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[Add-on effect of dutasteride in patients with benign prostatic hyperplasia treated with alpha blocker : its effect on overactive bladder].
Hinyokika Kiyo. 2012 Sep; 58(9):475-80.HK

Abstract

We investigated the add-on effect of dutasteride (0.5 mg once a day) on lower urinary tract symptoms (LUTS), prostate volume (PV), and serum prostate specific antigen (PSA) and testosterone level in 72 patients with benign prostatic hyperplasia (BPH) who had been treated with alpha-blocker monotherapy. Inclusion criteria were men with BPH who had PV ≧30 ml and international prostate symptom score (IPSS) ≧8 or quality of life (QOL) index ≧3 under alpha-blocker monotherapy for more than 3 months. At the baseline, 12 and 24 weeks after dutasteride add-on, we assessed IPSS, overactive bladder symptom score (OABSS), PV, serum PSA and testosterone. Among 47 patients (65%) with OAB diagnosed by OABSS, responders were defined as those with urgency score of OABSS <2 or total score of OABSS <3. At the 24th week, dutasteride significantly improved IPSS (-4.2) and OABSS (-1.9) and reduced PV (-29%) compared with the baseline. Furthermore, dutasteride significantly decreased serum PSA (-45%) and increased testosterone (36%). Among OAB patients, dutasteride significantly improved urgency and urgency incontinence but not nocturia. Responders had lower OABSS, urgency incontinence score and serum testosterone at the baseline than non-responders. In conclusion, dutasteride add-on therapy is beneficial in patients with BPH who do not show enough improvement with alpha-blocker monotherapy.

Authors+Show Affiliations

The Department of Renal and Urologic Surgery, Asahikawa Medical University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

23070385

Citation

Wada, Naoki, et al. "[Add-on Effect of Dutasteride in Patients With Benign Prostatic Hyperplasia Treated With Alpha Blocker : Its Effect On Overactive Bladder]." Hinyokika Kiyo. Acta Urologica Japonica, vol. 58, no. 9, 2012, pp. 475-80.
Wada N, Hashidume K, Tamaki G, et al. [Add-on effect of dutasteride in patients with benign prostatic hyperplasia treated with alpha blocker : its effect on overactive bladder]. Hinyokika Kiyo. 2012;58(9):475-80.
Wada, N., Hashidume, K., Tamaki, G., Kita, M., Iwata, T., Matsumoto, S., & Kakizaki, H. (2012). [Add-on effect of dutasteride in patients with benign prostatic hyperplasia treated with alpha blocker : its effect on overactive bladder]. Hinyokika Kiyo. Acta Urologica Japonica, 58(9), 475-80.
Wada N, et al. [Add-on Effect of Dutasteride in Patients With Benign Prostatic Hyperplasia Treated With Alpha Blocker : Its Effect On Overactive Bladder]. Hinyokika Kiyo. 2012;58(9):475-80. PubMed PMID: 23070385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Add-on effect of dutasteride in patients with benign prostatic hyperplasia treated with alpha blocker : its effect on overactive bladder]. AU - Wada,Naoki, AU - Hashidume,Kazumi, AU - Tamaki,Gaku, AU - Kita,Masafumi, AU - Iwata,Tatsuya, AU - Matsumoto,Seiji, AU - Kakizaki,Hidehiro, PY - 2012/10/17/entrez PY - 2012/10/17/pubmed PY - 2012/12/21/medline SP - 475 EP - 80 JF - Hinyokika kiyo. Acta urologica Japonica JO - Hinyokika Kiyo VL - 58 IS - 9 N2 - We investigated the add-on effect of dutasteride (0.5 mg once a day) on lower urinary tract symptoms (LUTS), prostate volume (PV), and serum prostate specific antigen (PSA) and testosterone level in 72 patients with benign prostatic hyperplasia (BPH) who had been treated with alpha-blocker monotherapy. Inclusion criteria were men with BPH who had PV ≧30 ml and international prostate symptom score (IPSS) ≧8 or quality of life (QOL) index ≧3 under alpha-blocker monotherapy for more than 3 months. At the baseline, 12 and 24 weeks after dutasteride add-on, we assessed IPSS, overactive bladder symptom score (OABSS), PV, serum PSA and testosterone. Among 47 patients (65%) with OAB diagnosed by OABSS, responders were defined as those with urgency score of OABSS <2 or total score of OABSS <3. At the 24th week, dutasteride significantly improved IPSS (-4.2) and OABSS (-1.9) and reduced PV (-29%) compared with the baseline. Furthermore, dutasteride significantly decreased serum PSA (-45%) and increased testosterone (36%). Among OAB patients, dutasteride significantly improved urgency and urgency incontinence but not nocturia. Responders had lower OABSS, urgency incontinence score and serum testosterone at the baseline than non-responders. In conclusion, dutasteride add-on therapy is beneficial in patients with BPH who do not show enough improvement with alpha-blocker monotherapy. SN - 0018-1994 UR - https://www.unboundmedicine.com/medline/citation/23070385/[Add_on_effect_of_dutasteride_in_patients_with_benign_prostatic_hyperplasia_treated_with_alpha_blocker_:_its_effect_on_overactive_bladder]_ L2 - https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/160121 DB - PRIME DP - Unbound Medicine ER -