, whereas the synthetic hallucinogen N,N-diisopropyltryptamine (DiPT) is known for its production of auditory distortions. OBJECTIVE: This study compares the discriminative stimulus effects of DiPT to those of visual hallucinogens. METHODS: Adult male rats were trained to discriminate DiPT (5 mg/kg, 15 min) from saline under a FR10 schedule. A dose-effect and time course of DiPT's discriminative stimulus effects were established. DMT, (-)-2,5-dimethoxy-4-methylamphetamine (DOM), LSD, (±)-methylenedioxymethamphetamine (MDMA), and (+)-methamphetamine were tested for cross-substitution in DiPT-trained animals. RESULTS: Rats learned to discriminate DiPT from saline in an average of 60 training sessions (30 drug and 30 saline). DiPT (0.5-5 mg/kg) produced dose-dependent increases in drug-appropriate responding (DAR) to 99 % (ED(50) = 2.47 mg/kg). Onset of the discriminative stimulus effects was within 5 min, and the effects dissipated within 4 h. Full substitution for the discriminative stimulus effects of DiPT occurred with LSD, DOM, and MDMA. DMT only partially substituted for DiPT (65 % DAR), whereas (+)-methamphetamine failed to substitute for DiPT (29 % DAR). CONCLUSIONS: The discriminative stimulus effects of DiPT were similar those of a number of synthetic hallucinogens, only partially similar to those of DMT, but not similar to (+)-methamphetamine. The putative DiPT-induced auditory distortions do not lead to discriminative stimulus effects distinguishable from other hallucinogens. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/23070023/Discriminative_stimulus_effects_of_NN_diisopropyltryptamine_ L2 - https://dx.doi.org/10.1007/s00213-012-2891-x DB - PRIME DP - Unbound Medicine ER -