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Effects of changes in adiposity and physical activity on preadolescent insulin resistance: the Australian LOOK longitudinal study.
PLoS One. 2012; 7(10):e47438.Plos

Abstract

BACKGROUND

In a previous longitudinal analysis of our cohort as 8 to 10 year-olds, insulin resistance (IR) increased with age, but was not modified by changes in percent body fat (%BF), and was only responsive to changes in physical activity (PA) in boys. We aimed to determine whether these responses persisted as the children approached adolescence.

METHODS

In this prospective cohort study, 256 boys and 278 girls were assessed at ages 8, 10 and 12 years for fasting blood glucose and insulin, %BF (dual energy X-ray absorptiometry); PA (7-day pedometers), fitness (multistage run); and pubertal development (Tanner stage).

RESULTS

From age 8 to 12 years, the median homeostatic model of IR (HOMA-IR) doubled in boys and increased 250% in girls. By age 12, 23% of boys and 31% of girls had elevated IR, as indicated by HOMA-IR greater than 3. Longitudinal relationships, with important adjustments for covariates body weight, PA, %BF, Tanner score and socioeconomic status showed that, on average, for every 1 unit reduction of %BF, HOMA-IR was lowered by 2.2% (95% CI 0.04-4) in girls and 1.6% (95% CI 0-3.2) in boys. Furthermore, in boys but not girls, HOMA-IR was decreased by 3.5% (95%CI 0.5-6.5) if PA was increased by 2100 steps/day.

CONCLUSION

Evidence that a quarter of our apparently healthy 12 year-old Australians possessed elevated IR suggests that community-based education and prevention strategies may be warranted. Responsiveness of IR to changes in %BF in both sexes during late preadolescence and to changes in PA in the boys provides a specific basis for targeting elevated IR. That body weight was a strong covariate of IR, independent of %BF, points to the importance of adjusting for weight in correctly assessing these relationships in growing children.

Authors+Show Affiliations

College of Medicine, Biology and Environment, Australian National University, Canberra, Australia. rtelford@cominst.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23071806

Citation

Telford, Richard D., et al. "Effects of Changes in Adiposity and Physical Activity On Preadolescent Insulin Resistance: the Australian LOOK Longitudinal Study." PloS One, vol. 7, no. 10, 2012, pp. e47438.
Telford RD, Cunningham RB, Telford RM, et al. Effects of changes in adiposity and physical activity on preadolescent insulin resistance: the Australian LOOK longitudinal study. PLoS One. 2012;7(10):e47438.
Telford, R. D., Cunningham, R. B., Telford, R. M., Kerrigan, J., Hickman, P. E., Potter, J. M., & Abhayaratna, W. P. (2012). Effects of changes in adiposity and physical activity on preadolescent insulin resistance: the Australian LOOK longitudinal study. PloS One, 7(10), e47438. https://doi.org/10.1371/journal.pone.0047438
Telford RD, et al. Effects of Changes in Adiposity and Physical Activity On Preadolescent Insulin Resistance: the Australian LOOK Longitudinal Study. PLoS One. 2012;7(10):e47438. PubMed PMID: 23071806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of changes in adiposity and physical activity on preadolescent insulin resistance: the Australian LOOK longitudinal study. AU - Telford,Richard D, AU - Cunningham,Ross B, AU - Telford,Rohan M, AU - Kerrigan,Jennifer, AU - Hickman,Peter E, AU - Potter,Julia M, AU - Abhayaratna,Walter P, Y1 - 2012/10/12/ PY - 2012/06/18/received PY - 2012/09/17/accepted PY - 2012/10/17/entrez PY - 2012/10/17/pubmed PY - 2013/2/23/medline SP - e47438 EP - e47438 JF - PloS one JO - PLoS One VL - 7 IS - 10 N2 - BACKGROUND: In a previous longitudinal analysis of our cohort as 8 to 10 year-olds, insulin resistance (IR) increased with age, but was not modified by changes in percent body fat (%BF), and was only responsive to changes in physical activity (PA) in boys. We aimed to determine whether these responses persisted as the children approached adolescence. METHODS: In this prospective cohort study, 256 boys and 278 girls were assessed at ages 8, 10 and 12 years for fasting blood glucose and insulin, %BF (dual energy X-ray absorptiometry); PA (7-day pedometers), fitness (multistage run); and pubertal development (Tanner stage). RESULTS: From age 8 to 12 years, the median homeostatic model of IR (HOMA-IR) doubled in boys and increased 250% in girls. By age 12, 23% of boys and 31% of girls had elevated IR, as indicated by HOMA-IR greater than 3. Longitudinal relationships, with important adjustments for covariates body weight, PA, %BF, Tanner score and socioeconomic status showed that, on average, for every 1 unit reduction of %BF, HOMA-IR was lowered by 2.2% (95% CI 0.04-4) in girls and 1.6% (95% CI 0-3.2) in boys. Furthermore, in boys but not girls, HOMA-IR was decreased by 3.5% (95%CI 0.5-6.5) if PA was increased by 2100 steps/day. CONCLUSION: Evidence that a quarter of our apparently healthy 12 year-old Australians possessed elevated IR suggests that community-based education and prevention strategies may be warranted. Responsiveness of IR to changes in %BF in both sexes during late preadolescence and to changes in PA in the boys provides a specific basis for targeting elevated IR. That body weight was a strong covariate of IR, independent of %BF, points to the importance of adjusting for weight in correctly assessing these relationships in growing children. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23071806/Effects_of_changes_in_adiposity_and_physical_activity_on_preadolescent_insulin_resistance:_the_Australian_LOOK_longitudinal_study_ L2 - https://dx.plos.org/10.1371/journal.pone.0047438 DB - PRIME DP - Unbound Medicine ER -