Prime

Type your tag names separated by a space and hit enter

Meta-analysis of early nonmotor features and risk factors for Parkinson disease.

Abstract

OBJECTIVE

To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening.

METHODS

A systematic review and meta-analysis of risk factors for PD.

RESULTS

The strongest associations with later diagnosis of PD were found for having a first-degree or any relative with PD (odds ratio [OR], 3.23; 95% confidence interval [CI], 2.65-3.93 and OR, 4.45; 95% CI, 3.39-5.83) or any relative with tremor (OR, 2.74; 95% CI, 2.10-3.57), constipation (relative risk [RR], 2.34; 95% CI, 1.55-3.53), or lack of smoking history (current vs never: RR, 0.44; 95% CI, 0.39-0.50), each at least doubling the risk of PD. Further positive significant associations were found for history of anxiety or depression, pesticide exposure, head injury, rural living, beta-blockers, farming occupation, and well-water drinking, and negative significant associations were found for coffee drinking, hypertension, nonsteroidal anti-inflammatory drugs, calcium channel blockers, and alcohol, but not for diabetes mellitus, cancer, oral contraceptive pill use, surgical menopause, hormone replacement therapy, statins, acetaminophen/paracetamol, aspirin, tea drinking, history of general anesthesia, or gastric ulcers. In the systematic review, additional associations included negative associations with raised serum urate, and single studies or studies with conflicting results.

INTERPRETATION

The strongest risk factors associated with later PD diagnosis are having a family history of PD or tremor, a history of constipation, and lack of smoking history. Further factors also but less strongly contribute to risk of PD diagnosis or, as some premotor symptoms, require further standardized studies to demonstrate the magnitude of risk associated with them.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Neurology, University College London, London, United Kingdom.

    , , , , ,

    Source

    Annals of neurology 72:6 2012 Dec pg 893-901

    MeSH

    Alcohol Drinking
    Anti-Inflammatory Agents, Non-Steroidal
    Coffee
    Confidence Intervals
    Family Health
    Female
    Humans
    MEDLINE
    Male
    Odds Ratio
    Parkinson Disease
    Risk Factors
    Smoking
    Tremor

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    23071076

    Citation

    TY - JOUR T1 - Meta-analysis of early nonmotor features and risk factors for Parkinson disease. AU - Noyce,Alastair J, AU - Bestwick,Jonathan P, AU - Silveira-Moriyama,Laura, AU - Hawkes,Christopher H, AU - Giovannoni,Gavin, AU - Lees,Andrew J, AU - Schrag,Anette, Y1 - 2012/10/15/ PY - 2012/5/11/received PY - 2012/6/19/revised PY - 2012/7/6/accepted PY - 2012/10/15/aheadofprint PY - 2012/10/17/entrez PY - 2012/10/17/pubmed PY - 2013/2/26/medline SP - 893 EP - 901 JF - Annals of neurology JO - Ann. Neurol. VL - 72 IS - 6 N2 - OBJECTIVE: To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening. METHODS: A systematic review and meta-analysis of risk factors for PD. RESULTS: The strongest associations with later diagnosis of PD were found for having a first-degree or any relative with PD (odds ratio [OR], 3.23; 95% confidence interval [CI], 2.65-3.93 and OR, 4.45; 95% CI, 3.39-5.83) or any relative with tremor (OR, 2.74; 95% CI, 2.10-3.57), constipation (relative risk [RR], 2.34; 95% CI, 1.55-3.53), or lack of smoking history (current vs never: RR, 0.44; 95% CI, 0.39-0.50), each at least doubling the risk of PD. Further positive significant associations were found for history of anxiety or depression, pesticide exposure, head injury, rural living, beta-blockers, farming occupation, and well-water drinking, and negative significant associations were found for coffee drinking, hypertension, nonsteroidal anti-inflammatory drugs, calcium channel blockers, and alcohol, but not for diabetes mellitus, cancer, oral contraceptive pill use, surgical menopause, hormone replacement therapy, statins, acetaminophen/paracetamol, aspirin, tea drinking, history of general anesthesia, or gastric ulcers. In the systematic review, additional associations included negative associations with raised serum urate, and single studies or studies with conflicting results. INTERPRETATION: The strongest risk factors associated with later PD diagnosis are having a family history of PD or tremor, a history of constipation, and lack of smoking history. Further factors also but less strongly contribute to risk of PD diagnosis or, as some premotor symptoms, require further standardized studies to demonstrate the magnitude of risk associated with them. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/23071076/full_citation L2 - http://dx.doi.org/10.1002/ana.23687 ER -