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Human germline genetic modification: scientific and bioethical perspectives.
Arch Med Res 2012; 43(7):491-513AM

Abstract

The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering technology suggest that human germline genetic modification (HGGM) will become a safe and effective prospect in the relatively near future. Several substantive ethical objections have been raised against HGGM including claims of unacceptably high levels of risk, damage to the status of future persons, and violations of justice and autonomy. This paper critically reviews the latest GM science and discusses the key ethical objections to HGGM. We conclude that major benefits are likely to accrue through the use of safe and effective HGGM and that it would thus be unethical to take a precautionary stance against HGGM.

Authors+Show Affiliations

School of Contemporary Sciences, Abertay University, Dundee, United Kingdom. k.smith@tay.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23072719

Citation

Smith, Kevin R., et al. "Human Germline Genetic Modification: Scientific and Bioethical Perspectives." Archives of Medical Research, vol. 43, no. 7, 2012, pp. 491-513.
Smith KR, Chan S, Harris J. Human germline genetic modification: scientific and bioethical perspectives. Arch Med Res. 2012;43(7):491-513.
Smith, K. R., Chan, S., & Harris, J. (2012). Human germline genetic modification: scientific and bioethical perspectives. Archives of Medical Research, 43(7), pp. 491-513. doi:10.1016/j.arcmed.2012.09.003.
Smith KR, Chan S, Harris J. Human Germline Genetic Modification: Scientific and Bioethical Perspectives. Arch Med Res. 2012;43(7):491-513. PubMed PMID: 23072719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human germline genetic modification: scientific and bioethical perspectives. AU - Smith,Kevin R, AU - Chan,Sarah, AU - Harris,John, Y1 - 2012/10/13/ PY - 2012/03/16/received PY - 2012/09/06/accepted PY - 2012/10/18/entrez PY - 2012/10/18/pubmed PY - 2013/6/5/medline SP - 491 EP - 513 JF - Archives of medical research JO - Arch. Med. Res. VL - 43 IS - 7 N2 - The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering technology suggest that human germline genetic modification (HGGM) will become a safe and effective prospect in the relatively near future. Several substantive ethical objections have been raised against HGGM including claims of unacceptably high levels of risk, damage to the status of future persons, and violations of justice and autonomy. This paper critically reviews the latest GM science and discusses the key ethical objections to HGGM. We conclude that major benefits are likely to accrue through the use of safe and effective HGGM and that it would thus be unethical to take a precautionary stance against HGGM. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/23072719/Human_germline_genetic_modification:_scientific_and_bioethical_perspectives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(12)00244-5 DB - PRIME DP - Unbound Medicine ER -